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image of The Potential of Iranian Medicinal Plants in Combating Candida Albicans, A Major Cause of Oral Candidiasis: A Systematic Review

Abstract

Introduction

The weaknesses of traditional drugs against fungi, such as resistance and adverse reactions highlight the urgent need for alternative therapies. Plant extracts offer great potential for developing alternative antifungal therapies against . The current systematic study aimed to introduce medicinal plants native to Iran that could effectively combat , the primary cause of oral candidiasis.

Method

In this systematic review study, a search was performed for articles published in English from 2000 onwards in databases including PubMed, Google Scholar, ScienceDirect, Web of Sciences, and Scopus with keywords (“Herbal medicines” or “Extract” or “Essential oil” or ” Iran” or “Plant”) and “”, “”, and “Clinical trials,” considering the inclusion and exclusion criteria.

Results

From 170 studies initially retrieved from ScienceDirect, PubMed, Scopus, Ovid, and Cochrane databases, 124 duplicates were removed, and after this, 75 studies were transferred to EndNote software.

Discussion

Using the inclusion and exclusion criteria, 49 irrelevant studies were eliminated during the screening step once each study's title and abstract were assessed. Based on the availability of their full texts, the 45 remaining studies were evaluated. Finally, 37 studies were selected.

Conclusions

The study examined the impact of native plants from Iran on , a common cause of oral candidiasis, and suggests that by conducting more extensive research in the future, these plants could be used to develop new compounds for the treatment of oral candidiasis.

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2025-09-16
2025-12-24

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The Potential of Iranian Medicinal Plants in Combating Candida Albicans, A Major Cause of Oral Candidiasis: A Systematic Review
Bentham Science Publishers ; https://doi.org/10.2174/0122127968379046250903225716
/content/journals/ccb/10.2174/0122127968379046250903225716
/content/journals/ccb/10.2174/0122127968379046250903225716
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  • Article Type:     Review Article
Keywords: systematic review ; Candida albicans ; Medicinal plants ; oral candidiasis ; native of Iran

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