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2000
Volume 22, Issue 11
  • ISSN: 1567-2050
  • E-ISSN: 1875-5828

Abstract

Artificial intelligence (AI) refers to a system that can simulate and execute the processes of human thinking and learning, and make informed decisions. Fueled by the development of AI, the quality and effectiveness of medical work have gained momentum. AI technology plays an increasingly important role in healthcare, exhibiting substantial potential in clinical practice and decision-making processes. In Alzheimer’s disease (AD), where early diagnosis and treatment remain challenging due to clinical heterogeneity and insidious progression, AI could offer excellent solutions. AI models can integrate multi-modal data to identify pre-symptomatic biomarkers and stratify high-risk cohorts, improving diagnostic accuracy, assisting with personalizing treatment and care. Furthermore, AI can accelerate drug discovery and development through drug-target identification and predictive modeling of compound efficacy. However, data quality, supervision, transparency, privacy, and ethical concerns need to be addressed. By identifying and retrieving studies for the systematic review, this article provides a comprehensive overview of current progress and related AI applications in AD.

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2025-10-22
2026-01-03
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References

  1. ZhengQ. WangX. Alzheimer’s disease: Insights into pathology, molecular mechanisms, and therapy.Protein Cell20251628312010.1093/procel/pwae02638733347
    [Google Scholar]
  2. FangM. HuJ. WeissJ. KnopmanD.S. AlbertM. WindhamB.G. WalkerK.A. SharrettA.R. GottesmanR.F. LutseyP.L. MosleyT. SelvinE. CoreshJ. Lifetime risk and projected burden of dementia.Nat. Med.202531377277610.1038/s41591‑024‑03340‑939806070
    [Google Scholar]
  3. Gaugler, J.; James, B.; Johnson, T.; Raimer, J.; Solis, M.; Weuve, J.; Buckley, R.F.; Hohman, T.J. 2022 Alzheimer’s disease facts and figures.Alzheimers Dement.202218470078910.1002/alz.1263835289055
    [Google Scholar]
  4. Ahmadi-AbhariS. BrayneC. Descriptive epidemiology of dementia in the US.BMJ2025389r88810.1136/bmj.r88840393744
    [Google Scholar]
  5. LiX. FengX. SunX. HouN. HanF. LiuY. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2019.Front. Aging Neurosci.20221493748610.3389/fnagi.2022.93748636299608
    [Google Scholar]
  6. GutiérrezI.L. Dello RussoC. NovellinoF. CasoJ.R. García-BuenoB. LezaJ.C. MadrigalJ.L.M. Noradrenaline in Alzheimer’s Disease: A new potential therapeutic target.Int. J. Mol. Sci.20222311614310.3390/ijms2311614335682822
    [Google Scholar]
  7. JackC.R.Jr BennettD.A. BlennowK. CarrilloM.C. DunnB. HaeberleinS.B. HoltzmanD.M. JagustW. JessenF. KarlawishJ. LiuE. MolinuevoJ.L. MontineT. PhelpsC. RankinK.P. RoweC.C. ScheltensP. SiemersE. SnyderH.M. SperlingR. ElliottC. MasliahE. RyanL. SilverbergN. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease.Alzheimers Dement.201814453556210.1016/j.jalz.2018.02.01829653606
    [Google Scholar]
  8. ScheltensP. De StrooperB. KivipeltoM. HolstegeH. ChételatG. TeunissenC.E. CummingsJ. van der FlierW.M. Alzheimer’s disease.Lancet2021397102841577159010.1016/S0140‑6736(20)32205‑433667416
    [Google Scholar]
  9. BrigantiG. Le MoineO. Artificial intelligence in medicine: Today and tomorrow.Front. Med.202072710.3389/fmed.2020.0002732118012
    [Google Scholar]
  10. EricksonB.J. Basic artificial intelligence techniques: Machine learning and deep learning.Radiol. Clin. North Am.202159693394010.1016/j.rcl.2021.06.00434689878
    [Google Scholar]
  11. SilverD. SchrittwieserJ. SimonyanK. AntonoglouI. HuangA. GuezA. HubertT. BakerL. LaiM. BoltonA. ChenY. LillicrapT. HuiF. SifreL. van den DriesscheG. GraepelT. HassabisD. Mastering the game of Go without human knowledge.Nature2017550767635435910.1038/nature2427029052630
    [Google Scholar]
  12. MullardA. What does AlphaFold mean for drug discovery?Nat. Rev. Drug Discov.2021201072572710.1038/d41573‑021‑00161‑034522032
    [Google Scholar]
  13. KovoorJ.G. GuptaA.K. BacchiS. ChatGPT: Effective writing is succinct.BMJ2023381p112510.1136/bmj.p112537220943
    [Google Scholar]
  14. SmithJ. Daily briefing: The pros and cons of DeepSeek.Nature2025[Epub ahead of Print]10.1038/d41586‑025‑00330‑w39890911
    [Google Scholar]
  15. Barragán-MonteroA. JavaidU. ValdésG. NguyenD. DesbordesP. MacqB. WillemsS. VandewinckeleL. HolmströmM. LöfmanF. MichielsS. SourisK. SterpinE. LeeJ.A. Artificial intelligence and machine learning for medical imaging: A technology review.Phys. Med.20218324225610.1016/j.ejmp.2021.04.01633979715
    [Google Scholar]
  16. ChoiR.Y. CoynerA.S. Kalpathy-CramerJ. ChiangM.F. CampbellJ.P. Introduction to machine learning, neural networks, and deep learning.Transl. Vis. Sci. Technol.2020921410.1167/tvst.9.2.1432704420
    [Google Scholar]
  17. Kalpathy-CramerJ. PatelJ.B. BridgeC. ChangK. Basic artificial intelligence techniques: Evaluation of artificial intelligence performance.Radiol. Clin. North Am.202159694195410.1016/j.rcl.2021.06.00534689879
    [Google Scholar]
  18. AttiaZ.I. KapaS. Lopez-JimenezF. McKieP.M. LadewigD.J. SatamG. PellikkaP.A. Enriquez-SaranoM. NoseworthyP.A. MungerT.M. AsirvathamS.J. ScottC.G. CarterR.E. FriedmanP.A. Screening for cardiac contractile dysfunction using an artificial intelligence–enabled electrocardiogram.Nat. Med.2019251707410.1038/s41591‑018‑0240‑230617318
    [Google Scholar]
  19. de GreyA.D.N.J. Artificial intelligence and medical research: Time to aim higher?Rejuvenation Res.201619210510610.1089/rej.2016.182726993572
    [Google Scholar]
  20. PatelM.R. BaluS. PencinaM.J. Translating AI for the clinician.JAMA2024332201701170210.1001/jama.2024.2177239405321
    [Google Scholar]
  21. SchorN.F. Equipping AI for unbiased and inclusive neurology.JAMA Neurol.2025823211–21210.1001/jamaneurol.2024.395439585712
    [Google Scholar]
  22. HametP. TremblayJ. Artificial intelligence in medicine.Metabolism201769S36S4010.1016/j.metabol.2017.01.01128126242
    [Google Scholar]
