Skip to content
2000
Volume 22, Issue 3
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

This extensive review paper explores the ethnopharmacological viewpoints of L., commonly referred to as “Frangipani”, clarifying its complex phytochemistry and range of pharmacological characteristics. has a long history of ethnobotanical uses and is widely used in traditional medicinal practices across many countries. Through a methodical investigation of its phytochemical components, the review reveals a diverse range of bioactive substances, such as phenolic compounds, alkaloids, flavonoids, and terpenoids. The plant's potential for medicinal use is greatly enhanced by these ingredients. There is a thorough discussion of pharmacological characteristics, including its anti-inflammatory, antibacterial, antioxidant, and anticancer effects. Using information gathered from both current and historic studies, the article offers a comprehensive overview of the plant's many therapeutic uses. It also provides insights into the significance of using scientific research to validate traditional applications, opening the door for incorporation into contemporary healthcare procedures. This paper focuses on ethnomedical usage, describing its traditional use in the treatment of a range of ailments. The study points out information gaps and suggests future studies to explore its therapeutic and multi-mechanistic approaches. It also suggests possible directions for clinical investigations. To sum up, this study provides a comprehensive overview of L. by combining ethnopharmacological ideas, phytochemical data, and pharmacological discoveries. This plant presents itself as a good option for new medicinal uses when conventional wisdom and scientific investigation are combined.

Loading

Article metrics loading...

/content/journals/cbc/10.2174/0115734072350755250219104056
2025-02-27
2026-03-08
Loading full text...

Full text loading...

