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2000
Volume 10, Issue 3
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Since the time of Ehrlich (1854-1915) the antimicrobial activity of synthetic, non-chemotherapeutic compounds like phenothiazines and methylene blue, has been known. This article reports synthesis of some new 10Hphenothiazines, their sulfones and nucleosides, which have shown antimicrobial activity to a good extent against some selected strains of fungi, Gram positive and Gram negative bacteria leading us to a possibly potent class of antimicrobial agents. Reported 10H-phenothiazines were prepared using smiles rearrangement. These synthesized 10H-phenothiazines yield sulfones on oxidation with 30% hydrogen peroxide in glacial acetic acid and form nucleosides when treated with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate (sugar). Structural assignment is done by spectral and elemental investigations.

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/content/journals/cbc/10.2174/1573407210666140728174315
2014-08-01
2025-08-18
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  • Article Type:
    Research Article
Keyword(s): 10H-phenothiazines; Antimicrobial activity; nucleosides; smiles rearrangement; sulfones
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