  23. LeCunY. BengioY. HintonG. Deep learning.Nature2015521755343644410.1038/nature1453926017442
    [Google Scholar]
  24. DorseyE.R. PapapetropoulosS. XiongM. KieburtzK. The first frontier: Digital biomarkers for neurodegenerative disorders.Digit. Biomark.20171161310.1159/00047738332095743
    [Google Scholar]
  25. PiauA. WildK. MattekN. KayeJ. Current state of digital biomarker technologies for real-life, home-based monitoring of cognitive function for mild cognitive impairment to mild Alzheimer disease and implications for clinical care: Systematic review.J. Med. Internet Res.2019218e1278510.2196/1278531471958
    [Google Scholar]
  26. VasudevanS. SahaA. TarverM.E. PatelB. Digital biomarkers: Convergence of digital health technologies and biomarkers.NPJ Digit. Med.2022513610.1038/s41746‑022‑00583‑z35338234
    [Google Scholar]
  27. GaoX.R. ChiariglioneM. QinK. NuytemansK. ScharreD.W. LiY.J. MartinE.R. Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer’s disease prediction.Sci. Rep.202313145010.1038/s41598‑023‑27551‑136624143
    [Google Scholar]
  28. AllenB. AgarwalS. CoombsL. WaldC. DreyerK. 2020 ACR data science institute artificial intelligence survey.J. Am. Coll. Radiol.20211881153115910.1016/j.jacr.2021.04.00233891859
    [Google Scholar]
  29. LiL. XuW. TanC.C. CaoX.P. WeiB.Z. DongC.W. TanL. A gene-environment interplay between omega-3 supplementation and APOE ε4 provides insights for Alzheimer’s disease precise prevention amongst high-genetic-risk population.Eur. J. Neurol.202229242243110.1111/ene.1516034710256
    [Google Scholar]
  30. LivingstonG. HuntleyJ. LiuK.Y. CostafredaS.G. SelbækG. AlladiS. AmesD. BanerjeeS. BurnsA. BrayneC. FoxN.C. FerriC.P. GitlinL.N. HowardR. KalesH.C. KivimäkiM. LarsonE.B. NakasujjaN. RockwoodK. SamusQ. ShiraiK. Singh-ManouxA. SchneiderL.S. WalshS. YaoY. SommerladA. MukadamN. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.Lancet20244041045257262810.1016/S0140‑6736(24)01296‑039096926
    [Google Scholar]
  31. LongJ.M. HoltzmanD.M. Alzheimer disease: An update on pathobiology and treatment strategies.Cell2019179231233910.1016/j.cell.2019.09.00131564456
    [Google Scholar]
  32. ZhangJ. ZhangY. WangJ. XiaY. ZhangJ. ChenL. Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies.Signal Transduct. Target. Ther.20249121110.1038/s41392‑024‑01911‑339174535
    [Google Scholar]
  33. KunkleB.W. Grenier-BoleyB. SimsR. BisJ.C. DamotteV. NajA.C. BolandA. VronskayaM. van der LeeS.J. Amlie-WolfA. BellenguezC. FrizattiA. ChourakiV. MartinE.R. SleegersK. BadarinarayanN. JakobsdottirJ. Hamilton-NelsonK.L. Moreno-GrauS. OlasoR. RaybouldR. ChenY. KuzmaA.B. HiltunenM. MorganT. AhmadS. VardarajanB.N. EpelbaumJ. HoffmannP. BoadaM. BeechamG.W. GarnierJ.G. HaroldD. FitzpatrickA.L. ValladaresO. MoutetM.L. GerrishA. SmithA.V. QuL. BacqD. DenningN. JianX. ZhaoY. Del ZompoM. FoxN.C. ChoiS.H. MateoI. HughesJ.T. AdamsH.H. MalamonJ. Sanchez-GarciaF. PatelY. BrodyJ.A. DombroskiB.A. NaranjoM.C.D. DaniilidouM. EiriksdottirG. MukherjeeS. WallonD. UphillJ. AspelundT. CantwellL.B. GarziaF. GalimbertiD. HoferE. ButkiewiczM. FinB. ScarpiniE. SarnowskiC. BushW.S. MeslageS. KornhuberJ. WhiteC.C. SongY. BarberR.C. EngelborghsS. SordonS. VoijnovicD. AdamsP.M. VandenbergheR. MayhausM. CupplesL.A. AlbertM.S. De DeynP.P. GuW. HimaliJ.J. BeeklyD. SquassinaA. HartmannA.M. OrellanaA. BlackerD. Rodriguez-RodriguezE. LovestoneS. GarciaM.E. DoodyR.S. Munoz-FernadezC. SussamsR. LinH. FairchildT.J. BenitoY.A. HolmesC. Karamujić-ČomićH. FroschM.P. ThonbergH. MaierW. RoshchupkinG. GhettiB. GiedraitisV. KawaliaA. LiS. HuebingerR.M. KilanderL. MoebusS. HernándezI. KambohM.I. BrundinR. TurtonJ. YangQ. KatzM.J. ConcariL. LordJ. BeiserA.S. KeeneC.D. HelisalmiS. KloszewskaI. KukullW.A. KoivistoA.M. LynchA. TarragaL. LarsonE.B. HaapasaloA. LawlorB. MosleyT.H. LiptonR.B. SolfrizziV. GillM. LongstrethW.T.Jr MontineT.J. FrisardiV. Diez-FairenM. RivadeneiraF. PetersenR.C. DeramecourtV. AlvarezI. SalaniF. CiaramellaA. BoerwinkleE. ReimanE.M. FievetN. RotterJ.I. ReischJ.S. HanonO. CupidiC. Andre UitterlindenA.G. RoyallD.R. DufouilC. MalettaR.G. de RojasI. SanoM. BriceA. CecchettiR. George-HyslopP.S. RitchieK. TsolakiM. TsuangD.W. DuboisB. CraigD. WuC.K. SoininenH. AvramidouD. AlbinR.L. FratiglioniL. GermanouA. ApostolovaL.G. KellerL. KoutroumaniM. ArnoldS.E. PanzaF. GkatzimaO. AsthanaS. HannequinD. WhiteheadP. AtwoodC.S. CaffarraP. HampelH. QuintelaI. CarracedoÁ. LannfeltL. RubinszteinD.C. BarnesL.L. PasquierF. FrölichL. BarralS. McGuinnessB. BeachT.G. JohnstonJ.A. BeckerJ.T. PassmoreP. BigioE.H. SchottJ.M. BirdT.D. WarrenJ.D. BoeveB.F. LuptonM.K. BowenJ.D. ProitsiP. BoxerA. PowellJ.F. BurkeJ.R. KauweJ.S.K. BurnsJ.M. MancusoM. BuxbaumJ.D. BonuccelliU. CairnsN.J. McQuillinA. CaoC. LivingstonG. CarlsonC.S. BassN.J. CarlssonC.M. HardyJ. CarneyR.M. BrasJ. CarrasquilloM.M. GuerreiroR. AllenM. ChuiH.C. FisherE. MasulloC. CroccoE.A. DeCarliC. BisceglioG. DickM. MaL. DuaraR. Graff-RadfordN.R. EvansD.A. HodgesA. FaberK.M. SchererM. FallonK.B. RiemenschneiderM. FardoD.W. HeunR. FarlowM.R. KölschH. FerrisS. LeberM. ForoudT.M. HeuserI. GalaskoD.R. GieglingI. GearingM. HüllM. GeschwindD.H. GilbertJ.R. MorrisJ. GreenR.C. MayoK. GrowdonJ.H. FeulnerT. HamiltonR.L. HarrellL.E. DrichelD. HonigL.S. CushionT.D. HuentelmanM.J. HollingworthP. HuletteC.M. HymanB.T. MarshallR. JarvikG.P. MeggyA. AbnerE. MenziesG.E. JinL.W. LeonenkoG. RealL.M. JunG.R. BaldwinC.T. GrozevaD. KarydasA. RussoG. KayeJ.A. KimR. JessenF. KowallN.W. VellasB. KramerJ.H. VardyE. LaFerlaF.M. JöckelK.H. LahJ.J. DichgansM. LeverenzJ.B. MannD. LeveyA.I. Pickering-BrownS. LiebermanA.P. KloppN. LunettaK.L. WichmannH.E. LyketsosC.G. MorganK. MarsonD.C. BrownK. MartiniukF. MedwayC. MashD.C. NöthenM.M. MasliahE. HooperN.M. McCormickW.C. DanieleA. McCurryS.M. BayerA. McDavidA.N. GallacherJ. McKeeA.C. van den