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image of Nanotechnology-Based Approaches for Combating Skin Aging: A Comprehensive Review

Abstract

Introduction

The aging of skin is a multifaceted biological phenomenon influenced by both intrinsic and extrinsic factors. As awareness among the public increases, there is a growing interest in natural ingredients and cutting-edge cosmetic solutions that enhance skin appearance and mitigate the aging process. Nanotechnology has emerged as a significant field within cosmeceuticals, providing innovative solutions that overcome the limitations of conventional cosmetic formulations by enhancing delivery, stability, and targeted efficacy.

Methods

This review synthesized contemporary research on nanotechnology-driven approaches utilized in anti-aging skincare. A comprehensive search of scientific databases, including PubMed, Scopus, and Google Scholar, was performed to identify research articles and review papers using keywords, such as “nanotechnology,” “skin aging,” “anti-aging cosmetics,” “nanocarriers,” and “bioactive compounds.” The emphasis was placed on studies that highlight nanosized delivery systems and their mechanisms in addressing issues related to skin aging.

Results

Bioactive compounds targeting anti-aging, such as antioxidants (including ascorbic acid, alpha-tocopherol, lipoic acid, and coenzyme Q10) and plant extracts (such as green tea, turmeric, and resveratrol), were successfully integrated into nanocarrier systems. These systems, comprising lipid nanoparticles, polymeric carriers, nanoemulsions, dendrimers, and fullerenes, demonstrate improved penetration, stability, and controlled release compared to traditional formulations, thereby enhancing the effectiveness of active ingredients in addressing signs of aging.

Discussion

Nanotechnology-driven skincare has demonstrated enhanced delivery, stability, and bioavailability of anti-aging compounds, addressing limitations of conventional formulations. Nanosized carriers improve penetration and controlled release, optimizing the functional benefits of antioxidants and botanical extracts. However, concerns related to safety, toxicity, and regulatory compliance require further investigation. Sustainable nanocarrier development and interdisciplinary collaborations will be essential for balancing efficacy with safety. Continued research will be crucial to establishing standardized guidelines and ensuring the successful commercialization of nano-based anti-aging cosmetics.

Conclusion

Nanotechnology presents significant potential for the development of effective anti-aging cosmetic products. The use of nanosized delivery systems significantly enhances the efficacy of active ingredients, providing a viable alternative to traditional formulations. Nonetheless, challenges related to safety, toxicity, regulatory compliance, and long-term clinical application must be addressed in future research to facilitate the successful commercialization of these products. Additionally, future investigations should consider sustainable practices.

