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2000
Volume 22, Issue 7
  • ISSN: 1567-2050
  • E-ISSN: 1875-5828

Abstract

Aims

This study aims, to trace the history of age-associated dementia from the earliest historical periods to the beginning of the modern age.

Background

Since the medical literature prior to the early 19th century is relatively scarce, the near absence of senile dementia has been hypothesized.

Objective

Verify the prevalence of senile dementia across different historical periods.

Methods

Beyond the medical literature, reviewed papers addressing legal and social aspects were examined to provide a comprehensive overview of the subject.

Results

While the medical literature on the subject is limited, there are a greater abundance of sources discussing social and legislative aspects. The scientific study of dementia had began only in the early 1800s.

Conclusion

In ancient times, dementia was not particularly rare, but it was often overlooked, as it was considered an inevitable consequence of aging.

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2025-12-08

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References

  1. RosenbergC.E. GoldenJ. Framing disease: Studies in cultural history.1992xiii
     [Google Scholar]
  2. LaslettP. The world we have lost: Further explored.RoutledgeLondon 2004.
     [Google Scholar]
  3. MinoisG. Histoire de la vieillesse en Occident.FayardParis 1987.
     [Google Scholar]
  4. ThaneP. Old age in english history.Oxford University PressOxford 2000.10.1093/oso/9780198203827.001.0001
     [Google Scholar]
  5. TroyanskyD.G. Aging in world history.RoutledgeLondon 2015.10.4324/9781315675183
     [Google Scholar]
  6. BattiscombeG.G. The instruction of ptah-hotep and the instruction of ke’gemni.John MurrayLondon 1906.
     [Google Scholar]
  7. BryanC.P. SmithG.E. Ancient egyptian medicine: The papyrus ebers.Ares PublishersChicago 1974.
     [Google Scholar]
  8. ReisnerG.A. The hearst medical papyrus.Hinrichs JCLeipzig 1905.
     [Google Scholar]
  9. BarakY. AchironA. Age related disorders in the Bible.Aging Ment. Health19982427527810.1080/13607869856515
     [Google Scholar]
  10. MatthewsV.H. MoyerJ.C. The old testament: Text and context.Baker Publishing Group 2012.
     [Google Scholar]
  11. LaertiusD. The lives and opinions of eminent philosophers.Bell and SonsLondon 1915.
     [Google Scholar]
  12. PhillipsD.D. The law of ancient athens.The University of Michigan PressUSA 2013.10.3998/mpub.336862
     [Google Scholar]
  13. GriffithT. SchofieldM. Plato: laws.Cambridge University PressCambridge 2016.10.1017/CBO9781139020800
     [Google Scholar]
  14. DymesT.J. Aristotle’s constitution of athens.Seeley and Co.London 1891.
     [Google Scholar]
  15. AdamsF. Hippocrates classics: Aphorisms.Kessinger PublishingUSA 2019.
     [Google Scholar]
  16. GreiveJ. Cornelius celsus of medicine.Gale EccoUSA 2018.
     [Google Scholar]
  17. CiceroM.T. Cicero De senectute: (Cato Major) a dialogue on old age.2022
     [Google Scholar]
  18. BlythT.A. A literal translation of the phormio of terence.Nabu PressFlorence 2010.
     [Google Scholar]
  19. CampbellR. Letters from a Stoic: Epistulae Morales Ad Lucilium.PenguinUSA 2004.
     [Google Scholar]