BusscheH. MesulamM. BrayneC. MillerB.L. Riedel-HellerS. MillerC.A. MillerJ.W. Al-ChalabiA. MorrisJ.C. ShawC.E. MyersA.J. WiltfangJ. O’BryantS. OlichneyJ.M. AlvarezV. ParisiJ.E. SingletonA.B. PaulsonH.L. CollingeJ. PerryW.R. MeadS. PeskindE. CribbsD.H. RossorM. PierceA. RyanN.S. PoonW.W. NacmiasB. PotterH. SorbiS. QuinnJ.F. SacchinelliE. RajA. SpallettaG. RaskindM. CaltagironeC. BossùP. OrfeiM.D. ReisbergB. ClarkeR. ReitzC. SmithA.D. RingmanJ.M. WardenD. RobersonE.D. WilcockG. RogaevaE. BruniA.C. RosenH.J. GalloM. RosenbergR.N. Ben-ShlomoY. SagerM.A. MecocciP. SaykinA.J. PastorP. CuccaroM.L. VanceJ.M. SchneiderJ.A. SchneiderL.S. SliferS. SeeleyW.W. SmithA.G. SonnenJ.A. SpinaS. SternR.A. SwerdlowR.H. TangM. TanziR.E. TrojanowskiJ.Q. TroncosoJ.C. Van DeerlinV.M. Van EldikL.J. VintersH.V. VonsattelJ.P. WeintraubS. Welsh-BohmerK.A. WilhelmsenK.C. WilliamsonJ. WingoT.S. WoltjerR.L. WrightC.B. YuC.E. YuL. SabaY. PilottoA. BullidoM.J. PetersO. CraneP.K. BennettD. BoscoP. CotoE. BoccardiV. De JagerP.L. LleoA. WarnerN. LopezO.L. IngelssonM. DeloukasP. CruchagaC. GraffC. GwilliamR. FornageM. GoateA.M. Sanchez-JuanP. KehoeP.G. AminN. Ertekin-TanerN. BerrC. DebetteS. LoveS. LaunerL.J. YounkinS.G. DartiguesJ.F. CorcoranC. IkramM.A. DicksonD.W. NicolasG. CampionD. TschanzJ. SchmidtH. HakonarsonH. ClarimonJ. MungerR. SchmidtR. FarrerL.A. Van BroeckhovenC. C O’DonovanM. DeStefanoA.L. JonesL. HainesJ.L. DeleuzeJ.F. OwenM.J. GudnasonV. MayeuxR. Escott-PriceV. PsatyB.M. RamirezA. WangL.S. RuizA. van DuijnC.M. HolmansP.A. SeshadriS. WilliamsJ. AmouyelP. SchellenbergG.D. LambertJ.C. Pericak-VanceM.A. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat. Genet.201951341443010.1038/s41588‑019‑0358‑230820047
    [Google Scholar]
  34. BellenguezC. KüçükaliF. JansenI.E. KleineidamL. Moreno-GrauS. AminN. NajA.C. Campos-MartinR. Grenier-BoleyB. AndradeV. HolmansP.A. BolandA. DamotteV. van der LeeS.J. CostaM.R. KuulasmaaT. YangQ. de RojasI. BisJ.C. YaqubA. ProkicI. ChapuisJ. AhmadS. GiedraitisV. AarslandD. Garcia-GonzalezP. AbdelnourC. Alarcón-MartínE. AlcoleaD. AlegretM. AlvarezI. ÁlvarezV. ArmstrongN.J. TsolakiA. AntúnezC. AppollonioI. ArcaroM. ArchettiS. PastorA.A. ArosioB. AthanasiuL. BaillyH. BanajN. BaqueroM. BarralS. BeiserA. PastorA.B. BelowJ.E. BenchekP. BenussiL. BerrC. BesseC. BessiV. BinettiG. BizarroA. BlesaR. BoadaM. BoerwinkleE. BorroniB. BoschiS. BossùP. BråthenG. BresslerJ. BresnerC. BrodatyH. BrookesK.J. BruscoL.I. Buiza-RuedaD. BûrgerK. BurholtV. BushW.S. CaleroM. CantwellL.B. CheneG. ChungJ. CuccaroM.L. CarracedoÁ. CecchettiR. Cervera-CarlesL. CharbonnierC. ChenH.H. ChillottiC. CicconeS. ClaassenJ.A.H.R. ClarkC. ContiE. Corma-GómezA. CostantiniE. CustoderoC. DaianD. DalmassoM.C. DanieleA. DardiotisE. DartiguesJ.F. de DeynP.P. de Paiva LopesK. de WitteL.D. DebetteS. DeckertJ. del SerT. DenningN. DeStefanoA. DichgansM. Diehl-SchmidJ. Diez-FairenM. RossiP.D. DjurovicS. DuronE. DüzelE. DufouilC. EiriksdottirG. EngelborghsS. Escott-PriceV. EspinosaA. EwersM. FaberK.M. FabrizioT. NielsenS.F. FardoD.W. FarottiL. FenoglioC. Fernández-FuertesM. FerrariR. FerreiraC.B. FerriE. FinB. FischerP. FladbyT. FließbachK. FongangB. FornageM. ForteaJ. ForoudT.M. FostinelliS. FoxN.C. Franco-MacíasE. BullidoM.J. Frank-GarcíaA. FroelichL. Fulton-HowardB. GalimbertiD. García-AlbercaJ.M. García-GonzálezP. Garcia-MadronaS. Garcia-RibasG. GhidoniR. GieglingI. GiorgioG. GoateA.M. GoldhardtO. Gomez-FonsecaD. González-PérezA. GraffC. GrandeG. GreenE. GrimmerT. GrünblattE. GruninM. GudnasonV. Guetta-BaranesT. HaapasaloA. HadjigeorgiouG. HainesJ.L. Hamilton-NelsonK.L. HampelH. HanonO. HardyJ. HartmannA.M. HausnerL. HarwoodJ. Heilmann-HeimbachS. HelisalmiS. HenekaM.T. HernándezI. HerrmannM.J. HoffmannP. HolmesC. HolstegeH. VilasR.H. HulsmanM. HumphreyJ. BiesselsG.J. JianX. JohanssonC. JunG.R. KastumataY. KauweJ. KehoeP.G. KilanderL. StåhlbomA.K. KivipeltoM. KoivistoA. KornhuberJ. KosmidisM.H. KukullW.A. KuksaP.P. KunkleB.W. KuzmaA.B. LageC. LaukkaE.J. LaunerL. LauriaA. LeeC.Y. LehtisaloJ. LerchO. LleóA. LongstrethW.Jr LopezO. de MunainA.L. LoveS. LöwemarkM. LuckcuckL. LunettaK.L. MaY. MacíasJ. MacLeodC.A. MaierW. MangialascheF. SpallazziM. MarquiéM. MarshallR. MartinE.R. MontesA.M. RodríguezC.M. MasulloC. MayeuxR. MeadS. MecocciP. MedinaM. MeggyA. MehrabianS. MendozaS. Menéndez-GonzálezM. MirP. MoebusS. MolM. Molina-PorcelL. MontrrealL. MorelliL. MorenoF. MorganK. MosleyT. NöthenM.M. MuchnikC. MukherjeeS. NacmiasB. NganduT. NicolasG. NordestgaardB.G. OlasoR. OrellanaA. OrsiniM. OrtegaG. PadovaniA. PaoloC. PapenbergG. ParnettiL. PasquierF. PastorP. PelosoG. Pérez-CordónA. Pérez-TurJ. PericardP. PetersO. PijnenburgY.A.L. PinedaJ.A. Piñol-RipollG. PisanuC. PolakT. PoppJ. PosthumaD. PrillerJ. PuertaR. QuenezO. QuintelaI. ThomassenJ.Q. RábanoA. RaineroI. RajabliF. RamakersI. RealL.M. ReindersM.J.T. ReitzC. Reyes-DumeyerD. RidgeP. Riedel-HellerS. RiedererP. RobertoN. Rodriguez-RodriguezE. RongveA. AllendeI.R. Rosende-RocaM. RoyoJ.L. RubinoE. RujescuD. SáezM.E. SakkaP. SaltvedtI. SanabriaÁ. Sánchez-ArjonaM.B. Sanchez-GarciaF. JuanP.S. Sánchez-ValleR. SandoS.B. SarnowskiC. SatizabalC.L. ScamosciM. ScarmeasN. ScarpiniE. ScheltensP. ScherbaumN. SchererM. SchmidM. SchneiderA. SchottJ.M. SelbækG. SeripaD. SerranoM. ShaJ. ShadrinA.A. SkrobotO. SliferS. SnijdersG.J.L. SoininenH. SolfrizziV. SolomonA. SongY. SorbiS. Sotolongo-GrauO. SpallettaG. SpottkeA. SquassinaA. StordalE. TartanJ.P. TárragaL. TesíN. ThalamuthuA. ThomasT. TostoG. TraykovL. TremolizzoL. Tybjærg-HansenA. UitterlindenA. UllgrenA. UlsteinI. ValeroS. ValladaresO. BroeckhovenC.V. VanceJ. VardarajanB.N. van der LugtA. DongenJ.V. van RooijJ. van