Skip to content
2000
image of Hybrid Cosmeceutical Innovations for Aging Skin: Bridging Functional Skincare and Therapeutic Benefits through Multifunctional Formulations

Abstract

A new generation of hybrid cosmetics has come into existence, providing an efficient means to achieve both skincare and aesthetic objectives with only one product. These cosmetics incorporate ingredients from natural and synthetic sources, making use of cutting-edge technologies to improve efficacy, sustainability, and customer pleasure. This review paper will focus on the effects of hybrid cosmetics on different types of skin cells, the technologies employed, and the role of ingredients like botanical extracts, marine-based active ingredients, and synthetic compounds in the cosmetic formulations, in order to provide improved skincare benefits. Various technologies like nanotechnology, encapsulation technique, transdermal patches, electroporation, and iontophoresis are analyzed for their role in enhancing efficacy and sustainability. Hybrid cosmetics containing natural ingredients of marine origin, like and , as well as botanical extracts like Resveratrol, provide safe, eco-friendly, and sustainable cosmetics, whereas synthetically derived compounds that are used in the cosmetic industry, like Hyaluronic acid and Niacinamide, provide quick action and targeted delivery. The findings of this review suggest novel dual approaches for developing a range of hybrid products to meet the increasing needs of consumers, as well as techniques for improving stability and efficacy. Using natural ingredients aligns with the growing trend toward sustainability in cosmetics. Synthetic ingredients have been developed for precise delivery, rapid action, and affordability. However, by implementing appropriate strategies for technology and ingredient selection, consumers' demands for effective products can be met.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cas/10.2174/0118746098369285250902044905
2025-09-17
2025-12-20

  • From This Site

    /content/journals/cas/10.2174/0118746098369285250902044905
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Li M. Wang L. Wang M. Zhao H. Zhao F. Advances on hormones in cosmetics: Illegal addition status, sample preparation, and detection technology. Molecules 2023 28 4 1980 10.3390/molecules28041980 36838967
    [Google Scholar]
  2. Becchetti-Gonon L Blanche C Managing challenges of new product development projects in a hybrid work setting: Case study in the cosmetic industry 2024
  3. Celeiro M. Garcia-Jares C. Llompart M. Lores M. Recent advances in sample preparation for cosmetics and personal care products analysis. Molecules 2021 26 16 4900 10.3390/molecules26164900 34443488
    [Google Scholar]
  4. Cosmetics market size, share and growth report 2024 Available from: https://www.grandviewresearch.com/industry-analysis/cosmetics-market
  5. Duarte M. Oliveira A.L. Oliveira C. Pintado M. Amaro A. Madureira A.R. Current postbiotics in the cosmetic market—an update and development opportunities. Appl. Microbiol. Biotechnol. 2022 106 18 5879 5891 10.1007/s00253‑022‑12116‑5 36008565
    [Google Scholar]
  6. Dhapte-Pawar V. Kadam S. Saptarsi S. Kenjale P.P. Nanocosmeceuticals: Facets and aspects. Future Sci. OA 2020 6 10 FSO613 10.2144/fsoa‑2019‑0109 33312696
    [Google Scholar]
  7. Kolling C. Ribeiro J.L.D. Morea D. Iazzolino G. Corporate social responsibility and circular economy from the perspective of consumers: A cross‐cultural analysis in the cosmetic industry. Corp. Soc. Resp. Environ. Manag. 2023 30 3 1226 1243 10.1002/csr.2415