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2026-03-02

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References

  1. Raj S. Jose S. Sumod U.S. Sabitha M. Nanotechnology in cosmetics: Opportunities and challenges. J. Pharm. Bioallied Sci. 2012 4 3 186 193 10.4103/0975‑7406.99016 22923959
    [Google Scholar]
  2. Kaul S. Gulati N. Verma D. Mukherjee S. Nagaich U. Role of nanotechnology in cosmeceuticals: A review of recent advances. J. Pharm. 2018 2018 1 19 10.1155/2018/3420204 29785318
    [Google Scholar]
  3. Ajazzuddin M. Jeswani G. Jha A. Jha A.K. Nanocosmetics: Past, present and future trends. Recent Pat. Nanomed. 2015 5 1 3 11 10.2174/1877912305666150417232826
    [Google Scholar]
  4. Gupta V. Mohapatra S. Mishra H. Nanotechnology in cosmetics and cosmeceuticals—a review of latest advancements. Gels 2022 8 3 173 10.3390/gels8030173 35323286
    [Google Scholar]
  5. Vaiserman A. Koliada A. Lushchak O. Phyto-nanotechnology in anti-aging medicine. Aging 2021 13 8 10818 10820 10.18632/aging.203026 33910168
    [Google Scholar]
  6. Santos A.C. Morais F. Simões A. Nanotechnology for the development of new cosmetic formulations. Expert Opin. Drug Deliv. 2019 16 4 313 330 10.1080/17425247.2019.1585426 30793641
    [Google Scholar]
  7. Dhawan S. Sharma P. Nanda S. Cosmetic nanoformulations and their intended use. In: Nanocosmetics. Elsevier 2020 141 169 10.1016/B978‑0‑12‑822286‑7.00017‑6
    [Google Scholar]
  8. Zhu S Jia L Wang X Liu T Qin W Ma H Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression. J Ethnopharmacol 2024 318 Pt B 116996 10.1016/j.jep.2023.116996 37598772
    [Google Scholar]
  9. Bolzinger M.A. Briançon S. Pelletier J. Chevalier Y. Penetration of drugs through skin, a complex rate-controlling membrane. Curr. Opin. Colloid Interface Sci. 2012 17 3 156 165 10.1016/j.cocis.2012.02.001
    [Google Scholar]
  10. Kolarsick P.A.J. Kolarsick M.A. Goodwin C. Anatomy and physiology of the skin. J. Dermatol. Nurses Assoc. 2011 3 4 203 213 10.1097/JDN.0b013e3182274a98
    [Google Scholar]
  11. Rani S. Dey P. Pruthi K. Nanotechnology-based approaches for cosmeceutical and skin care: A systematic review. Crit. Rev. Ther. Drug Carrier Syst. 2024 41 5 65 110 10.1615/CritRevTherDrugCarrierSyst.v41.i5.20 38608133
    [Google Scholar]
  12. Wong Q.Y.A. Chew F.T. Defining skin aging and its risk factors: A systematic review and meta-analysis. Sci. Rep. 2021 11 1 22075 10.1038/s41598‑021‑01573‑z 34764376
    [Google Scholar]
  13. Papaccio F.D. Arino A. Caputo S. Bellei B. Focus on the contribution of oxidative stress in skin aging. Antioxidants 2022 11 6 1121 10.3390/antiox11061121 35740018
    [Google Scholar]
  14. Shin S.H. Lee Y.H. Rho N.K. Park K.Y. Skin aging from mechanisms to interventions: Focusing on dermal aging. Front. Physiol. 2023 14 1195272 10.3389/fphys.2023.1195272 37234413
    [Google Scholar]
  15. Bakry R. Vallant R.M. Najam-ul-Haq M. Medicinal applications of fullerenes. Int. J. Nanomedicine 2007 2 4 639 649 18203430
    [Google Scholar]
  16. Bhattacharjee S. Rastogi V. Durgapal S. Verma A. Singh B. Chandra A. Nanotherapy targeting anti-aging skin cells: Harnessing ursolic acid from Ocimum sanctum Linn for precision skin rejuvenation – a molecular perspective. Nat. Prod. Res. 2025 1 16 10.1080/14786419.2025.2474157 40047211
    [Google Scholar]