SwietenJ. VandenbergheR. VerheyF. VidalJ.S. VogelgsangJ. VyhnalekM. WagnerM. WallonD. WangL.S. WangR. WeinholdL. WiltfangJ. WindleG. WoodsB. YannakouliaM. ZareH. ZhaoY. ZhangX. ZhuC. ZulaicaM. LaczoJ. MatoskaV. SerpenteM. AssognaF. PirasF. PirasF. CiulloV. ShofanyJ. FerrareseC. AndreoniS. SalaG. ZoiaC.P. ZompoM.D. BenussiA. BastianiP. TakaloM. NatunenT. LaatikainenT. TuomilehtoJ. AntikainenR. StrandbergT. LindströmJ. PeltonenM. AbrahamR. Al-ChalabiA. BassN.J. BrayneC. BrownK.S. CollingeJ. CraigD. DeloukasP. FoxN. GerrishA. GillM. GwilliamR. HaroldD. HollingworthP. JohnstonJ.A. JonesL. LawlorB. LivingstonG. LovestoneS. LuptonM. LynchA. MannD. McGuinnessB. McQuillinA. O’DonovanM.C. OwenM.J. PassmoreP. PowellJ.F. ProitsiP. RossorM. ShawC.E. SmithA.D. GurlingH. ToddS. MummeryC. RyanN. LacidognaG. Adarmes-GómezA. MauleónA. PanchoA. GailhajenetA. LafuenteA. Macias-GarcíaD. MartínE. PelejàE. CarrilloF. MerlínI.S. Garrote-EspinaL. VargasL. Carrion-ClaroM. MarínM. LabradorM. BuendiaM. AlonsoM.D. GuitartM. MorenoM. IbarriaM. PeriñánM. AguileraN. Gómez-GarreP. CañabateP. EscuelaR. Pineda-SánchezR. Vigo-OrtegaR. JesúsS. PrecklerS. Rodrigo-HerreroS. DiegoS. VaccaA. RovetaF. SalvadoriN. ChipiE. BoeckerH. LaskeC. PerneczkyR. AnastasiouC. JanowitzD. MalikR. AnastasiouA. ParveenK. LageC. López-GarcíaS. AntonellA. MihovaK.Y. BelezhanskaD. WeberH. KochenS. SolisP. MedelN. LissoJ. SevillanoZ. PolitisD.G. CoresV. CuestaC. OrtizC. BachaJ.I. RiosM. SaenzA. AbalosM.S. KohlerE. PalacioD.L. EtcheparebordaI. KohlerM. NovackG. PrestiaF.A. GaleanoP. CastañoE.M. GermaniS. TosoC.R. RojoM. InginoC. MangoneC. RubinszteinD.C. TeipelS. FievetN. DeramerourtV. ForsellC. ThonbergH. BjerkeM. RoeckE.D. Martínez-LarradM.T. OlivarN. AguileraN. CanoA. CañabateP. MaciasJ. MaroñasO. Nuñez-LlavesR. OlivéC. PelejáE. Adarmes-GómezA.D. AlonsoM.D. Amer-FerrerG. AntequeraM. BurgueraJ.A. CarrilloF. Carrión-ClaroM. CasajerosM.J. Martinez de PancorboM. EscuelaR. Garrote-EspinaL. Gómez-GarreP. HevillaS. JesúsS. EspinosaM.A.L. LegazA. López-GarcíaS. Macias-GarcíaD. ManzanaresS. MarínM. Marín-MuñozJ. MarínT. MartínezB. MartínezV. Martínez-Lage ÁlvarezP. IriarteM.M. Periñán-TocinoM.T. Pineda-SánchezR. Real de AsúaD. RodrigoS. SastreI. VicenteM.P. Vigo-OrtegaR. VivancosL. EpelbaumJ. HannequinD. campionD. DeramecourtV. TzourioC. BriceA. DuboisB. WilliamsA. ThomasC. DaviesC. NashW. DowzellK. MoralesA.C. Bernardo-HarringtonM. TurtonJ. LordJ. BrownK. VardyE. FisherE. WarrenJ.D. RossorM. RyanN.S. GuerreiroR. UphillJ. BassN. HeunR. KölschH. SchürmannB. LacourA. HeroldC. JohnstonJ.A. PassmoreP. PowellJ. PatelY. HodgesA. BeckerT. WardenD. WilcockG. ClarkeR. DeloukasP. Ben-ShlomoY. HooperN.M. Pickering-BrownS. SussamsR. WarnerN. BayerA. HeuserI. DrichelD. KloppN. MayhausM. RiemenschneiderM. PinchlerS. FeulnerT. GuW. van den BusscheH. HüllM. FrölichL. WichmannH-E. JöckelK-H. O’DonovanM. OwenM. BahramiS. BosnesI. SelnesP. BerghS. PalotieA. DalyM. JacobH. MatakidouA. RunzH. JohnS. PlengeR. McCarthyM. HunkapillerJ. EhmM. WaterworthD. FoxC. MalarstigA. KlingerK. CallK. BehrensT. LoerchP. MäkeläT. KaprioJ. VirolainenP. PulkkiK. KilpiT. PerolaM. PartanenJ. PitkärantaA. KaarteenahoR. VainioS. TurpeinenM. SerpiR. LaitinenT. MäkeläJ. KosmaV-M. KujalaU. TuovilaO. HendolinM. PakkanenR. WaringJ. Riley-GillisB. LiuJ. BiswasS. DiogoD. MarshallC. HuX. GosselM. GrahamR. CummingsB. RipattiS. SchleutkerJ. ArvasM. CarpénO. HinttalaR. KettunenJ. MannermaaA. LaukkanenJ. JulkunenV. RemesA. KälviäinenR. PeltolaJ. TienariP. RinneJ. ZiemannA. WaringJ. EsmaeeliS. SmaouiN. LehtonenA. EatonS. LahdenperäS. van AdelsbergJ. MichonJ. KerchnerG. BowersN. TengE. EicherJ. MehtaV. GormleyP. LindenK. WhelanC. XuF. PulfordD. FärkkiläM. PikkarainenS. JussilaA. BlomsterT. KiviniemiM. VoutilainenM. GeorgantasB. HeapG. RahimovF. UsiskinK. LuT. OhD. KalpalaK. MillerM. McCarthyL. EklundK. PalomäkiA. IsomäkiP. PiriläL. Kaipiainen-SeppänenO. HuhtakangasJ. LertratanakulA. HochfeldM. BingN. GordilloJ.E. MarsN. PelkonenM. KauppiP. KankaanrantaH. HarjuT. CloseD. GreenbergS. ChenH. BettsJ. GhoshS. SalomaaV. NiiranenT. JuonalaM. MetsärinneK. KähönenM. JunttilaJ. LaaksoM. PihlajamäkiJ. SinisaloJ. TaskinenM-R. TuomiT. ChallisB. PetersonA. ChuA. ParkkinenJ. MuslinA. JoensuuH. MeretojaT. AaltonenL. MattsonJ. AuranenA. KarihtalaP. KauppilaS. AuvinenP. EleniusK. PopovicR. SchutzmanJ. LobodaA. ChhibberA. LehtonenH. McDonoughS. CrohnsM. KulkarniD. KaarnirantaK. TurunenJ.A. OllilaT. SeitsonenS. UusitaloH. AaltonenV. Uusitalo-JärvinenH. LuodonpääM. HautalaN. LoomisS. StraussE. ChenH. PodgornaiaA. HoffmanJ. TasanenK. HuilajaL. Hannula-JouppiK. SalmiT. PeltonenS. KouluL. HarvimaI. WuY. ChoyD. PussinenP. SalminenA. SaloT. RiceD. NieminenP. PalotieU. SiponenM. SuominenL. MäntyläP. GursoyU. AnttonenV. SipiläK. DavisJ.W. QuarlessD. PetrovskiS. WigmoreE. ChenC-Y. BronsonP. TsaiE. HuangY. MaranvilleJ. ShaikhoE. MohammedE. WadhawanS. KvikstadE. CaliskanM. ChangD. BhangaleT. PendergrassS. HolzingerE. ChenX. HedmanÅ. KingK.S. WangC. XuE. AugeF. ChatelainC. RajpalD. LiuD. CallK. XiaT. BrauerM. KurkiM. KarjalainenJ. HavulinnaA. JalankoA. PaltaP. della Briotta ParoloP. ZhouW. LemmeläS. RivasM. HarjuJ. LehistoA. GannaA. LlorensV. LaivuoriH. RüegerS. NiemiM.E. TukiainenT. ReeveM.P. HeyneH. PalinK. Garcia-TabuencaJ. SiirtolaH. KiiskinenT. LeeJ. TsuoK. ElliottA. KristianssonK. HyvärinenK. RitariJ. KoskinenM. PylkäsK. KalaojaM. KarjalainenM. MantereT. KangasniemiE. HeikkinenS. LaakkonenE. SipekyC. HeronS. KarlssonA. JambulingamD. RathinakannanV.S. KajanneR. AavikkoM. JiménezM.G. della Briotta ParolaP. LehistöA. KanaiM. KaunistoM. KilpeläinenE. SipiläT.P. BreinG. AwaisaG. ShcherbanA. DonnerK. LoukolaA. LaihoP. SistonenT. KaiharjuE. LaukkanenM. JärvensivuE. LähteenmäkiS. MännikköL. WongR. MattssonH. HiekkalinnaT. PaajanenT. PärnK. Gracia-TabuencaJ. AbnerE. AdamsP.M. AguirreA. AlbertM.S. AlbinR.L. AllenM. AlvarezL. ApostolovaL.G. ArnoldS.E. AsthanaS. AtwoodC.S. AyresG. BaldwinC.T. BarberR.C. BarnesL.L. BarralS. BeachT.G. BeckerJ.T. BeechamG.W. BeeklyD. BelowJ.E. BenchekP. BenitezB.A. BennettD. BertelsonJ. MargaretF.E. BirdT.D. BlackerD. BoeveB.F. BowenJ.D. BoxerA. BrewerJ. BurkeJ.R. BurnsJ.M. BushW.S. BuxbaumJ.D. CairnsN.J. CaoC. CarlsonC.S. CarlssonC.M. CarneyR.M. CarrasquilloM.M. ChasseS. ChesseletM-F. ChesiA. ChinN.A. ChuiH.C. ChungJ. CraftS. CraneP.K. CribbsD.H. CroccoE.A. CruchagaC. CuccaroM.L. CullumM. DarbyE. DavisB. De