    [Google Scholar]
  8. McMullen R.L. Dell’Acqua G. History of natural ingredients in cosmetics. Cosmetics 2023 10 3 71 10.3390/cosmetics10030071
    [Google Scholar]
  9. Goyal N. Jerold F. Biocosmetics: Technological advances and future outlook. Environ. Sci. Pollut. Res. Int. 2021 30 10 25148 25169 10.1007/s11356‑021‑17567‑3 34825334
    [Google Scholar]
  10. Kumari S. Pal B. Tewari D. Sahu S.K. Cosmetics utilization and associated adverse events: A community based cross-sectional study. Clin. Epidemiol. Glob. Health 2023 23 101382 10.1016/j.cegh.2023.101382
    [Google Scholar]
  11. Nagpal G. Chaudhary R. Chaudhary R.G. Singh N.B. Emerging trends of nanotechnology in cosmetics. Mater Res Found 2023 148 127 169 10.21741/9781644902554‑5
    [Google Scholar]
  12. Liu Y. Zhao J. Chen J. Miao X. Nanocrystals in cosmetics and cosmeceuticals by topical delivery. Colloids Surf. B Biointerfaces 2023 227 113385 10.1016/j.colsurfb.2023.113385 37270904
    [Google Scholar]
  13. Awan U.A. Saeed R.F. Ismail H. Abidin SZ.U. Ali J.S. Bhatti M.Z. Emerging trends of nanotechnology-based advanced cosmeceuticals. J Surf Sci Nanotechnol 2023 22 2 86 97
    [Google Scholar]
  14. Santos A.C. Morais F. Simões A. Nanotechnology for the development of new cosmetic formulations. Expert Opin. Drug Deliv. 2019 16 4 313 330 10.1080/17425247.2019.1585426 30793641
    [Google Scholar]
  15. Mahajan K. Sharma P. Abbot V. Chauhan K. Ethosomes as a carrier for transdermal drug delivery system: Methodology and recent developments. J. Liposome Res. 2024 34 4 697 714 10.1080/08982104.2024.2339896 38676416
    [Google Scholar]
  16. Vieira M.V. Pastrana L.M. Fuciños P. Microalgae encapsulation systems for food, pharmaceutical and cosmetics applications. Mar. Drugs 2020 18 12 644 10.3390/md18120644 33333921
    [Google Scholar]
  17. Lunter D. Klang V. Eichner A. Progress in topical and transdermal drug delivery research—focus on nanoformulations. Pharmaceutics 2024 16 6 817 10.3390/pharmaceutics16060817 38931938
    [Google Scholar]
  18. Rotake S B Hatwar P R Bakal R L Kohale N B Transdermal drug delivery system recent advancements: A comprehensive review. GSC Biol Pharm Sci 2024 28 2 059 72
    [Google Scholar]
  19. Rahamathulla M. Murugesan S. Gowda D.V. The use of nanoneedles in drug delivery: An overview of recent trends and applications. AAPS PharmSciTech 2023 24 8 216 10.1208/s12249‑023‑02661‑1 37857918
    [Google Scholar]
  20. Bouslimani A. da Silva R. Kosciolek T. The impact of skin care products on skin chemistry and microbiome dynamics. BMC Biol. 2019 17 1 47 10.1186/s12915‑019‑0660‑6 31189482
    [Google Scholar]
  21. Abu-Huwaij R. Zidan A.N. Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review. J. Cosmet. Dermatol. 2024 23 1 17 26 10.1111/jocd.15895 37393573
    [Google Scholar]
  22. Bialas I. Zelent-Kraciuk S. Jurowski K. The skin sensitisation of cosmetic ingredients: Review of actual regulatory status. Toxics 2023 11 4 392 10.3390/toxics11040392 37112619
    [Google Scholar]
  23. Nicolai S. Wegrecki M. Cheng T.Y. Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products. Sci. Immunol. 2020 5 43 eaax5430 10.1126/sciimmunol.aax5430 31901073
    [Google Scholar]
  24. Johnson L. Aglas L. Punz B. Mechanistic insights into silica nanoparticle–allergen interactions on antigen presenting cell function in the context of allergic reactions. Nanoscale 2023 15 5 2262 2275 10.1039/D2NR05181H 36630186