  17. Kandekar S.G. del Río-Sancho S. Lapteva M. Kalia Y.N. Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers. Nanoscale 2018 10 3 1099 1110 10.1039/C7NR07706H 29271454
    [Google Scholar]
  18. Csekes E. Račková L. Skin aging, cellular senescence and natural polyphenols. Int. J. Mol. Sci. 2021 22 23 12641 10.3390/ijms222312641 34884444
    [Google Scholar]
  19. Husni P. Eryani M.C. Topical formulation of herbal nanocosmetics for anti-aging. Indones. J. Pharm. 2025 6 2 109 118
    [Google Scholar]
  20. Shori S. Wahi A. Raina N. Rani R. Chauhan D.N. Gupta M. Novel phytopharmaceuticals: A promising era for antiaging. In: Novel Phytopharmaceutical for Management of Disorders. CRC Press 2024 332 348 10.1201/9781003292692‑14
    [Google Scholar]
  21. Domínguez-Delgado C.L. Pozos-Nonato S. Campos-Santander K.A. Novel nanotechnological strategies for skin anti-aging. Curr. Pharm. Biotechnol. 2023 24 11 1397 1419 10.2174/1389201024666221223095315 36567280
    [Google Scholar]
  22. Chauhan A. Chauhan C. Emerging trends of nanotechnology in beauty solutions: A review. Mater. Today Proc. 2023 81 1052 1059 10.1016/j.matpr.2021.04.378
    [Google Scholar]
  23. Raszewska-Famielec M. Flieger J. Nanoparticles for topical application in the treatment of skin dysfunctions—an overview of dermo-cosmetic and dermatological products. Int. J. Mol. Sci. 2022 23 24 15980 10.3390/ijms232415980 36555619
    [Google Scholar]
  24. Kwon Y.S. Zheng M. Zhang A.Y. Han Z. Melanin-like nanoparticles as an alternative to natural melanin in retinal pigment epithelium cells and their therapeutic effects against age-related macular degeneration. ACS Nano 2022 16 11 19412 19422 10.1021/acsnano.2c09087 36269679
    [Google Scholar]
  25. Bhatia E. Kumari D. Sharma S. Ahamad N. Banerjee R. Nanoparticle platforms for dermal antiaging technologies: Insights in cellular and molecular mechanisms. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2022 14 2 e1746 10.1002/wnan.1746 34423571
    [Google Scholar]
  26. He X. Gao X. Xie W. Research progress in skin aging, metabolism, and related products. Int. J. Mol. Sci. 2023 24 21 15930 10.3390/ijms242115930 37958920
    [Google Scholar]
  27. Son M.H. Park S.W. Jung Y.K. Antioxidant and anti-aging carbon quantum dots using tannic acid. Nanotechnology 2021 32 41 415102 10.1088/1361‑6528/ac027b 34297003
    [Google Scholar]
  28. Wu Y.Z. Tsai Y.Y. Chang L.S. Chen Y.J. Evaluation of gallic acid-coated gold nanoparticles as an anti-aging ingredient. Pharmaceuticals 2021 14 11 1071 10.3390/ph14111071 34832853
    [Google Scholar]
  29. Mortazavi S.M. Moghimi H.R. Skin permeability, a dismissed necessity for anti‐wrinkle peptide performance. Int. J. Cosmet. Sci. 2022 44 2 232 248 10.1111/ics.12770 35302659
    [Google Scholar]
  30. Puizina-Ivić N. Skin aging. Acta Dermatovenerol. Alp. Panonica Adriat. 2008 17 2 47 54 18709289
    [Google Scholar]
  31. Cardoza C. Nagtode V. Pratap A. Mali S.N. Emerging applications of nanotechnology in cosmeceutical health science: Latest updates. Health Sci. Rep. 2022 4 100051 10.1016/j.hsr.2022.100051
    [Google Scholar]
  32. Abu Hajleh M.N. Abu-Huwaij R. AL-Samydai A, Al-Halaseh LK, Al-Dujaili EA. The revolution of cosmeceuticals delivery by using nanotechnology: A narrative review of advantages and side effects. J. Cosmet. Dermatol. 2021 20 12 3818 3828 10.1111/jocd.14441 34510691