JagerP.L. DeCarliC. DeToledoJ. DickM. DicksonD.W. DombroskiB.A. DoodyR.S. DuaraR. Ertekin-TanerN. EvansD.A. FairchildT.J. FallonK.B. FarlowM.R. FarrellJ.J. Fernandez-HernandezV. FerrisS. FroschM.P. Fulton-HowardB. GalaskoD.R. GamboaA. GearingM. GeschwindD.H. GhettiB. GilbertJ.R. GrabowskiT.J. Graff-RadfordN.R. GrantS.F.A. GreenR.C. GrowdonJ.H. HainesJ.L. HakonarsonH. HallJ. HamiltonR.L. HarariO. HarrellL.E. HautJ. HeadE. HendersonV.W. HernandezM. HohmanT. HonigL.S. HuebingerR.M. HuentelmanM.J. HuletteC.M. HymanB.T. HynanL.S. IbanezL. JarvikG.P. JayadevS. JinL-W. JohnsonK. JohnsonL. KambohM.I. KarydasA.M. KatzM.J. KayeJ.A. KeeneC.D. KhaleeqA. KimR. KneblJ. KowallN.W. KramerJ.H. KuksaP.P. LaFerlaF.M. LahJ.J. LarsonE.B. LeeC-Y. LeeE.B. LernerA. LeungY.Y. LeverenzJ.B. LeveyA.I. LiM. LiebermanA.P. LiptonR.B. LogueM. LyketsosC.G. MalamonJ. MainsD. MarsonD.C. MartiniukF. MashD.C. MasliahE. MassmanP. MasurkarA. McCormickW.C. McCurryS.M. McDavidA.N. McDonoughS. McKeeA.C. MesulamM. MezJ. MillerB.L. MillerC.A. MillerJ.W. MontineT.J. MonukiE.S. MorrisJ.C. MyersA.J. NguyenT. O’BryantS. OlichneyJ.M. OryM. PalmerR. ParisiJ.E. PaulsonH.L. PavlikV. PaydarfarD. PerezV. PeskindE. PetersenR.C. Phillips-CreminsJ.E. PierceA. PolkM. PoonW.W. PotterH. QuL. QuicenoM. QuinnJ.F. RajA. RaskindM. ReimanE.M. ReisbergB. ReischJ.S. RingmanJ.M. RobersonE.D. RodriguearM. RogaevaE. RosenH.J. RosenbergR.N. RoyallD.R. SagerM.A. SanoM. SaykinA.J. SchneiderJ.A. SchneiderL.S. SeeleyW.W. SliferS.H. SmallS. SmithA.G. SmithJ.P. SongY.E. SonnenJ.A. SpinaS. George-HyslopP.S. SternR.A. StevensA.B. StrittmatterS.M. SultzerD. SwerdlowR.H. TanziR.E. TilsonJ.L. TrojanowskiJ.Q. TroncosoJ.C. TsuangD.W. ValladaresO. Van DeerlinV.M. van EldikL.J. VassarR. VintersH.V. VonsattelJ-P. WeintraubS. Welsh-BohmerK.A. WhiteheadP.L. WijsmanE.M. WilhelmsenK.C. WilliamsB. WilliamsonJ. WilmsH. WingoT.S. WisniewskiT. WoltjerR.L. WoonM. WrightC.B. WuC-K. YounkinS.G. YuC-E. YuL. ZhangY. ZhaoY. ZhuX. AdamsH. AkinyemiR.O. AliM. ArmstrongN. AparicioH.J. BahadoriM. BeckerJ.T. BretelerM. ChasmanD. ChauhanG. ComicH. CoxS. CupplesA.L. DaviesG. DeCarliC.S. DuperronM-G. DupuisJ. EvansT. FanF. FitzpatrickA. FohnerA.E. GanguliM. GeerlingsM. GlattS.J. GonzalezH.M. GossM. GrabeH. HabesM. HeckbertS.R. HoferE. HongE. HughesT. KautzT.F. KnolM. KremenW. LacazeP. LahtiJ. GrandQ.L. LitkowskiE. LiS. LiuD. LiuX. LoitfelderM. ManningA. MaillardP. MarioniR. MazoyerB. van LentD.M. MeiH. MishraA. NyquistP. O’ConnellJ. PatelY. PausT. PausovaZ. Raikkonen-TalvitieK. RiazM. RichS. RotterJ. RomeroJ. RoshchupkinG. SabaY. SargurupremrajM. SchmidtH. SchmidtR. ShulmanJ.M. SmithJ. SekharH. RajulaR. ShinJ. SiminoJ. SlizE. TeumerA. ThomasA. TinA. Tucker-DrobE. VojinovicD. WangY. WeinsteinG. WilliamsD. WittfeldK. YanekL. YangY. FarrerL.A. PsatyB.M. GhanbariM. RajT. SachdevP. MatherK. JessenF. IkramM.A. de MendonçaA. HortJ. TsolakiM. Pericak-VanceM.A. AmouyelP. WilliamsJ. Frikke-SchmidtR. ClarimonJ. DeleuzeJ-F. RossiG. SeshadriS. AndreassenO.A. IngelssonM. HiltunenM. SleegersK. SchellenbergG.D. van DuijnC.M. SimsR. van der FlierW.M. RuizA. RamirezA. LambertJ-C. New insights into the genetic etiology of Alzheimer’s disease and related dementias.Nat. Genet.202254441243610.1038/s41588‑022‑01024‑z35379992
    [Google Scholar]
  35. SierksmaA. Escott-PriceV. De StrooperB. Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets.Science20203706512616610.1126/science.abb857533004512
    [Google Scholar]
  36. LeonenkoG. BakerE. Stevenson-HoareJ. SierksmaA. FiersM. WilliamsJ. de StrooperB. Escott-PriceV. Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores.Nat. Commun.2021121450610.1038/s41467‑021‑24082‑z34301930
    [Google Scholar]
  37. ZhouX. ChenY. IpF.C.F. JiangY. CaoH. LvG. ZhongH. ChenJ. YeT. ChenY. ZhangY. MaS. LoR.M.N. TongE.P.S. WeinerM.W. AisenP. PetersenR. JackC.R. JagustW. TrojanowskiJ.Q. TogaA.W. BeckettL. GreenR.C. SaykinA.J. MorrisJ. ShawL.M. KhachaturianZ. SorensenG. KullerL. RaichleM. PaulS. DaviesP. FillitH. HeftiF. HoltzmanD. MesulamM.M. PotterW. SnyderP. SchwartzA. MontineT. ThomasR.G. DonohueM. WalterS. GessertD. SatherT. JiminezG. HarveyD. BernsteinM. ThompsonP. SchuffN. BorowskiB. GunterJ. SenjemM. VemuriP. JonesD. KantarciK. WardC. KoeppeR.A. FosterN. ReimanE.M. ChenK. MathisC. LandauS. CairnsN.J. HouseholderE. Taylor-ReinwaldL. LeeV. KoreckaM. FigurskiM. CrawfordK. NeuS. ForoudT.M. PotkinS.G. ShenL. FaberK. KimS. NhoK. ThalL. BuckholtzN. AlbertM. FrankR. HsiaoJ. KayeJ. QuinnJ. LindB. CarterR. DolenS. SchneiderL.S. PawluczykS. BecceraM. TeodoroL. SpannB.M. BrewerJ. VanderswagH. FleisherA. HeidebrinkJ.L. LordJ.L. MasonS.S. AlbersC.S. KnopmanD. JohnsonK. DoodyR.S. Villanueva-MeyerJ. ChowdhuryM. RountreeS. DangM. SternY. HonigL.S. BellK.L. AncesB. CarrollM. LeonS. MintunM.A. SchneiderS. OliverA. MarsonD. GriffithR. ClarkD. GeldmacherD. BrockingtonJ. RobersonE. GrossmanH. MitsisE. de Toledo-MorrellL. ShahR.C. DuaraR. VaronD. GreigM.T. RobertsP. OnyikeC. D’AgostinoD. KielbS. GalvinJ.E. CerboneB. MichelC.A. RusinekH. de LeonM.J. GlodzikL. De SantiS. DoraiswamyP.M. PetrellaJ.R. WongT.Z. ArnoldS.E. KarlawishJ.H. WolkD. SmithC.D. JichaG. HardyP. SinhaP. OatesE. ConradG. LopezO.L. OakleyM.A. SimpsonD.M. PorsteinssonA.P. GoldsteinB.S. MartinK. MakinoK.M. IsmailM.S. BrandC. MulnardR.A. ThaiG. McAdams-OrtizC. WomackK. MathewsD. QuicenoM. Diaz-ArrastiaR. KingR. WeinerM. Martin-CookK. DeVousM. LeveyA.I. LahJ.J. CellarJ.S. BurnsJ.M. AndersonH.S. SwerdlowR.H. ApostolovaL. TingusK. WooE. SilvermanD.H.S. LuP.H. BartzokisG. Graff-RadfordN.R. ParfittF. KendallT. JohnsonH. FarlowM.R. HakeA.M. MatthewsB.R. HerringS. HuntC. van DyckC.H. CarsonR.E. MacAvoyM.G. ChertkowH. BergmanH. HoseinC. HsiungG-Y.R. FeldmanH. MudgeB. AssalyM. BernickC. MunicD. KerteszA. RogersJ. TrostD. KerwinD. LipowskiK. WuC-K. JohnsonN. SadowskyC. MartinezW. VillenaT. TurnerR.S. JohnsonK. ReynoldsB. SperlingR.A. JohnsonK.A. MarshallG. FreyM. LaneB. RosenA. TinklenbergJ. SabbaghM.N. BeldenC.M. JacobsonS.A. SirrelS.A. KowallN. KillianyR. BudsonA.E. NorbashA. JohnsonP.L. AllardJ. LernerA. OgrockiP. HudsonL. FletcherE. CarmichaelO. OlichneyJ. DeCarliC. KitturS. BorrieM. LeeT-Y. BarthaR. JohnsonS. AsthanaS. CarlssonC.M. PredaA. NguyenD. TariotP. ReederS. BatesV. CapoteH. RainkaM. ScharreD.W. KatakiM. AdeliA. ZimmermanE.A. CelminsD. BrownA.D. PearlsonG.D. BlankK. AndersonK. SantulliR.B. KitzmillerT.J. SchwartzE.S. SinkK.M. WilliamsonJ.D. GargP. WatkinsF. OttB.R. QuerfurthH. TremontG. SallowayS. MalloyP. CorreiaS. RosenH.J. MillerB.L. MintzerJ. SpicerK. BachmanD. PasternakS. RachinskyI. DrostD. PomaraN. HernandoR. SarraelA. SchultzS.K. Boles PontoL.L. ShimH. SmithK.E. RelkinN. ChaingG. RaudinL. SmithA. FargherK. RajB.A. NeylanT. GrafmanJ. DavisM. MorrisonR. HayesJ. FinleyS. FriedlK. FleischmanD. ArfanakisK. JamesO. MassogliaD. FruehlingJ.J. HardingS. PeskindE.R. PetrieE.C. LiG. YesavageJ.A. TaylorJ.L. FurstA.J. MokV.C.T. KwokT.C.Y. GuoQ. MokK.Y. ShoaiM. HardyJ. ChenL. FuA.K.Y. IpN.Y. Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction.Commun. Med.2023314910.1038/s43856‑023‑00269‑x37024668