    [Google Scholar]
  25. Fehres C.M. Bruijns S.C.M. Sotthewes B.N. Phenotypic and functional properties of human steady state CD14+ and CD1a+ antigen presenting cells and epidermal Langerhans cells. PLoS One 2015 10 11 e0143519 10.1371/journal.pone.0143519 26605924
    [Google Scholar]
  26. Głaz P. Rosińska A. Woźniak S. Boguszewska-Czubara A. Biernasiuk A. Matosiuk D. Effect of commonly used cosmetic preservatives on healthy human skin cells. Cells 2023 12 7 1076 10.3390/cells12071076 37048149
    [Google Scholar]
  27. Massaro L. De Sanctis S. Franchini V. Study of genotoxic and cytotoxic effects induced in human fibroblasts by exposure to pulsed and continuous 1.6 GHz radiofrequency. Front. Public Health 2024 12 1419525 10.3389/fpubh.2024.1419525 39145180
    [Google Scholar]
  28. Hermosaningtyas A.A. Chanaj-Kaczmarek J. Kikowska M. Gornowicz-Porowska J. Budzianowska A. Pawlaczyk M. Potential of plant stem cells as helpful agents for skin disorders—a narrative review. Appl. Sci. 2024 14 16 7402 10.3390/app14167402
    [Google Scholar]
  29. Desai S S Mane V K Biotechnological advances in cosmetic industry. SustainProdInnovBioremediatomittedBiotechnol 2024 100 35 10.1002/9781119792888.ch3
    [Google Scholar]
  30. Yadwade R. Gharpure S. Ankamwar B. Nanotechnology in cosmetics pros and cons. Nano Express 2021 2 2 022003 10.1088/2632‑959X/abf46b
    [Google Scholar]
  31. Ginzburg A.L. Blackburn R.S. Santillan C. Truong L. Tanguay R.L. Hutchison J.E. Zinc oxide-induced changes to sunscreen ingredient efficacy and toxicity under UV irradiation. Photochem. Photobiol. Sci. 2021 20 10 1273 1285 10.1007/s43630‑021‑00101‑2 34647278
    [Google Scholar]
  32. Chakraborty S.S. Panja A. Dutta S. Patra P. Advancements in nanoparticles for skin care: A comprehensive review of properties, applications, and future perspectives. Discov Mater 2024 4 1 17 10.1007/s43939‑024‑00088‑4
    [Google Scholar]
  33. Bilal M. Iqbal H.M.N. New insights on unique features and role of nanostructured materials in cosmetics. Cosmetics 2020 7 2 24 10.3390/cosmetics7020024
    [Google Scholar]
  34. Dhiman S. Mannan A. Mehta D. Singh T.G. Nanodrug delivery systems for cosmetics. In: Nanotechnology and Drug Delivery. Jenny Stanford Publishing 2024 469 505
    [Google Scholar]
  35. Dubey S.K. Dey A. Singhvi G. Pandey M.M. Singh V. Kesharwani P. Emerging trends of nanotechnology in advanced cosmetics. Colloids Surf. B Biointerfaces 2022 214 112440 10.1016/j.colsurfb.2022.112440 35344873
    [Google Scholar]
  36. Prajapati A Kumar R. A comprehensive review of the use of nanoparticles in cosmeceutical science J Pharma Insights Res 2024 2 3 030 7 10.69613/rckvna64
    [Google Scholar]
  37. Xie Q. Liu G. Zhang Y. Edible films/coatings containing bioactive ingredients with micro/nano encapsulation: A comprehensive review of their fabrications, formulas, multifunctionality and applications in food packaging. Crit. Rev. Food Sci. Nutr. 2024 64 16 5341 5378 10.1080/10408398.2022.2153794 36503369
    [Google Scholar]
  38. Noore S. Pathania S. Fuciños P. O’Donnell C.P. Tiwari B.K. Nanocarriers for Controlled Release and Target Delivery of Bioactive Compounds. Springer Nature 2024 10.1007/978‑3‑031‑57488‑7
    [Google Scholar]
  39. da Silva A.F. Moreira A.F. Miguel S.P. Coutinho P. Recent advances in microalgae encapsulation techniques for biomedical applications. Adv. Colloid Interface Sci. 2024 333 103297 10.1016/j.cis.2024.103297 39226799