    [Google Scholar]
  33. Ahmad J. Lipid nanoparticles-based cosmetics with potential application in alleviating skin disorders. Cosmetics 2021 8 3 84 10.3390/cosmetics8030084
    [Google Scholar]
  34. Krutmann J. Schikowski T. Morita A. Berneburg M. Environmentally-induced (extrinsic) skin aging: Exposomal factors and underlying mechanisms. J. Invest. Dermatol. 2021 141 4 1096 1103 10.1016/j.jid.2020.12.011 33541724
    [Google Scholar]
  35. Kim J.C. Park T.J. Kang H.Y. Skin-aging pigmentation: Who is the real enemy? Cells 2022 11 16 2541 10.3390/cells11162541 36010618
    [Google Scholar]
  36. Bravo B. Correia P. Gonçalves J.E. Junior Sant’Anna B. Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatol. Ther. 2022 35 12 e15903 10.1111/dth.15903 36200921
    [Google Scholar]
  37. Ho C.Y. Dreesen O. Faces of cellular senescence in skin aging. Mech. Ageing Dev. 2021 198 111525 10.1016/j.mad.2021.111525 34166688
    [Google Scholar]
  38. Zou Z. Long X. Zhao Q. A single-cell transcriptomic atlas of human skin aging. Dev. Cell 2021 56 3 383 397.e8 10.1016/j.devcel.2020.11.002 33238152
    [Google Scholar]
  39. Lee A.Y. Skin pigmentation abnormalities and their possible relationship with skin aging. Int. J. Mol. Sci. 2021 22 7 3727 10.3390/ijms22073727 33918445
    [Google Scholar]
  40. Wlaschek M. Maity P. Makrantonaki E. Scharffetter-Kochanek K. Connective tissue and fibroblast senescence in skin aging. J. Invest. Dermatol. 2021 141 4 985 992 10.1016/j.jid.2020.11.010 33563466
    [Google Scholar]
  41. Martic I. Jansen-Dürr P. Cavinato M. Effects of air pollution on cellular senescence and skin aging. Cells 2022 11 14 2220 10.3390/cells11142220 35883663
    [Google Scholar]
  42. He X. Gao X. Xie W. Research progress in skin aging and immunity. Int. J. Mol. Sci. 2024 25 7 4101 10.3390/ijms25074101 38612909
    [Google Scholar]
  43. Wyles S.P. Carruthers J.D. Dashti P. Cellular senescence in human skin aging: Leveraging senotherapeutics. Gerontology 2024 70 1 7 14 10.1159/000534756 37879300
    [Google Scholar]
  44. Achagar R. Ait-Touchente Z. El Ati R. A comprehensive review of essential oil–nanotechnology synergy for advanced dermocosmetic delivery. Cosmetics 2024 11 2 48 10.3390/cosmetics11020048
    [Google Scholar]
  45. Hegde A.R. Kunder M.U. Narayanaswamy M. Advancements in sunscreen formulations: Integrating polyphenolic nanocarriers and nanotechnology for enhanced UV protection. Environ. Sci. Pollut. Res. Int. 2024 31 26 38061 38082 10.1007/s11356‑024‑33712‑0 38806984
    [Google Scholar]
  46. Sghier K. Mur M. Veiga F. Paiva-Santos A.C. Pires P.C. Novel therapeutic hybrid systems using hydrogels and nanotechnology: A focus on nanoemulgels for the treatment of skin diseases. Gels 2024 10 1 45 10.3390/gels10010045 38247768
    [Google Scholar]
  47. Jin S. Wang Y. Wu X. Young exosome bio-nanoparticles restore aging-impaired tendon stem/progenitor cell function and reparative capacity. Adv. Mater. 2023 35 18 2211602 10.1002/adma.202211602 36779444
    [Google Scholar]
  48. Mascarenhas-Melo F. Ribeiro M.M. Kahkesh K.H. Comprehensive review of the skin use of bakuchiol: Physicochemical properties, sources, bioactivities, nanotechnology delivery systems, regulatory and toxicological concerns. Phytochem. Rev. 2024 23 5 1377 1413 10.1007/s11101‑024‑09926‑y
    [Google Scholar]