  20. HaynesM.S. The supposedly golden age for the aged in ancient rome (a study of literary concept of old age).Gerontologist196331263510.1093/geront/3.1.26
     [Google Scholar]
  21. OsbaldestonT.A. Dioscorides de Materia Medica.Ibidis PressJohannesburg, South Africa 2000.
     [Google Scholar]
  22. DarembergC. H. RuelleE. Works of rufus of ephesus, 1879.Baillière et FilsParis
     [Google Scholar]
  23. ReynoldsT.F. On the causes and signs of acute and chronic disease.PickeringLondon 1837.
     [Google Scholar]
  24. Montraville GreenR. A translation of galen’s hygiene: De sanitate tuenda.Literary LicensingUSA 2012.
     [Google Scholar]
  25. BussemakerD. DarembergC. Oeuvres d’Oribase, Tome Sixième.MolinierParis 1876.
     [Google Scholar]
  26. AdamsF. The seven books of Paulus Aegineta: Translated from the Greek with a commentary embracing a complete view of the knowledge possessed by the Greeks, Romans, and Arabians on all subjects connected with medicine and surgery.1864625-690.
     [Google Scholar]
  27. ScottS.P. Roman civil law.The Central Trust CompanyUSA 2014.
     [Google Scholar]
  28. LascaratosJ. KalantzisG. Poulakou-RebelakouE. Nursing homes for the old (‘Gerocomeia’) in Byzantium (324-1453 AD).Gerontology200450211311710.1159/00007556314963379
     [Google Scholar]
  29. BaloyannisS.J. BaloyannisS.J. Neurosciences in byzantine era.J. Neurol. Stroke20188420420610.15406/jnsk.2018.08.00310
     [Google Scholar]
  30. Poulakou-RebelakouE. KalantzisG. TsiamisC. PloumpidisD. Dementia on the Byzantine throne (ad 330–1453).Geriatr. Gerontol. Int.201212340541210.1111/j.1447‑0594.2011.00779.x22122672
     [Google Scholar]
  31. BrockS. St. Ephrem the Syrian: Hymns on Paradise.St. Vladimir's Seminary Press 1997.
     [Google Scholar]
  32. WhiteC. The rule of St. benedict.Penguin ClassicsUSA 2008.
     [Google Scholar]
  33. WallisF. Bede: The reckoning of time.Liverpool University Press 2009,101
     [Google Scholar]
  34. HowardD.R. On the misery of the human condition.The Bobbs-Merrill CompanyNew York 1969.
     [Google Scholar]
  35. ParkK. Doctor and medicine in early renaissance florence., 54-58. 1985,10.1515/9781400855001
     [Google Scholar]
  36. GottfriedR.S. Doctors and medicine in early renaissance England 1340-1530.1986, , 42-48.
     [Google Scholar]
  37. CrokeA. Regimen sanitatis salernitanum.TalboysLondon 1830.
     [Google Scholar]
  38. de Frutos GonzálezV. Guerrero PeralA.L. La neurología en los regimina sanitatis medievales.Neurología201126741642410.1016/j.nrl.2010.02.00621163197
     [Google Scholar]
  39. BergerD.S. BrewerS. Hildegard of bingen: On natural philosophy and medicine: Selections from cause et curae.University of Pennsylvania Press 1999.10.9783/9780812297812‑008
     [Google Scholar]
  40. LevE. Drugs held and sold by pharmacists of the Jewish community of medieval (11–14th centuries) Cairo according to lists of materia medica found at the Taylor–Schechter Genizah collection, Cambridge.J. Ethnopharmacol.2007110227529310.1016/j.jep.2006.09.04417113257
     [Google Scholar]
  41. BrowneR. The cure of old age and preservation of youth by roger bacon.EEBO EditionsUSA 2010.
     [Google Scholar]
  42. LindL.R. Gabriele Zerbi: Gerontocomia, on the care of the aged.American Philosophical SocietyPhiladelphia 1988.
     [Google Scholar]