    [Google Scholar]
  40. Liu X. Dai H. Wang Z. Huang C. Huang K. Polyethylene glycol-stabilized cationic liposome encapsulating glucosamine sulfate: A promising nanoformulation for osteoarthritis therapy. AIP Adv. 2024 14 2 025137 10.1063/5.0189591
    [Google Scholar]
  41. Ashfaq A. Riaz T. Waqar M.A. Zaman M. Majeed I. A comprehensive review on transdermal patches as an efficient approach for the delivery of drug. Polymer-Plastics Technology and Materials 2024 63 8 1045 1069 10.1080/25740881.2024.2317408
    [Google Scholar]
  42. Kim B. Cho H.E. Moon S.H. Transdermal delivery systems in cosmetics. Biomed. Dermatol. 2020 4 1 12 10.1186/s41702‑019‑0053‑z
    [Google Scholar]
  43. Yilmaz E.G. Ece E. Erdem Ö. Eş I. Inci F. A sustainable solution to skin diseases: Ecofriendly transdermal patches. Pharmaceutics 2023 15 2 579 10.3390/pharmaceutics15020579 36839902
    [Google Scholar]
  44. Sabbagh F. Kim B.S. Recent advances in polymeric transdermal drug delivery systems. J. Control. Release 2022 341 132 146 10.1016/j.jconrel.2021.11.025 34813879
    [Google Scholar]
  45. Manousi E. Chatzitaki A.T. Vakirlis E. Karavasili C. Fatouros D.G. Development and in vivo evaluation of 3D printed hydrogel patches for personalized cosmetic use based on skin type. J. Drug Deliv. Sci. Technol. 2024 92 105306 10.1016/j.jddst.2023.105306
    [Google Scholar]
  46. Ho T.C. Chang C.C. Chan H.P. Hydrogels: Properties and applications in biomedicine. Molecules 2022 27 9 2902 10.3390/molecules27092902 35566251
    [Google Scholar]
  47. Chi J. Zhang X. Chen C. Shao C. Zhao Y. Wang Y. Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing. Bioact. Mater. 2020 5 2 253 259 10.1016/j.bioactmat.2020.02.004 32128464
    [Google Scholar]
  48. Pawar A.B. Falk B. Use of advanced silicone materials in long‐lasting cosmetics. In: Surf Sci Adhes Cosmet 2021 151 82 10.1002/9781119654926.ch5
    [Google Scholar]
  49. Yu L. Mazurek P. Madsen F.B. Skov A.L. Glycerol‐Filled silicone adhesive patches with excellent sun protection. Macromol. Mater. Eng. 2021 306 5 2000797 10.1002/mame.202000797
    [Google Scholar]
  50. Chun Y.Y. Tan W.W.R. Vos M.I.G. Scar prevention through topical delivery of gelatin-tyramine-siSPARC nanoplex loaded in dissolvable hyaluronic acid microneedle patch across skin barrier. Biomater. Sci. 2022 10 14 3963 3971 10.1039/D2BM00572G 35708018
    [Google Scholar]
  51. Liatsopoulou A. Varvaresou A. Mellou F. Protopapa E. Iontophoresis in dermal delivery: A review of applications in dermato‐cosmetic and aesthetic sciences. Int. J. Cosmet. Sci. 2023 45 2 117 132 10.1111/ics.12824 36326063
    [Google Scholar]
  52. Rols M.P. Golzio M. Teissié J. Electroporation: Technology and Science. In: Electroporation in Veterinary Oncology Practice: Electrochemotherapy and Gene Electrotransfer for Immunotherapy 2021 3 19
    [Google Scholar]
  53. Ita K. Perspectives on transdermal electroporation. Pharmaceutics 2016 8 1 9 10.3390/pharmaceutics8010009 26999191
    [Google Scholar]
  54. Liu J.K. Natural products in cosmetics. Nat. Prod. Bioprospect. 2022 12 1 40 10.1007/s13659‑022‑00363‑y 36437391
    [Google Scholar]
  55. Franca C.C.V. Ueno H.M. Green cosmetics: Perspectives and challenges in the context of green chemistry. Desenvolv. Meio Ambient. 2020 53 133 150 10.5380/dma.v53i0.62322
    [Google Scholar]
  56. Evolving beauty: The rise of sustainable and natural ingredients for cosmetics 2024 Available from: https://www.cas.org/resources/cas-insights/the-rise-of-natural-ingredients-for-cosmetics