  49. Foteva T. Nanotechnology in the cosmetic industry. J Chem Technol Metall 2023 59 1 3 14 10.59957/jctm.v59.i1.2024.1
    [Google Scholar]
  50. Tekinay S.H. Nanomaterials for skin anti-aging. Eur. Polym. J. 2024 217 113311 10.1016/j.eurpolymj.2024.113311
    [Google Scholar]
  51. Pan X. Zhou H. Li Z. Application and safety research of nanotechnology in cosmetics: Current status, challenges, and future prospects. Bionanoscience 2025 15 2 284 10.1007/s12668‑025‑01884‑9
    [Google Scholar]
  52. Santhiya P. Sulochana R.L. Swathi M. Ganesan V. The impact of nanotechnology on cosmeceuticals. J. Pharm. 2024 2 2
    [Google Scholar]
  53. Mohsin N. de la Caridad Hernandez L.E. Eckembrecher F.J. Eckembrecher D.G. Nouri K. The applications of nanotechnology in dermatology. In: Telemedicine and Technological Advances in Dermatology. Cham Springer Nature Switzerland 2024 375 385 10.1007/978‑3‑031‑69091‑4_26
    [Google Scholar]
  54. Chauhan D. Yadav P.K. Sultana N. Advancements in nanotechnology for the delivery of phytochemicals. J. Integr. Med. 2024 22 4 385 398 10.1016/j.joim.2024.04.005 38693014
    [Google Scholar]
  55. van Deursen J.M. The role of senescent cells in ageing. Nature 2014 509 7501 439 446 10.1038/nature13193 24848057
    [Google Scholar]
  56. Palmer D.M. Kitchin J.S. Oxidative damage, skin aging, antioxidants and a novel antioxidant rating system. J. Drugs Dermatol. 2010 9 1 11 15 20120419
    [Google Scholar]
  57. Kennedy C. Bastiaens M.T. Willemze R. Bouwes Bavinck J.N. Bajdik C.D. Westendorp R.G.J. Effect of smoking and sun on the aging skin. J. Invest. Dermatol. 2003 120 4 548 554 10.1046/j.1523‑1747.2003.12092.x 12648216
    [Google Scholar]
  58. Pillai S. Oresajo C. Hayward J. Ultraviolet radiation and skin aging: Roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation‐induced matrix degradation – A review. Int. J. Cosmet. Sci. 2005 27 1 17 34 10.1111/j.1467‑2494.2004.00241.x 18492178
    [Google Scholar]
  59. Pittayapruek P. Meephansan J. Prapapan O. Komine M. Ohtsuki M. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int. J. Mol. Sci. 2016 17 6 868 10.3390/ijms17060868 27271600
    [Google Scholar]
  60. Gkogkolou P. Böhm M. Advanced glycation end products. Dermatoendocrinol 2012 4 3 259 270 10.4161/derm.22028 23467327
    [Google Scholar]
  61. Helfrich Y.R. Sachs D.L. Voorhees J.J. Overview of skin aging and photoaging. Dermatol. Nurs. 2008 20 3 177 183 18649702
    [Google Scholar]
  62. Yarosh D. The new science of perfect skin: understanding skin care myths and miracles for radiant skin at any age. Harmony 2008
    [Google Scholar]
  63. Nazarko L. Part one: Consequences of ageing and illness on skin. Nurs Res Care 2005 7 6 255 257 10.12968/nrec.2005.7.6.18219
    [Google Scholar]
  64. Banihashemi M. Zabolinejad N. Jaafari M.R. Salehi M. Jabari A. Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma. J. Cosmet. Dermatol. 2015 14 3 174 177 10.1111/jocd.12152 26177992
    [Google Scholar]
  65. Nascimento L.V. Enveloping Tips. In: Aesthetic Dermatology. São Paulo Atheneu 2009 53 56
    [Google Scholar]
  66. Friedman O. Changes associated with the aging face. Facial Plast. Surg. Clin. North Am. 2005 13 3 371 380 10.1016/j.fsc.2005.04.004 16085282
    [Google Scholar]
  67. Neill U.S. Skin care in the aging female: Myths and truths. J. Clin. Invest. 2012 122 2 473 477 10.1172/JCI61978 22293186