  43. BurdellJ. The discourses and letters of louis cornaro, on a sober and temperate life.Palala PressUSA 2015.
     [Google Scholar]
  44. MillerC.H. Erasmus: The praise of folly.Yale University PressLondon 1979.
     [Google Scholar]
  45. MonneretC. Gold, a metal adorned with a thousand therapeutic virtues. 2015.
     [Google Scholar]
  46. SignoreG.C. History of pharmacy.,142172 2014,
    [Google Scholar]
  47. GoodeyC.F. “Foolishness” in early modern medicine and the concept of intellectual disability.Med. Hist.200448328931010.1017/S002572730000764X16021927
     [Google Scholar]
  48. BurtonR. Anatomy of melancholy.LongmanNY 1837.
     [Google Scholar]
  49. VossS.H. Descartes: The passions of the soul.Hackett PublishingUSA 1989.
     [Google Scholar]
  50. Boissier de SauvagesF. Methodical Nosology, Volume Seven.GouvionLyon 1772.
     [Google Scholar]
  51. PinelP. Medico-philosophical treatise on mental alienation.J.A. BrossonParis 1809.
     [Google Scholar]
  52. EsquirolE. Mental illnesses.,1838Vol. II
     [Google Scholar]
  53. DiefendorfA.R. Kraepelin Clinical Psychiatry.The McMillan CompanyLondon 1912.
     [Google Scholar]
  54. FinchC.E. BursteinS.M. Dementia in the ancient greco-roman world was minimally mentioned.J. Alzheimers Dis.20249741581158810.3233/JAD‑23099338277296
     [Google Scholar]
  55. RichardsonB.E. Old age among the ancient greeks.Hopkins PressUSA 1933.
     [Google Scholar]
  56. MontaguJ.D. Length of life in the ancient world: A controlled study.J. R. Soc. Med.1994871252610.1177/0141076894087001128308825
     [Google Scholar]
  57. RussellJ.C. Late ancient and medieval population.Transactions of the American Philosophical Society19584831152
     [Google Scholar]
  58. RowbothamJ. ClaytonP. An unsuitable and degraded diet? Part three: Victorian consumption patterns and their health benefits.J. R. Soc. Med.2008101945446210.1258/jrsm.2008.08011418779247
     [Google Scholar]
  59. FerriC.P. PrinceM. BrayneC. BrodatyH. FratiglioniL. GanguliM. HallK. HasegawaK. HendrieH. HuangY. JormA. MathersC. MenezesP.R. RimmerE. ScazufcaM. Global prevalence of dementia: A Delphi consensus study.Lancet200536695032112211710.1016/S0140‑6736(05)67889‑016360788
     [Google Scholar]
  60. LivingstonG. HuntleyJ. SommerladA. AmesD. BallardC. BanerjeeS. BrayneC. BurnsA. Cohen-MansfieldJ. CooperC. CostafredaS.G. DiasA. FoxN. GitlinL.N. HowardR. KalesH.C. KivimäkiM. LarsonE.B. OgunniyiA. OrgetaV. RitchieK. RockwoodK. SampsonE.L. SamusQ. SchneiderL.S. SelbækG. TeriL. MukadamN. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.Lancet20203961024841344610.1016/S0140‑6736(20)30367‑632738937
     [Google Scholar]
  61. GatzM. MackW.J. ChuiH.C. LawE.M. BarisanoG. SutherlandM.L. SutherlandJ.D. Eid RodriguezD. Quispe GutierrezR. Copajira AdrianJ. Bani CuataJ. BorensteinA.R. WaltersE.E. IrimiaA. RowanC.J. WannL.S. AllamA.H. ThompsonR.C. MiyamotoM.I. MichalikD.E. CummingsD.K. SeabrightE. GarciaA.R. HooperP.L. KraftT.S. FinchC.E. ThomasG.S. StieglitzJ. TrumbleB.C. GurvenM.D. KaplanH. Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.Alzheimers Dement.2023191445510.1002/alz.1262635262289
     [Google Scholar]