  57. Goyal A. Sharma A. Kaur J. Bioactive-based cosmeceuticals: An update on emerging trends. Molecules 2022 27 3 828 10.3390/molecules27030828 35164093
    [Google Scholar]
  58. Alves A. Sousa E. Kijjoa A. Pinto M. Marine-derived compounds with potential use as cosmeceuticals and nutricosmetics. Molecules 2020 25 11 2536 10.3390/molecules25112536 32486036
    [Google Scholar]
  59. Fonseca S. Amaral M.N. Reis C.P. Custódio L. Marine natural products as innovative cosmetic ingredients. Mar. Drugs 2023 21 3 170 10.3390/md21030170 36976219
    [Google Scholar]
  60. Martins A.M. Marto J.M. A sustainable life cycle for cosmetics: From design and development to post-use phase. Sustain. Chem. Pharm. 2023 35 101178 10.1016/j.scp.2023.101178
    [Google Scholar]
  61. Resende D.I.S.P. Ferreira M. Magalhães C. Sousa Lobo J.M. Sousa E. Almeida I.F. Trends in the use of marine ingredients in anti-aging cosmetics. Algal Res. 2021 55 102273 10.1016/j.algal.2021.102273
    [Google Scholar]
  62. Choi J.S. Moon W.S. Choi J.N. Effects of seaweed Laminaria japonica extracts on skin moisturizing activity in vivo. J. Cosmet. Sci. 2013 64 3 193 205 23752034
    [Google Scholar]
  63. Li G. Li P. Tang X. Natural products from corals. In: Symbiotic Microbiomes of Coral Reefs Sponges and Corals 2019 465 504 10.1007/978‑94‑024‑1612‑1_16
    [Google Scholar]
  64. Sotelo C.G. Blanco M. Ramos P. Vázquez J.A. Perez-Martin R.I. Sustainable sources from aquatic organisms for cosmeceuticals ingredients. Cosmetics 2021 8 2 48 10.3390/cosmetics8020048
    [Google Scholar]
  65. Li P.H. Lu W.C. Chan Y.J. Extraction and characterization of collagen from sea cucumber (Holothuria cinerascens) and its potential application in moisturizing cosmetics. Aquaculture 2020 515 734590 10.1016/j.aquaculture.2019.734590
    [Google Scholar]
  66. Marinoa T. Iovinea A. Casellab P. Martinoc M. Chianesea S. Laroccac V. From Haematococcus pluvialis microalgae a powerful antioxidant for cosmetic applications. Chem. Eng. 2020 79 271 276
    [Google Scholar]
  67. Mularczyk M. Michalak I. Marycz K. Astaxanthin and other nutrients from Haematococcus pluvialis—Multifunctional applications. Mar. Drugs 2020 18 9 459 10.3390/md18090459 32906619
    [Google Scholar]
  68. Tamboli F.A. Kolekar Y.S. More H.N. Mulani S.A. Mali N.P. Medicinal plants used in cosmetics for skin and hair care. Int J Pharm Chem Anal 2021 8 2 36 40 10.18231/j.ijpca.2021.008
    [Google Scholar]
  69. Bashir R. Maqbool M. Zehravi M. Ara I. Utilization of herbal cosmetics: A brief overview. Adv J Chem Sect B 2021 3 277 288
    [Google Scholar]
  70. Bluemke A. Ring A.P. Immeyer J. Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing ‐ Experimental evidence for a holistic treatment approach. Int. J. Cosmet. Sci. 2022 44 3 377 393 10.1111/ics.12784 35514037
    [Google Scholar]
  71. Fidalgo J. Barros A.N. Casas A. Resveratrol: A promising antiaging agent for cosmetic skin treatments. In: Resveratrol - Recent Advances, Application, and Therapeutic Potential. IntechOpen 2024 10.5772/intechopen.107860
    [Google Scholar]
  72. Zhou D.D. Luo M. Huang S.Y. Effects and mechanisms of resveratrol on aging and age‐related diseases. Oxid. Med. Cell. Longev. 2021 2021 1 9932218 10.1155/2021/9932218 34336123
    [Google Scholar]
  73. Kalasariya H.S. Yadav V.K. Yadav K.K. Seaweed-based molecules and their potential biological activities: An eco-sustainable cosmetics. Molecules 2021 26 17 5313 10.3390/molecules26175313 34500745
