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image of Anthocyanidins Intake is Associated with Alzheimer’s Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018

Abstract

Objective

At present, there is limited research on the association between dietary intake of anthocyanidins and Alzheimer's disease (AD). More epidemiological studies are needed to better understand this relationship.

Methods

We explored the relationship between dietary Anthocyanidins intake and AD among 3806 American adults in the National Health and Nutrition Examination Survey (NHANES) and the United States Department of Agriculture’s Food and Nutrient Database for Dietary Studies (FNDDS) from 2007 to 2010, and 2017 to 2018. We use weighted logistic regression model, restricted cubic spline (RCS) and weighted quantile sum (WQS) regression analysis to analyze the relationship between anthocyanidins monomer and AD.

Results

The weighted logistic regression model showed that the total intake of anthocyanidins was the fourth (OR:0.979; 95% CI: 0.966-0.992) quantile (relative to the lowest quantile) is related to the reduction of AD risk. RCS analysis showed that the total intake of anthocyanidins was negatively linearly correlated with AD (nonlinear value was 0.002). The WQS regression analysis shows that cyanidin and malvidin are the main contributors to the comprehensive effects of six anthocyanidins.

Discussion

Our findings indicate that higher dietary anthocyanin intake may reduce the risk of AD and alleviate neurodegenerative processes. However, the mechanisms underlying this relationship remain unclear. Future studies should confirm these associations and investigate the relevant biological pathways.

Conclusion

Our results show that a higher dietary intake of anthocyanidins is associated with a lower risk of AD.

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2025-05-29
2025-09-11

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Anthocyanidins Intake is Associated with Alzheimer’s Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018
Bentham Science Publishers ; https://doi.org/10.2174/0115672050372100250512054404
/content/journals/car/10.2174/0115672050372100250512054404
/content/journals/car/10.2174/0115672050372100250512054404
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  • Article Type:     Research Article
Keywords: Weighted Quantile Sum ; Food and Nutrient Database for Dietary Studies ; Older ; Anthocyanidins ; Alzheimer's disease ; National Health and Nutrition Examination Survey

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