    [Google Scholar]
  68. Rabe J.H. Mamelak A.J. McElgunn P.J.S. Morison W.L. Sauder D.N. Photoaging: Mechanisms and repair. J. Am. Acad. Dermatol. 2006 55 1 1 19 10.1016/j.jaad.2005.05.010 16781287
    [Google Scholar]
  69. Yapar E.A. Tanrıverdi S.T. Anti-aging cosmetic approaches and product ingredients. Balıkesir Sağlık Bilimleri Dergisi 2016 5 99 109
    [Google Scholar]
  70. Tursen U. Skin aging prevention with topical agents. Dermatose 2006 4 267 283
    [Google Scholar]
  71. Tırnaksız F. Use of antioxidants in skin care herbs. Table of Contents Education Course. Kasım 2005 26 37
    [Google Scholar]
  72. Wickett R.R. Visscher M.O. Structure and function of the epidermal barrier. Am. J. Infect. Control 2006 34 10 S98 S110 10.1016/j.ajic.2006.05.295
    [Google Scholar]
  73. Yazan Y. Dermacosmetics/cosmeceutical substances and products. Istanbul Nobel Medical Bookstores 2016
    [Google Scholar]
  74. Allemann I.B. Baumann L. Botanicals in skin care products. Int. J. Dermatol. 2009 48 9 923 934 10.1111/j.1365‑4632.2009.04081.x 19702974
    [Google Scholar]
  75. Sharma B. Sharma A. Future prospect of nanotechnology in development of anti-ageing formulations. Int. J. Pharm. Pharm. Sci. 2012 4 57 66
    [Google Scholar]
  76. Graf J. Anti-aging skin care ingredient technologies. Cosmetic Dermatology. Springer Berlin Heidelberg 2005 17 28 10.1007/3‑540‑27333‑6_2
    [Google Scholar]
  77. Lazarus M.C. Baumann L.S. The use of cosmeceutical moisturizers. Dermatol. Ther. 2001 14 3 200 207 10.1046/j.1529‑8019.2001.01030.x
    [Google Scholar]
  78. Sorg O. Kuenzli S. Kaya G. Saurat J.H. Proposed mechanisms of action for retinoid derivatives in the treatment of skin aging. J. Cosmet. Dermatol. 2005 4 4 237 244 10.1111/j.1473‑2165.2005.00198.x 17168870
    [Google Scholar]
  79. Gondikas A.P. Kammer F. Reed R.B. Wagner S. Ranville J.F. Hofmann T. Release of TiO2 nanoparticles from sunscreens into surface waters: A one-year survey at the old Danube recreational Lake. Environ. Sci. Technol. 2014 48 10 5415 5422 10.1021/es405596y 24689731
    [Google Scholar]
  80. Gupta M. Agrawal U. Vyas S.P. Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opin. Drug Deliv. 2012 9 7 783 804 10.1517/17425247.2012.686490 22559240
    [Google Scholar]
  81. Gung S. New formulation strategies in topical antifungal therapy. JCDSA 2013 3 1 56 65 10.4236/jcdsa.2013.31A009
    [Google Scholar]
  82. Barry B.W. Penetration enhancers. In: Skin Pharmacokinetics. Basel Karger 1987 121 127
    [Google Scholar]
  83. Nacht S. Katz M. The microsponge: A novel topical programmable delivery system. Drugs Pharm Sci 1990 42 299 325
    [Google Scholar]
  84. Pradhan S.K. Microsponges as the versatile tool for drug delivery system. Int. J. Res. Pharm. Chem. 2011 1 2 243 258
    [Google Scholar]
  85. Prahl S. Kueper T. Biernoth T. Aging skin is functionally anaerobic: Importance of coenzyme Q 10 for anti aging skin care. Biofactors 2008 32 1-4 245 255 10.1002/biof.5520320129 19096122
    [Google Scholar]
  86. Angerhofer C.K. Maes D. Giacomoni P.U. The use of natural compounds and botanicals in the development of anti-aging skin care products. In: Skin Aging Handbook. William Andrew Publishing 2009 205 263 10.1016/B978‑0‑8155‑1584‑5.50014‑4
    [Google Scholar]