References

  1. MahajanN. RawalS. VermaM. PoddarM. AlokS. A phytopharmacological overview on Ocimum species with special emphasis on Ocimum sanctum.Biomed. Prev. Nutr.20133218519210.1016/j.bionut.2012.08.002
    [Google Scholar]
  2. PayyappallimanaU. VenkatasubramanianP. Exploring ayurvedic knowledge on food and health for providing innovative solutions to contemporary healthcare.Front. Public Health201645710.3389/fpubh.2016.00057 27066472
    [Google Scholar]
  3. MayoJ.L. Black cohosh and chasteberry: Herbs valued by women for centuries. Clin. Nutr. Insights,1998156
    [Google Scholar]
  4. JoshiP. DhawanV. Swertia chirayita - An overview.Curr. Sci.2005
    [Google Scholar]
  5. GholaisN.S. ShiC. ZhangJ. LiaoB. AlbarmaqiR.A. TangX. MiL. Network pharmacology-based investigation on the mechanism of the jinguanlan formula in treating acne vulgaris.Evid. Based Complement. Alternat. Med.2022202211310.1155/2022/6944792 35873639
    [Google Scholar]
  6. KankanamalageT.N.M. DharmadasaR.M. AbeysingheD.C. WijesekaraR.G.S. A survey on medicinal materials used in traditional systems of medicine in Sri Lanka.J. Ethnopharmacol.2014155167969110.1016/j.jep.2014.06.016 24933220
    [Google Scholar]
  7. DamanhouriZ.A. A review on therapeutic potential of Piper nigrum L. (Black pepper): The king of spices.Med. Aromat. Plants2014331610.4172/2167‑0412.1000161
    [Google Scholar]
  8. Gaurav; Khan, M.U.; Basist, P.; Zahiruddin, S.; Ibrahim, M.; Parveen, R.; Krishnan, A.; Ahmad, S. Nephroprotective potential of Boerhaavia diffusa and Tinospora cordifolia herbal combination against diclofenac induced nephrotoxicity.S. Afr. J. Bot.202215123824710.1016/j.sajb.2022.01.038
    [Google Scholar]
  9. GauravI. SharmaI. KhanM.U. ZahiruddinS. BasistP. AhmadS. Multi-mechanistic and therapeutic exploration of nephroprotective effect of traditional ayurvedic polyherbal formulation using in silico, in vitro and in vivo approaches.Biomedicines202311116810.3390/biomedicines11010168 36672676
    [Google Scholar]
  10. GautamG. Network pharmacology-based validation of traditional therapeutic claim of momordica charantiain alleviating diabetic nephropathy.J. CAM Res. Prog.20221111010.33790/jcrp1100102
    [Google Scholar]
  11. Gaurav; Khan, M.U.; Basist, P.; Zahiruddin S.; Ibrahim, M.; Praveen R.; Krishnan, A.; Ahmad, S. GC-MS metabolomics and network pharmacology-based investigation of molecular mechanism of identified metabolites from Tinospora cordifolia (Willd.) miers for the treatment of kidney diseases.Pharmacogn. Mag.2022187954855810.4103/pm.pm_582_21
    [Google Scholar]
  12. ChenD.Q. HuH.H. WangY.N. FengY.L. CaoG. ZhaoY.Y. Natural products for the prevention and treatment of kidney disease.Phytomedicine201850506010.1016/j.phymed.2018.09.182 30466992
    [Google Scholar]
  13. ScartezziniP. AntognoniF. RaggiM.A. PoliF. SabbioniC. Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn.J. Ethnopharmacol.20061041-211311810.1016/j.jep.2005.08.065 16226416
    [Google Scholar]
  14. HeY. LiZ. WangW. SoorannaS.R. ShiY. ChenY. WuC. ZengJ. TangQ. XieH. Chemical profiles and simultaneous quantification of Aurantii fructus by use of HPLC-Q-TOF-MS combined with GC-MS and HPLC methods.Molecules2018239218910.3390/molecules23092189 30200226
    [Google Scholar]
  15. IlangoK. Current status of Indian medicinal plants with immunomodulatory potential - A review. Vedic Res. Int. Phytomedicine,201310.14259/pm.v1i2.39
    [Google Scholar]
  16. BihaniT. TandelP. WadekarJ. Plumeria obtusa L.: A systematic review of its traditional uses, morphology, phytochemistry and pharmacology.Phytomed. Plus20211210005210.1016/j.phyplu.2021.100052
    [Google Scholar]
  17. NazS. ImranI. FarooqM.A. ShahS.A.H. AjmalI. ZahraZ. AslamA. SarwarM.I. ShahJ. AleemA. Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats.Front. Pharmacol.202213107757010.3389/fphar.2022.1077570 36588726
    [Google Scholar]
  18. EloutifyY.T. El-ShiekhR.A. IbrahimK.M. HamedA.R. Al-KarmalawyA.A. ShokryA.A. AhmedY.H. AvulaB. KatraguntaK. KhanI.A. MeselhyM.R. Bioactive fraction from Plumeria obtusa L. attenuates LPS-induced acute lung injury in mice and inflammation in RAW 264.7 macrophages: LC/QToF-MS and molecular docking.Inflammopharmacology202331285987510.1007/s10787‑023‑01144‑w 36773191
    [Google Scholar]
  19. KamariahA.S. LimL.B.L. BaserK.H.C. OzekT. DemirciB. Composition of the essential oil of Plumeria obtusa L.In: Flavour Fragr. J.,199914423724010.1002/(SICI)1099‑1026(199907/08)14:4237::AID‑FFJ817>3.0.CO;2‑Y
    [Google Scholar]
  20. PitpiangchanP. DilokkunanantU. SukkattaU. VajrodayaS. HaruethaitanasanV. PunjeeP. RukthawornP. Comparative Study of Scented Compound Extraction from Plumeria obtusa L.Kasetsart J. Nat. Sci.200943189196
    [Google Scholar]
  21. Plumeria obtusa, CABI Compendium; CABI International,202210.1079/cabicompendium.42058
    [Google Scholar]
