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image of Diosmin as Antidiabetic Agent: A Comprehensive Mechanistic Approach

Abstract

Diabetes mellitus is a chronic metabolic disorder which occurs due to deficiency of insulin or resistance to insulin receptor. There are naturally occurring compounds found in various plants, foods, and herbs that have potent anti-diabetic properties. They help to control blood sugar levels by increasing insulin sensitivity and stimulating glucose absorption in cells. Diosmin, a flavonoid glycoside found primarily in citrus fruits, has shown outstanding potential as a therapeutic agent due to its significant anti-diabetic, anti-inflammatory, antioxidant, and vascular-protective properties. Here, we review the diosmin molecular mechanism and its ability to regulate oxidative stress, reduce inflammatory cytokines, improve endothelial function, and explore its pathway for anti-diabetic properties. In addition, preclinical and clinical data that supports diosmin efficacy in decreasing blood glucose, enhancing insulin sensitivity, and delaying the development of diabetic squeal was considered. Furthermore, diosmin has shown great potential in a variety of therapeutic domains when associated with other drugs in combinational studies, and many diosmin-based drug delivery studies have been reported. This review also investigates the molecular processes and clinical uses of diosmin, emphasizing its therapeutic potential as an additional drug in diabetes control through a comprehensive review of current studies.

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2025-01-23
2025-09-28

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Diosmin as Antidiabetic Agent: A Comprehensive Mechanistic Approach
Bentham Science Publishers ; https://doi.org/10.2174/0115734072348359250115072824
/content/journals/cbc/10.2174/0115734072348359250115072824
/content/journals/cbc/10.2174/0115734072348359250115072824
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  • Article Type:     Review Article
Keywords: NF-κB ; AMPK ; diabetes mellitus ; insulin signaling ; Diosmin ; GLUT

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