  62. KaplanH. ThompsonR.C. TrumbleB.C. WannL.S. AllamA.H. BeheimB. FrohlichB. SutherlandM.L. SutherlandJ.D. StieglitzJ. RodriguezD.E. MichalikD.E. RowanC.J. LombardiG.P. BediR. GarciaA.R. MinJ.K. NarulaJ. FinchC.E. GurvenM. ThomasG.S. Coronary atherosclerosis in indigenous South American Tsimane: A cross-sectional cohort study.Lancet2017389100801730173910.1016/S0140‑6736(17)30752‑328320601
     [Google Scholar]
  63. RowanC. J. EskanderM. A. SeabrightE. RodriguezD. E. LinaresE. C. GutierrezR. Q. AdrianJ. C. CummingsD. BeheimB. TolstrupK. AchrekarA. KraftT. MichalikD. E. MiyamotoM. I. AllamA. H. WannL. S. NarulaJ. TrumbleB. C. StieglitzJ. ThompsonR. C. ThomasG. S. KaplanH. S. GurvenM. D. Very low prevalence and incidence of atrial fibrillation among bolivian forager-farmers.Ann Glob Health20218711810.5334/aogh.325233633929
     [Google Scholar]
  64. IrimiaA. ChaudhariN.N. RoblesD.J. RostowskyK.A. MaherA.S. ChowdhuryN.F. CalvilloM. NgoV. GatzM. MackW.J. LawE.M. SutherlandM.L. SutherlandJ.D. RowanC.J. WannL.S. AllamA.H. ThompsonR.C. MichalikD.E. CummingsD.K. SeabrightE. AlamiS. GarciaA.R. HooperP.L. StieglitzJ. TrumbleB.C. GurvenM.D. ThomasG.S. FinchC.E. KaplanH. The indigenous south american tsimane exhibit relatively modest decrease in brain volume with age despite high systemic inflammation.J. Gerontol. A Biol. Sci. Med. Sci.202176122147215510.1093/gerona/glab13834038540
     [Google Scholar]
  65. ChaudhariN.N. ImmsP.E. ChowdhuryN.F. GatzM. TrumbleB.C. MackW.J. LawE.M. SutherlandM.L. SutherlandJ.D. RowanC.J. WannL.S. AllamA.H. ThompsonR.C. MichalikD.E. MiyamotoM. LombardiG. CummingsD.K. SeabrightE. AlamiS. GarciaA.R. RodriguezD.E. GutierrezR.Q. CopajiraA.J. HooperP.L. BuetowK.H. StieglitzJ. GurvenM.D. ThomasG.S. KaplanH.S. FinchC.E. IrimiaA. Increases in regional brain volume across two native South American male populations.Geroscience20244654563458310.1007/s11357‑024‑01168‑238683289
     [Google Scholar]
  66. TrumbleB.C. CharifsonM. KraftT. GarciaA.R. CummingsD.K. HooperP. LeaA.J. Eid RodriguezD. KoebeleS.V. BuetowK. BeheimB. MinocherR. GutierrezM. ThomasG.S. GatzM. StieglitzJ. FinchC.E. KaplanH. GurvenM. Apolipoprotein-ε 4 is associated with higher fecundity in a natural fertility population.Sci. Adv.2023932eade979710.1126/sciadv.ade979737556539
     [Google Scholar]
  67. TrumbleB.C. StieglitzJ. BlackwellA.D. AllayeeH. BeheimB. FinchC.E. GurvenM. KaplanH. Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden.FASEB J.20173141508151510.1096/fj.201601084R28031319
     [Google Scholar]
  68. JohnstonK. PrestonR. StrivensE. QaloewaiS. LarkinsS. Understandings of dementia in low- and middle-income countries and amongst indigenous peoples: A systematic review and qualitative metasynthesis.Aging Ment. Health 2019.10.1080/13607863.2019.160689131074290
     [Google Scholar]
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History of Senile Dementia from the Antiquity to the Beginning of the Modern Age
Curr Alzheimer Res 22, 502 (2025); https://doi.org/10.2174/0115672050387224250615171055
/content/journals/car/10.2174/0115672050387224250615171055
/content/journals/car/10.2174/0115672050387224250615171055
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  • Article Type:     Review Article
Keyword(s): Alzheimer’s disease; consequence of aging; Dementia; history of dementia; legislative aspects; senile dementia

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