    [Google Scholar]
  74. Bom S. Fitas M. Martins A.M. Pinto P. Ribeiro H.M. Marto J. Replacing synthetic ingredients by sustainable natural alternatives: A case study using topical O/W emulsions. Molecules 2020 25 21 4887 10.3390/molecules25214887 33105792
    [Google Scholar]
  75. Al-Halaseh L K Al-Jawabri N A Tarawneh S K A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid J Appl Pharm Sci 2022 12 7 034 41 10.7324/JAPS.2022.120703
    [Google Scholar]
  76. Boo Y.C. Mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation. Antioxidants 2021 10 8 1315 10.3390/antiox10081315 34439563
    [Google Scholar]
  77. Wiegmann D. Haddad L. Two is better than one: The combined effects of glycolic acid and salicylic acid on acne‐related disorders. J. Cosmet. Dermatol. 2020 19 9 2349 2351 10.1111/jocd.13387 32250551
    [Google Scholar]
  78. Zhao X. Zhang X. Liu D. Collagen peptides and the related synthetic peptides: A review on improving skin health. J. Funct. Foods 2021 86 104680 10.1016/j.jff.2021.104680
    [Google Scholar]
  79. Bukhari SNA Roswandi NL Waqas M Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol 2018 120 Pt B 1682 95 10.1016/j.ijbiomac.2018.09.188 30287361
    [Google Scholar]
  80. Juncan A.M. Moisă D.G. Santini A. Advantages of hyaluronic acid and its combination with other bioactive ingredients in cosmeceuticals. Molecules 2021 26 15 4429 10.3390/molecules26154429 34361586
    [Google Scholar]
  81. Ong R.R. Goh C.F. Niacinamide: A review on dermal delivery strategies and clinical evidence. Drug Deliv. Transl. Res. 2024 14 12 3512 3548 10.1007/s13346‑024‑01593‑y 38722460
    [Google Scholar]
  82. Marques C. Hadjab F. Porcello A. Mechanistic insights into the multiple functions of niacinamide: Therapeutic implications and cosmeceutical applications in functional skincare products. Antioxidants 2024 13 4 425 10.3390/antiox13040425 38671873
    [Google Scholar]
  83. Qian W. Liu W. Zhu D. Natural skin whitening compounds for the treatment of melanogenesis (Review) Exp. Ther. Med. 2020 20 1 173 185 10.3892/etm.2020.8687 32509007
    [Google Scholar]
  84. Sanchez C. Belleville P. Popall M. Nicole L. Applications of advanced hybrid organic–inorganic nanomaterials: From laboratory to market. Chem. Soc. Rev. 2011 40 2 696 753 10.1039/c0cs00136h 21229132
    [Google Scholar]
  85. De La Garza H. Visutjindaporn P. Maymone M.B.C. Vashi N.A. Tinted sunscreens: Consumer preferences based on light, medium, and dark skin tones. Cutis 2022 109 4 198 223 10.12788/cutis.0504 35659846
    [Google Scholar]
  86. Rähse W. Cosmetic creams: Development, manufacture and marketing of effective skin care products 2020
  87. Chavda V.P. Solanki H.K. Vaghela D.A. Prajapati K. Vora L.K. Nanotechnology-based face masks: Transforming the cosmetics landscape In: Micro MDPI 2025 5 11
    [Google Scholar]
  88. Badea N. Samayoa D. Moroşan A. Ott C. Lacatusu I. Hybrid carbohydrate–lipid nanocarriers: in vitro efficacy gene-rated by association of uv-absorbers and raspberry polyphenols rich-fraction. Pharmaceuticals 2024 18 1 16 10.3390/ph18010016 39861079
    [Google Scholar]
  89. Choudhary A. Chauhan S.B. Swami R. Singh I. Drug-Device combinations in dermatology: Integrating pharmaceuticals with advanced cosmetic technologies. Curr Cosmet Sci 2024 4 1 11 10.2174/0126667797340276241219105142
    [Google Scholar]
  90. Bhavsar J. Kasture K. Salvi B.V. Shende P. Strategies for transportation of peptides across the skin for treatment of multiple diseases. Ther. Deliv. 2025 16 1 63 86 10.1080/20415990.2024.2411943 39411995