  87. Morganti P. Use and potential of nanotechnology in cosmetic dermatology. Clin. Cosmet. Investig. Dermatol. 2010 3 5 13 10.2147/CCID.S4506 21437055
    [Google Scholar]
  88. Rahimpour Y. Hamishehkar H. Liposomes in cosmeceutics. Expert Opin. Drug Deliv. 2012 9 4 443 455 10.1517/17425247.2012.666968 22413847
    [Google Scholar]
  89. Jaspart S. Piel G. Delattre L. Evrard B. Solid lipid microparticles: Formulation, preparation, characterisation, drug release and applications. Expert Opin. Drug Deliv. 2005 2 1 75 87 10.1517/17425247.2.1.75 16296736
    [Google Scholar]
  90. Kaur I. Agrawal R. Nanotechnology: A new paradigm in cosmeceuticals. Recent Pat. Drug Deliv. Formul. 2007 1 2 171 182 10.2174/187221107780831888 19075884
    [Google Scholar]
  91. Yang D. Pornpattananangkul D. Nakatsuji T. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials 2009 30 30 6035 6040 10.1016/j.biomaterials.2009.07.033 19665786
    [Google Scholar]
  92. Tao L. Skin delivery from lipid vesicles. Cosmet Toiletries 2000 115 4 43 50
    [Google Scholar]
  93. Touitou E. Dayan N. Bergelson L. Godin B. Eliaz M. Ethosomes — novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. J. Control. Release 2000 65 3 403 418 10.1016/S0168‑3659(99)00222‑9 10699298
    [Google Scholar]
  94. Sinico C. Fadda A.M. Vesicular carriers for dermal drug delivery. Expert Opin. Drug Deliv. 2009 6 8 813 825 10.1517/17425240903071029 19569979
    [Google Scholar]
  95. Guimarães K.L. Ré M.I. Lipid Nanoparticles as Carriers for Cosmetic Ingredients: The First (SLN) and the Second Generation (NLC). In: Nanocosmetics and Nanomedicines. Research Gate 2011 101 22 10.1007/978‑3‑642‑19792‑5_5
    [Google Scholar]
  96. Muller R.H. Colloidal carriers for controlled drug delivery and targeting: Modification, characterization and in vivo distribution. CRC Press 1991
    [Google Scholar]
  97. Müller RH Radtke M Wissing SA Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002 54 S1 S131 55 (Suppl. 1) 10.1016/S0169‑409X(02)00118‑7 12460720
    [Google Scholar]
  98. Müller R. Petersen R. Hommoss A. Pardeike J. Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv. Drug Deliv. Rev. 2007 59 6 522 530 10.1016/j.addr.2007.04.012 17602783
    [Google Scholar]
  99. Guterres S.S. Alves M.P. Pohlmann A.R. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights 2007 2 1 147 157 10.1177/117739280700200002 21901071
    [Google Scholar]
  100. Shakeel F. Shafiq S. Haq N. Alanazi F.K. Alsarra I.A. Nanoemulsions as potential vehicles for transdermal and dermal delivery of hydrophobic compounds: An overview. Expert Opin. Drug Deliv. 2012 9 8 953 974 10.1517/17425247.2012.696605 22703228
    [Google Scholar]
  101. Makrantonaki E. Zouboulis C.C. Molecular mechanisms of skin aging: State of the art. Ann. N. Y. Acad. Sci. 2007 1119 1 40 50 10.1196/annals.1404.027 18056953
    [Google Scholar]
  102. Ahmed I.A. Mikail M.A. Zamakshshari N.H. Mustafa M.R. Hashim N.M. Othman R. Trends and challenges in phytotherapy and phytocosmetics for skin aging. Saudi J. Biol. Sci. 2022 29 8 103363 10.1016/j.sjbs.2022.103363 35813113
    [Google Scholar]
  103. Yadav N.K. Nanda S. Sharma G. Katare O.P. Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: Characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation. J. Drug Target. 2016 24 3 257 271 10.3109/1061186X.2015.1077845 26302815
    [Google Scholar]