    [Google Scholar]
  38. WeiW. VisweswaranS. CooperG.F. The application of naive Bayes model averaging to predict Alzheimer’s disease from genome-wide data.J. Am. Med. Inform. Assoc.201118437037510.1136/amiajnl‑2011‑00010121672907
    [Google Scholar]
  39. LundbergM. SngL.M.F. SzulP. DunneR. BayatA. BurnhamS.C. BauerD.C. TwineN.A. Novel Alzheimer’s disease genes and epistasis identified using machine learning GWAS platform.Sci. Rep.20231311766210.1038/s41598‑023‑44378‑y37848535
    [Google Scholar]
  40. ShigemizuD. AkiyamaS. SuganumaM. FurutaniM. YamakawaA. NakanoY. OzakiK. NiidaS. Classification and deep-learning–based prediction of Alzheimer disease subtypes by using genomic data.Transl. Psychiatry202313123210.1038/s41398‑023‑02531‑137386009
    [Google Scholar]
  41. XieZ. SituY. DengL. LiangM. DingH. GuoZ. XuQ. LiangZ. ShaoZ. Identification of therapeutic targets for Alzheimer’s Disease Treatment using bioinformatics and machine learning.Sci. Rep.2025151388810.1038/s41598‑025‑88134‑w39890844
    [Google Scholar]
  42. KivimäkiM. LivingstonG. Singh-ManouxA. MarsN. LindbohmJ.V. PenttiJ. NybergS.T. PirinenM. AndersonE.L. HingoraniA.D. SipiläP.N. Estimating dementia risk using multifactorial prediction models.JAMA Netw. Open202366e231813210.1001/jamanetworkopen.2023.1813237310738
    [Google Scholar]
  43. FerreiraP.C.L. ZhangY. SnitzB. ChangC.C.H. BellaverB. JacobsenE. KambohM.I. ZetterbergH. BlennowK. PascoalT.A. VillemagneV.L. GanguliM. KarikariT.K. Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population-based cohort.Alzheimers Dement.202319104507451910.1002/alz.1298636876954
    [Google Scholar]
  44. YouJ. ZhangY.R. WangH.F. YangM. FengJ.F. YuJ.T. ChengW. Development of a novel dementia risk prediction model in the general population: A large, longitudinal, population-based machine-learning study.EClin. Med.20225310166510.1016/j.eclinm.2022.10166536187723
    [Google Scholar]
  45. TangA.S. RankinK.P. CeronoG. MiramontesS. MillsH. RogerJ. ZengB. NelsonC. SomanK. WoldemariamS. LiY. LeeA. BoveR. GlymourM. AghaeepourN. OskotskyT.T. MillerZ. AllenI.E. SandersS.J. BaranziniS. SirotaM. Leveraging electronic health records and knowledge networks for Alzheimer’s disease prediction and sex-specific biological insights.Nature Aging20244337939510.1038/s43587‑024‑00573‑838383858
    [Google Scholar]
  46. DuaraR. BarkerW. Heterogeneity in Alzheimer’s disease diagnosis and progression rates: Implications for therapeutic trials.Neurotherapeutics202219182510.1007/s13311‑022‑01185‑z35084721
    [Google Scholar]
  47. KovacsG.G. Clinical stratification of subtypes of Alzheimer’s disease.Lancet Neurol.2012111083984110.1016/S1474‑4422(12)70209‑022995685
    [Google Scholar]
  48. PatilS. KukrejaS. Early detection of cognitive decline with deep learning and graph-based modeling.MethodsX20251410340510.1016/j.mex.2025.10340540567946
    [Google Scholar]
  49. TopolE. Predicting and preventing Alzheimer’s disease.Science20253886750eady321710.1126/science.ady321740440380
    [Google Scholar]
  50. SaleemT.J. ZahraS.R. WuF. AlwakeelA. AlwakeelM. JeribiF. HijjiM. Deep learning-based diagnosis of Alzheimer’s disease.J. Pers. Med.202212581510.3390/jpm1205081535629237
    [Google Scholar]
  51. MárquezF. YassaM.A. Neuroimaging biomarkers for Alzheimer’s disease.Mol. Neurodegener.20191412110.1186/s13024‑019‑0325‑531174557
    [Google Scholar]
  52. KangJ. CaffoB. LiuH. Editorial: Recent advances and challenges on big data analysis in neuroimaging.Front. Neurosci.20161050510.3389/fnins.2016.0050527895547
    [Google Scholar]
  53. EtminaniK. SolimanA. DavidssonA. ChangJ.R. Martínez-SanchisB. ByttnerS. CamachoV. BaucknehtM. StegeranR. RessnerM. Agudelo-CifuentesM. ChincariniA. BrendelM. RomingerA. BruffaertsR. VandenbergheR. KrambergerM.G. TrostM. NicastroN. FrisoniG.B. LemstraA.W. van BerckelB.N.M. PilottoA. PadovaniA. MorbelliS. AarslandD. NobiliF. GaribottoV. Ochoa-FigueroaM. A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer’s disease, and mild cognitive impairment using brain 18F-FDG PET.Eur. J. Nucl. Med. Mol. Imaging202249256358410.1007/s00259‑021‑05483‑034328531
    [Google Scholar]
  54. ZhuW. SunL. HuangJ. HanL. ZhangD. Dual attention multi-instance deep learning for Alzheimer’s disease diagnosis with structural MRI.IEEE Trans. Med. Imaging20214092354236610.1109/TMI.2021.307707933939609
    [Google Scholar]
  55. HassanN. MiahA.S.M. SuzukiK. OkuyamaY. ShinJ. Stacked CNN-based multichannel attention networks for Alzheimer disease detection.Sci. Rep.2025151581510.1038/s41598‑025‑85703‑x39962097
    [Google Scholar]
  56. KimJ.S. HanJ.W. BaeJ.B. MoonD.G. ShinJ. KongJ.E. LeeH. YangH.W. LimE. KimJ.Y. SunwooL. ChoS.J. LeeD. KimI. HaS.W. KangM.J. SuhC.H. ShimW.H. KimS.J. KimK.W. Deep learning-based diagnosis of Alzheimer’s disease using brain magnetic resonance images: An empirical study.Sci. Rep.20221211800710.1038/s41598‑022‑22917‑336289390
    [Google Scholar]
  57. de VriesB.M. GollaS.S.V. EbenauJ. VerfaillieS.C.J. TimmersT. HeemanF. CysouwM.C.F. van BerckelB.N.M. van der FlierW.M. YaqubM. BoellaardR. Classification of negative and positive 18F-florbetapir brain PET studies in subjective cognitive decline patients using a convolutional neural network.Eur. J. Nucl. Med. Mol. Imaging202148372172810.1007/s00259‑020‑05006‑332875431
    [Google Scholar]
  58. RakvongthaiY. PatipipittanaS. AI-powered FDG-PET radiomics: A door to better Alzheimer’s disease classification?Eur. Radiol.20253552617261910.1007/s00330‑025‑11381‑y39870903