    [Google Scholar]
  91. Han J. Choi Y.J. Kang S.K. Synergistic strategies of biomolecular transport technologies in transdermal healthcare systems. Adv. Healthc. Mater. 2024 13 30 2401753 10.1002/adhm.202401753 39087395
    [Google Scholar]
  92. Pintea A. Manea A. Pintea C. Peptides: Emerging candidates for the prevention and treatment of skin senescence: A Review. Biomolecules 2025 15 1 88 10.3390/biom15010088 39858482
    [Google Scholar]
  93. Bialik-Wąs K. Kulawik-Pióro A. Sienkiewicz A. Design and development of multibiocomponent hybrid alginate hydrogels and lipid nanodispersion as new materials for medical and cosmetic applications. Int. J. Biol. Macromol. 2024 278 Pt 1 134405 10.1016/j.ijbiomac.2024.134405 39116986
    [Google Scholar]
  94. Waller I Tahon A Unleashing cosmetic creativity with multifunctionality. SOFW J 2024 150 6 Available from: https://sofw.com/en/sofw-journal/articles-en/48-personal-care/4617-unleashing-cosmetic-creativity-with-multifunctionality
    [Google Scholar]
  95. Abouelkheir S.S. Elkhouly H.A. Mahmoud N.H. Application of marine resources for production of cosmetic products. In: Biomass Valorization: A Sustainable Approach towards Carbon Neutrality and Circular Economy. Singapore Springer Nature Singapore 2025 65 81
    [Google Scholar]
  96. Chakraborty R. Challenges and strategies in incorporating natural ingredients into. In: Eco-Friendly Skin Solutions for Natural Cosmeceuticals 2024 267
    [Google Scholar]
  97. Rasmi Y. Kirboğa K.K. Rao T. Ali M. Ahmed M.Z. Marine natural products as a bioresource for cosmeceuticals. Royal Society of Chemistry 2024 223 275 10.1039/9781837672288‑00223
    [Google Scholar]
  98. Ferrier M. Gémin M.P. Malinowska M.A. Metabolomics applications in natural cosmetics: Addressing the new challenges of bio-sourced ingredients. Phytochem. Rev. 2024 1 33 10.1007/s11101‑024‑10048‑8
    [Google Scholar]
  99. Gǎlbǎu C.Ş. Irimie M. Neculau A.E. The potential of plant extracts used in cosmetic product applications—antioxidants delivery and mechanism of actions. Antioxidants 2024 13 11 1425 10.3390/antiox13111425 39594566
    [Google Scholar]
  100. Klein G.M. The nature of skincare: Categorising cosmetics with bioactive ingredients in the case of quenty-cosmetic. Ambix 2025 72 1 47 57 10.1080/00026980.2025.2456889 39912778
    [Google Scholar]
  101. Leong H.J.Y. Teoh M.L. Beardall J. Convey P. Green beauty unveiled: Exploring the potential of microalgae for skin whitening, photoprotection and anti-aging applications in cosmetics. J. Appl. Phycol. 2024 36 6 3315 3328 10.1007/s10811‑024‑03345‑4
    [Google Scholar]
  102. Sergeeva Y.E. Kryukova M.V. Sukhinov D.V. Biomass of phototrophic microorganisms as a source of active components for cosmetics. Nanobiotechnology Reports 2024 19 6 901 911 10.1134/S2635167624601360
    [Google Scholar]
  103. Neytal P. Maji N. Maji S. Advances in cosmetic products towards a new future. In: Preserving Health, Preserving Earth: The Path to Sustainable Healthcare. Cham Springer Nature Switzerland 2024 193 214 10.1007/978‑3‑031‑60545‑1_12
    [Google Scholar]
  104. Du X.N. He Y. Chen Y.W. Decoding cosmetic complexities: A comprehensive guide to matrix composition and pretreatment technology. Molecules 2024 29 2 411 10.3390/molecules29020411 38257324
    [Google Scholar]