  104. Yue Y. Zhou H. Liu G. Li Y. Yan Z. Duan M. The advantages of a novel CoQ10 delivery system in skin photo-protection. Int. J. Pharm. 2010 392 1-2 57 63 10.1016/j.ijpharm.2010.03.032 20302925
    [Google Scholar]
  105. Schwarz J.C. Baisaeng N. Hoppel M. Löw M. Keck C.M. Valenta C. Ultra-small NLC for improved dermal delivery of coenyzme Q10. Int. J. Pharm. 2013 447 1-2 213 217 10.1016/j.ijpharm.2013.02.037 23438979
    [Google Scholar]
  106. Kaur C.D. Saraf S. Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin. J. Cosmet. Dermatol. 2011 10 4 260 265 10.1111/j.1473‑2165.2011.00586.x 22151933
    [Google Scholar]
  107. Gupta N.K. Dixit V.K. Development and evaluation of vesicular system for curcumin delivery. Arch. Dermatol. Res. 2011 303 2 89 101 10.1007/s00403‑010‑1096‑6 21085975
    [Google Scholar]
  108. Friedrich R.B. Kann B. Coradini K. Offerhaus H.L. Beck R.C.R. Windbergs M. Skin penetration behavior of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin. Eur. J. Pharm. Sci. 2015 78 204 213 10.1016/j.ejps.2015.07.018 26215463
    [Google Scholar]
  109. Kahraman E. ÿzhan G, ÿzsoy Y, Güngör S. Polymeric micellar nanocarriers of benzoyl peroxide as potential follicular targeting approach for acne treatment. Colloids Surf. B Biointerfaces 2016 146 692 699 10.1016/j.colsurfb.2016.07.029 27434156
    [Google Scholar]
  110. Strnadova K. Sandera V. Dvorankova B. Skin aging: The dermal perspective. Clin. Dermatol. 2019 37 4 326 335 10.1016/j.clindermatol.2019.04.005 31345320
    [Google Scholar]
  111. Jan H. Shah M. Andleeb A. Plant‐based synthesis of zinc oxide nanoparticles (ZnO‐NPs) using aqueous leaf extract of Aquilegia pubiflora: Their antiproliferative activity against hepg2 cells inducing reactive oxygen species and other in vitro properties. Oxid. Med. Cell. Longev. 2021 2021 1 4786227 10.1155/2021/4786227 34457112
    [Google Scholar]
  112. Sherif S. Bendas E.R. Badawy S. The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. Eur. J. Pharm. Biopharm. 2014 86 2 251 259 10.1016/j.ejpb.2013.09.008 24056055
    [Google Scholar]
  113. Goindi S. Guleria A. Aggarwal N. Development and evaluation of solid lipid nanoparticles of N-6-furfuryl adenine for prevention of photoaging. J. Biomed. Nanotechnol. 2015 11 10 1734 1746 10.1166/jbn.2015.2111 26502637
    [Google Scholar]
  114. Manosroi A. Chutoprapat R. Abe M. Manosroi W. Manosroi J. Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. Pharm. Biol. 2012 50 2 208 224 10.3109/13880209.2011.596206 22235888
    [Google Scholar]
  115. Bilal M. Iqbal H.M.N. An insight into toxicity and human-health-related adverse consequences of cosmeceuticals — A review. Sci. Total Environ. 2019 670 555 568 10.1016/j.scitotenv.2019.03.261 30909033
    [Google Scholar]
/content/journals/cas/10.2174/0118746098384581250904035955
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Nanotechnology-Based Approaches for Combating Skin Aging: A Comprehensive Review
Bentham Science Publishers ; https://doi.org/10.2174/0118746098384581250904035955
/content/journals/cas/10.2174/0118746098384581250904035955
/content/journals/cas/10.2174/0118746098384581250904035955
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  • Article Type:     Review Article
Keywords: nanocarriers ; skin aging ; anti-aging ; vesicles ; antioxidants ; Nanotechnology

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