    [Google Scholar]
  59. FanS. PonisioM.R. XiaoP. HaS.M. ChakrabartyS. LeeJ.J. FloresS. LaMontagneP. GordonB. RajiC.A. MarcusD.S. NazeriA. AncesB.M. BatemanR.J. MorrisJ.C. BenzingerT.L.S. SotirasA. AmyloidPETNet: Classification of amyloid positivity in brain PET imaging using end-to-end deep learning.Radiology20243113e23144210.1148/radiol.23144238860897
    [Google Scholar]
  60. YeB. ChuC.H. BayatS. BabineauJ. HowT.V. MihailidisA. Researched apps used in dementia care for people living with dementia and their informal caregivers: Systematic review on app features, security, and usability.J. Med. Internet Res.202325e4618810.2196/4618837824187
    [Google Scholar]
  61. El-SappaghS. AlonsoJ.M. IslamS.M.R. SultanA.M. KwakK.S. A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer’s disease.Sci. Rep.2021111266010.1038/s41598‑021‑82098‑333514817
    [Google Scholar]
  62. BucholcM. DingX. WangH. GlassD.H. WangH. PrasadG. MaguireL.P. BjoursonA.J. McCleanP.L. ToddS. FinnD.P. Wong-LinK. A practical computerized decision support system for predicting the severity of Alzheimer’s disease of an individual.Expert Syst. Appl.201913015717110.1016/j.eswa.2019.04.02231402810
    [Google Scholar]
  63. LinW. GaoQ. YuanJ. ChenZ. FengC. ChenW. DuM. TongT. Predicting Alzheimer’s disease conversion from mild cognitive impairment using an extreme learning machine-based grading method with multimodal data.Front. Aging Neurosci.2020127710.3389/fnagi.2020.0007732296326
    [Google Scholar]
  64. BuchmanA.S. BennettD.A. Loss of motor function in preclinical Alzheimer’s disease.Expert Rev. Neurother.201111566567610.1586/ern.11.5721539487
    [Google Scholar]
  65. YanJ.H. RountreeS. MassmanP. DoodyR.S. LiH. Alzheimer’s disease and mild cognitive impairment deteriorate fine movement control.J. Psychiatr. Res.200842141203121210.1016/j.jpsychires.2008.01.00618280503
    [Google Scholar]
  66. QiY. ZhuX. XiongX. YangX. DingN. WuH. XuK. ZhuJ. ZhangJ. WangY. Human motor cortex encodes complex handwriting through a sequence of stable neural states.Nat. Hum. Behav.2025961260127110.1038/s41562‑025‑02157‑x40175631
    [Google Scholar]
  67. SweidanJ. El-YacoubiM.A. RigaudA.S. Explainability of CNN-based Alzheimer’s disease detection from online handwriting.Sci. Rep.20241412210810.1038/s41598‑024‑72650‑239333681
    [Google Scholar]
  68. NardoneE. De StefanoC. CiliaN.D. FontanellaF. Handwriting strokes as biomarkers for Alzheimer’s disease prediction: A novel machine learning approach.Comput. Biol. Med.202519011003910.1016/j.compbiomed.2025.11003940158458
    [Google Scholar]
  69. HaoJ. KwapongW.R. ShenT. FuH. XuY. LuQ. LiuS. ZhangJ. LiuY. ZhaoY. ZhengY. FrangiA.F. ZhangS. QiH. ZhaoY. Early detection of dementia through retinal imaging and trustworthy AI.NPJ Digit. Med.20247129410.1038/s41746‑024‑01292‑539428420
    [Google Scholar]
  70. CheungC.Y. RanA.R. WangS. ChanV.T.T. ShamK. HilalS. VenketasubramanianN. ChengC.Y. SabanayagamC. ThamY.C. SchmettererL. McKayG.J. WilliamsM.A. WongA. AuL.W.C. LuZ. YamJ.C. ThamC.C. ChenJ.J. DumitrascuO.M. HengP.A. KwokT.C.Y. MokV.C.T. MileaD. ChenC.L.H. WongT.Y. A deep learning model for detection of Alzheimer’s disease based on retinal photographs: a retrospective, multicentre case-control study.Lancet Digit. Health2022411e806e81510.1016/S2589‑7500(22)00169‑836192349
    [Google Scholar]
  71. AcharyaM. DeoR.C. TaoX. BaruaP.D. DeviA. AtmakuruA. TanR.S. Deep learning techniques for automated Alzheimer’s and mild cognitive impairment disease using EEG signals: A comprehensive review of the last decade (2013 - 2024).Comput. Methods Programs Biomed.202525910850610.1016/j.cmpb.2024.10850639581069
    [Google Scholar]
  72. TrögerJ. LinzN. KönigA. RobertP. AlexanderssonJ. PeterJ. KrayJ. Exploitation vs. exploration - computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer’s disease.Neuropsychologia2019131536110.1016/j.neuropsychologia.2019.05.00731121184
    [Google Scholar]
  73. ChimamiwaG. GiarettaA. AlirezaieM. PecoraF. LoutfiA. Are smart homes adequate for older adults with dementia?Sensors20222211425410.3390/s2211425435684874
    [Google Scholar]
  74. PossinK.L. BurnsJ.M. ForesterB.P. Collaborative dementia care during the new therapeutic era.JAMA Neurol.202481121241124210.1001/jamaneurol.2024.337939401023
    [Google Scholar]
  75. ShuS. WooB.K.P. Use of technology and social media in dementia care: Current and future directions.World J. Psychiatry202111410912310.5498/wjp.v11.i4.10933889536
    [Google Scholar]
  76. MoonS. ParkK. The effect of digital reminiscence therapy on people with dementia: A pilot randomized controlled trial.BMC Geriatr.202020116610.1186/s12877‑020‑01563‑232375661
    [Google Scholar]
  77. HussainM. AliT. KhanW.A. AfzalM. LeeS. LatifK. Recommendations service for chronic disease patient in multimodel sensors home environment.Telemed. J. E Health201521318519910.1089/tmj.2014.002825559934
    [Google Scholar]
  78. ThyrianJ.R. HertelJ. WuchererD. EichlerT. MichalowskyB. Dreier-WolfgrammA. ZwingmannI. KilimannI. TeipelS. HoffmannW. Effectiveness and safety of dementia care management in primary care.JAMA Psychiatry20177410996100410.1001/jamapsychiatry.2017.212428746708
    [Google Scholar]
  79. HasanW.U. ZamanK.T. WangX. LiJ. XieB. TaoC. Empowering Alzheimer’s caregivers with conversational AI: A novel approach for enhanced communication and personalized support.npj Biomed. Innov.202411310.1038/s44385‑024‑00004‑8
    [Google Scholar]
  80. VatanseverS. SchlessingerA. WackerD. KaniskanH.Ü. JinJ. ZhouM.M. ZhangB. Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions.Med. Res. Rev.20214131427147310.1002/med.2176433295676
    [Google Scholar]
  81. TsujiS. HaseT. Yachie-KinoshitaA. NishinoT. GhoshS. KikuchiM. ShimokawaK. AburataniH. KitanoH. TanakaH. Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease.Alzheimers Res. Ther.20211319210.1186/s13195‑021‑00826‑333941241
    [Google Scholar]
  82. WuT. LinR. CuiP. YongJ. YuH. LiZ. Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer’s disease.J. Pharm. Anal.2024141010102210.1016/j.jpha.2024.10102239850238