  105. Hoogstraaten M.J. Boon W.P.C. Frenken K. How product development partnerships support hybrid collaborations dealing with global health challenges. Glob. Transit. 2020 2 190 201 10.1016/j.glt.2020.09.002
    [Google Scholar]
  106. Łętocha A. Miastkowska M. Sikora E. Michalczyk A. Liszka-Skoczylas M. Witczak M. Hybrid systems of oleogels and probiotic-loaded alginate carriers for potential application in cosmetics. Molecules 2024 29 24 5984 10.3390/molecules29245984 39770073
    [Google Scholar]
  107. Adilbekova A. Marassulov S. Baigenzhin A. Hybrid versus traditional method closure of ventricular septal defects in children. JTCVS Tech 2024 24 137 144 10.1016/j.xjtc.2024.01.015 38835571
    [Google Scholar]
  108. Goldust M. Baumann L. Gold M.H. Landau M. Advancements in cosmetics and aesthetics: A comprehensive review. Dermatol. Rev. 2024 5 4 e245 10.1002/der2.245
    [Google Scholar]
  109. Skiba R. Advances in Cosmetology: Beauty Therapy Technology, Treatments, Sustainability, and Holistic Wellness. After Midnight Publishing 2025
    [Google Scholar]
  110. Alves P.L.M. Nieri V. Moreli F.C. Unveiling new horizons: Advancing technologies in cosmeceuticals for anti-aging solutions. Molecules 2024 29 20 4890 10.3390/molecules29204890 39459258
    [Google Scholar]
  111. Manful M.E. Ahmed L. Barry-Ryan C. Cosmetic formulations from natural sources: Safety considerations and legislative frameworks in the European Union. Cosmetics 2024 11 3 72 10.3390/cosmetics11030072
    [Google Scholar]
  112. Shastri D.H. Gandhi S. Almeida H. Enhancing Collaboration and Interdisciplinary Strategies for Navigating Innovative Technologies and Regulatory Approvals in the Cosmetic Industry. Current Cosmetic Science 2024 10.2174/0126667797324383240913033156
    [Google Scholar]
  113. Habibzadeh S. Astaraei F.R. Jahangir M.H. Sustainability assessment of a petrochemical plant electricity supply based on 4E optimization of various hybrid renewable energy systems scenarios. Energy Convers. Manage. 2025 325 119357 10.1016/j.enconman.2024.119357
    [Google Scholar]
  114. Barthe M. Bavoux C. Finot F. Safety testing of cosmetic products: Overview of established methods and new approach methodologies (NAMs). Cosmetics 2021 8 2 50 10.3390/cosmetics8020050
    [Google Scholar]
  115. Rana P. Pathania D. Gaur P. Regulatory frameworks for fragrance safety in cosmetics: A global overview. Toxicol. Res. 2025 41 3 199 220 10.1007/s43188‑025‑00283‑2 40291114
    [Google Scholar]
  116. Isibor P.O. Regulations and policy considerations for nanoparticle safety. In: Environmental Nanotoxicology: Combatting the Minute Contaminants. Cham Springer Nature Switzerland 2024 295 316 10.1007/978‑3‑031‑54154‑4_14
    [Google Scholar]
  117. Achagar R. Ait-Touchente Z. El Ati R. A comprehensive review of essential oil–nanotechnology synergy for advanced Dermocosmetic delivery. Cosmetics 2024 11 2 48 10.3390/cosmetics11020048
    [Google Scholar]
/content/journals/cas/10.2174/0118746098369285250902044905
Loading
Hybrid Cosmeceutical Innovations for Aging Skin: Bridging Functional Skincare and Therapeutic Benefits through Multifunctional Formulations
Bentham Science Publishers ; https://doi.org/10.2174/0118746098369285250902044905
/content/journals/cas/10.2174/0118746098369285250902044905
/content/journals/cas/10.2174/0118746098369285250902044905
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: aging ; Hybrid cosmetics ; encapsulation ; cosmetics ; marine extracts ; nanotechnology ; skincare ; botanical extract

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test