  22. SaleemM. AkhtarN. RiazN. AliM.S. JabbarA. Isolation and characterization of secondary metabolites from Plumeria obtusa.J. Asian Nat. Prod. Res.201113121122112710.1080/10286020.2011.618452 22115036
    [Google Scholar]
  23. ShewaleS. UndaleV. BhalchimV. DesaiS. ShelarM. PadoleS. ChitlangeS. WawaleV. ParekhS. PujariP. Evaluation and assessment of the acute toxic potential of Sansevieria cylindrica and Plumeria obtusa plant extracts in Wistar albino rats.J. Nat. Rem.202222220910.18311/jnr/2022/28768
    [Google Scholar]
  24. BihaniT. MhaskeN. Evaluation of in vivo wound healing activity of Plumeria obtusa L. (Champa) spray in rats.Wound Med.20202810017610.1016/j.wndm.2019.100176
    [Google Scholar]
  25. KamranR.M. KhaliqH.A. UzairM. Pharmacognostic and phytochemical studies on Plumeria obtusa L. J.Phytopharm.20209212012410.31254/phyto.2020.9208
    [Google Scholar]
  26. SalarS. SharmaP. LambaH.S. SharmaJ. KaurA. Exploration of antioxidant activity of Plumeria obtusa L.Ann. Phytomed.202211253253910.54085/ap.2022.11.2.65
    [Google Scholar]
  27. GuptaS. Protective effect of Plumeria obtusa leaves extracts on dexamethasone-induced insulin-resistance diabetes mellitus in rats.Indian J. Pharm. Educ. Res.20225610.5530/ijper.55.1s.49
    [Google Scholar]
  28. DograN. Phytochemical analysis and in vitro antioxidant studies of Plumeria obtusa L. Leaves.Indian J. Pharm. Sci.201678116917110.4103/0250‑474X.180256 27168698
    [Google Scholar]
  29. PerveenS. NadeemR. RehmanS. AfzalN. AnjumS. NoreenS. SaeedR. AmamiM. Al-MijalliS.H. IqbalM. Green synthesis of iron (Fe) nanoparticles using Plumeria obtusa extract as a reducing and stabilizing agent: Antimicrobial, antioxidant and biocompatibility studies.Arab. J. Chem.202215510376410.1016/j.arabjc.2022.103764
    [Google Scholar]
  30. AliF.I. HashmiI.A. SiddiquiB.S. A novel iridoid from Plumeria obtusa.Nat. Prod. Commun.,2008321934578X080030020310.1177/1934578X0800300203
    [Google Scholar]
  31. SiddiquiB.S. IlyasF. RasheedM. BegumS. Chemical constituents of leaves and stem bark of Plumeria obtusa.Phytochemistry200465142077208410.1016/j.phytochem.2004.04.024 15279975
    [Google Scholar]
  32. Gaurav; Zahiruddin, S.; Parveen, B.; Ibrahim, M.; Sharma, I.; Sharma, S.; Sharma, A.K.; Parveen, R.; Ahmad, S. TLC-MS bioautography-based identification of free-radical scavenging, α-amylase, and α-glucosidase inhibitor compounds of antidiabetic tablet BGR-34.ACS Omega2020546296882969710.1021/acsomega.0c02995 33251404
    [Google Scholar]
  33. NarwariyaP. Comprehensive overview of Plumeria obtusa.World J. Pharm. Res.20176466467610.20959/wjpr20174‑8212
    [Google Scholar]
  34. El-SherbeniS.A. NegmW.A. The wound healing effect of botanicals and pure natural substances used in in vivo models.Inflammopharmacology202331275577210.1007/s10787‑023‑01157‑5 36811778
    [Google Scholar]
  35. SiddiquiS. SiddiquiB.S. NaeedA. BegumS. Pentacyclic triterpenoids from the leaves of Plumeria obtusa.Phytochemistry198928113143314710.1016/0031‑9422(89)80295‑X
    [Google Scholar]
  36. EloutifyY.T. El-ShiekhR.A. IbrahimK.M. ElshimyR. AvulaB. KatraguntaK. KhanI.A. MeselhyM.R. Bioassay-guided isolation of antimicrobial components and LC/QToF profile of Plumeria obtusa: Potential for the treatment of antimicrobial resistance.ACS Omega2023876476649110.1021/acsomega.2c06803 36844537
    [Google Scholar]
  37. BoonclarmD. SornwatanaT. ArthanD. KongsaereeP. SvastiJ. β-glucosidase catalyzing specific hydrolysis of an iridoid β-glucoside from Plumeria obtusa.Acta Biochim. Biophys. Sin.200638856357010.1111/j.1745‑7270.2006.00196.x 16894479
    [Google Scholar]
  38. SiddiquiS. SiddiquiB.S. BegumS. NaeedA. Pentacyclic triterpenoids from Plumeria obtusa.Phytochemistry199029113615362010.1016/0031‑9422(90)85287‑P
    [Google Scholar]
  39. SemenyaS. PotgieterM. ErasmusL. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa.J. Ethnopharmacol.2012141144044510.1016/j.jep.2012.03.008 22430018
    [Google Scholar]
  40. BhuvaneswariS. AravindK.R. RamkumarB. RajaN.V. NeelakandanA. KumarP.M. PrakashN.U. Studies on the phytochemistry and bioactivity of leaves of trees in Chennai-I.Int. J. Chemtech Res.2014640784083
    [Google Scholar]
  41. RudrappaM. RudayniH.A. AssiriR.A. BepariA. BasavarajappaD.S. NagarajaS.K. ChakrabortyB. SwamyP.S. AgadiS.N. NiaziS.K. NayakaS. Plumeria alba-mediated green synthesis of silver nanoparticles exhibits antimicrobial effect and anti-oncogenic activity against glioblastoma U118 MG cancer cell line.Nanomaterials202212349310.3390/nano12030493 35159838
    [Google Scholar]
  42. LotankarA.R. MominA.J. WankhedeS. SharmaJ.B. Anti-inflammatory activity of an ornamental plant Plumeria obtusa.Adv. Pharmacol. Pharm.201643232610.13189/app.2016.040301
    [Google Scholar]
/content/journals/cbc/10.2174/0115734072350755250219104056
Loading
/content/journals/cbc/10.2174/0115734072350755250219104056
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test