    [Google Scholar]
  83. DasB. MathewA.T. BaidyaA.T.K. DeviB. SalmonR.R. KumarR. Artificial intelligence assisted identification of potential tau aggregation inhibitors: Ligand- and structure-based virtual screening, in silico ADME, and molecular dynamics study.Mol. Divers.20242842013203110.1007/s11030‑023‑10645‑337022608
    [Google Scholar]
  84. XieC. ZhuangX.X. NiuZ. AiR. LautrupS. ZhengS. JiangY. HanR. GuptaT.S. CaoS. Lagartos-DonateM.J. CaiC.Z. XieL.M. CaponioD. WangW.W. Schmauck-MedinaT. ZhangJ. WangH. LouG. XiaoX. ZhengW. PalikarasK. YangG. CaldwellK.A. CaldwellG.A. ShenH.M. NilsenH. LuJ.H. FangE.F. Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.Nat. Biomed. Eng.202261769310.1038/s41551‑021‑00819‑534992270
    [Google Scholar]
  85. VaghariD. MohankumarG. TanK. LoweA. SheringC. TinoP. KourtziZ. AI-guided patient stratification improves outcomes and efficiency in the AMARANTH Alzheimer’s Disease clinical trial.Nat. Commun.2025161624410.1038/s41467‑025‑61355‑340675957
    [Google Scholar]
  86. ZulhafizN.A. TeohT.C. ChinA.V. ChangS.W. Drug repurposing using artificial intelligence, molecular docking, and hybrid approaches: A comprehensive review in general diseases vs Alzheimer’s disease.Comput. Methods Programs Biomed.202526110860410.1016/j.cmpb.2025.10860439826482
    [Google Scholar]
  87. YanC. GrabowskaM.E. DicksonA.L. LiB. WenZ. RodenD.M. Michael SteinC. EmbíP.J. PetersonJ.F. FengQ. MalinB.A. WeiW.Q. Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation.NPJ Digit. Med.2024714610.1038/s41746‑024‑01038‑338409350
    [Google Scholar]
  88. GrabowskaM.E. HuangA. WenZ. LiB. WeiW.Q. Drug repurposing for Alzheimer’s disease from 2012–2022 - A 10-year literature review.Front. Pharmacol.202314125770010.3389/fphar.2023.125770037745051
    [Google Scholar]
  89. PushpakomS. IorioF. EyersP.A. EscottK.J. HopperS. WellsA. DoigA. GuilliamsT. LatimerJ. McNameeC. NorrisA. SanseauP. CavallaD. PirmohamedM. Drug repurposing: Progress, challenges and recommendations.Nat. Rev. Drug Discov.2019181415810.1038/nrd.2018.16830310233
    [Google Scholar]
  90. FangJ. ZhangP. WangQ. ChiangC.W. ZhouY. HouY. XuJ. ChenR. ZhangB. LewisS.J. LeverenzJ.B. PieperA.A. LiB. LiL. CummingsJ. ChengF. Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease.Alzheimers Res. Ther.2022141710.1186/s13195‑021‑00951‑z35012639
    [Google Scholar]
  91. QiuY. ChengF. Artificial intelligence for drug discovery and development in Alzheimer’s disease.Curr. Opin. Struct. Biol.20248510277610.1016/j.sbi.2024.10277638335558
    [Google Scholar]
  92. WithersC.A. RufaiA.M. VenkatesanA. TirunagariS. LobentanzerS. HarrisonM. ZdrazilB. Natural language processing in drug discovery: Bridging the gap between text and therapeutics with artificial intelligence.Expert Opin. Drug Discov.202520676578310.1080/17460441.2025.249083540298230
    [Google Scholar]
  93. AI’s potential to accelerate drug discovery needs a reality check.Nature2023622798221710.1038/d41586‑023‑03172‑637817040
    [Google Scholar]
  94. LiZ. JiangX. WangY. KimY. Applied machine learning in Alzheimer’s disease research: Omics, imaging, and clinical data.Emerg. Top. Life Sci.20215676577710.1042/ETLS2021024934881778
    [Google Scholar]
  95. BeheshtiI. AlbensiB.C. FreitasA. GhafourianT. Advancements and challenges in using AI for biomarker detection in early Alzheimer’s disease.Drug Discov. Today202530710441510.1016/j.drudis.2025.10441540545029
    [Google Scholar]
  96. van der FlierW.M. de VugtM.E. SmetsE.M.A. BlomM. TeunissenC.E. Towards a future where Alzheimer’s disease pathology is stopped before the onset of dementia.Nature Aging20233549450510.1038/s43587‑023‑00404‑237202515
    [Google Scholar]
  97. WeinerM.W. VeitchD.P. AisenP.S. BeckettL.A. CairnsN.J. GreenR.C. HarveyD. JackC.R.Jr JagustW. MorrisJ.C. PetersenR.C. SalazarJ. SaykinA.J. ShawL.M. TogaA.W. TrojanowskiJ.Q. The Alzheimer’s disease neuroimaging initiative 3: Continued innovation for clinical trial improvement.Alzheimers Dement.201713556157110.1016/j.jalz.2016.10.00627931796
    [Google Scholar]
  98. QiW. ZhuX. HeD. WangB. CaoS. DongC. LiY. ChenY. WangB. ShiY. JiangG. LiuF. BootsL.M.M. LiJ. LouX. YaoJ. LuX. KangJ. Mapping knowledge landscapes and emerging trends in AI for dementia biomarkers: Bibliometric and visualization analysis.J. Med. Internet Res.202426e5783010.2196/5783039116438
    [Google Scholar]
  99. FinlaysonS.G. SubbaswamyA. SinghK. BowersJ. KupkeA. ZittrainJ. KohaneI.S. SariaS. The clinician and dataset shift in artificial intelligence.N. Engl. J. Med.2021385328328610.1056/NEJMc210462634260843
    [Google Scholar]
  100. LyallD.M. KormilitzinA. LancasterC. SousaJ. Petermann-RochaF. BuckleyC. HarshfieldE.L. IvesonM.H. MadanC.R. McArdleR. NewbyD. OrgetaV. TangE. TamburinS. ThakurL.S. LouridaI. LlewellynD.J. RansonJ.M. Artificial intelligence for dementia - Applied models and digital health.Alzheimers Dement.202319125872588410.1002/alz.1339137496259
    [Google Scholar]
  101. LiQ. YangM.Q. Comparison of machine learning approaches for enhancing Alzheimer’s disease classification.PeerJ20219e1054910.7717/peerj.1054933665002
    [Google Scholar]
  102. KheraR. ButteA.J. BerkwitsM. HswenY. FlanaginA. ParkH. CurfmanG. Bibbins-DomingoK. AI in medicine-JAMA's focus on clinical outcomes, patient-centered care, quality, and equity.JAMA2023330981882010.1001/jama.2023.1548137566406
    [Google Scholar]
  103. BengioY. HintonG. YaoA. SongD. AbbeelP. DarrellT. HarariY.N. ZhangY.Q. XueL. Shalev-ShwartzS. HadfieldG. CluneJ. MaharajT. HutterF. BaydinA.G. McIlraithS. GaoQ. AcharyaA. KruegerD. DraganA. TorrP. RussellS. KahnemanD. BraunerJ. MindermannS. Managing extreme AI risks amid rapid progress.Science2024384669884284510.1126/science.adn011738768279
    [Google Scholar]
  104. KhalidN. QayyumA. BilalM. Al-FuqahaA. QadirJ. Privacy-preserving artificial intelligence in healthcare: Techniques and applications.Comput. Biol. Med.202315810684810.1016/j.compbiomed.2023.10684837044052
    [Google Scholar]
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