Current Analytical Chemistry - Online First
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Investigation of Voltametric Behavior and Antioxidant Activity of Vanillin-based Chalcone Compound
Available online: 02 October 2024More LessBackgroundChalcone-type molecules are significant compounds due to their biocompatible properties. This study aimed to examine the electrochemical properties of vanillin chalcone monomer (VC) and its polymer (PANI-VC), as well as to investigate the antioxidant properties of the vanillin chalcone monomer.
MethodsVC and PANI-VC were synthesized and characterized using FTIR and UV-Vis spectroscopy. The electrochemical properties of both compounds were investigated using cyclic voltammetry. The antioxidant activity of the monomer was assessed using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay.
ResultsTwo oxidation peaks and one reduction peak were observed for both the monomer and polymer at pH 3 using cyclic voltammetry in Britton-Robinson buffer solution. The electrochemical oxidation mechanisms of the monomer and polymer were investigated by cyclic voltammetry, and the effects of pH and scan rate were also studied. The electrochemical oxidation mechanism was further evaluated using density functional theory (DFT) computations, revealing that the electrochemical process is adsorption-controlled. The antioxidant activity of VC was assessed using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) method.
ConclusionChalcone-type compounds are known for their potential antioxidant, antimicrobial, antifungal, antibacterial, antiviral, antimalarial, and neuroprotective effects. In this study, the electrochemical properties of the synthesized vanillin chalcone monomer and its polymer were examined, and their electrochemical mechanisms were evaluated through DFT calculations. The antioxidant properties of the monomer were compared to those of ascorbic acid using the DPPH method, revealing that the vanillin chalcone monomer possesses significant antioxidant activity.
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An Efficient and Cost-effective Modified Carbon Paste Electrodes for Diltiazem Hydrochloride Determination in Tablets
Available online: 02 September 2024More LessBackground and ObjectiveThis study presented new sensitive and selective modified carbon paste (MCPE) potentiometric sensors modified with different ion pairs for the determination of the antihypertensive drug diltiazem hydrochloride (DTM-HCl) in biological fluids, pharmaceutical preparations, and in its pure form.
MethodsPlasticizers, ion pair type, ion pair content, response time, temperature, and pH were just a few of the experimental factors evaluated that were found to affect electrode efficiency. The two electrodes that show the best sensitivity were prepared by mixing diltiazem-tetraphenyl borate (DTM-TPB) ion pair, graphite, and TCP or o-NPOE as a plasticizer.
ResultOver the concentration ranges of 1.0x10-5–1.0x10-2, the produced electrodes I and II demonstrated monovalent Nernstian responses of 55.7±0.902 and 57.6±0.451 mV decade-1. The selectivity property of the suggested electrodes was used to study the interference ions. The concentration of DTM-HCl in pharmaceutical formulations and biological fluids was measured using these modified electrodes. During the validation procedure, metrics like linearity, accuracy, precision, limit of detection, limit of quantification, and specificity were used.
ConclusionThe obtained results showed good agreement with the HPLC technique as indicated by the F and t-test values and can conclude the possibility of using this potentiometric method in the routine analysis of DTM-HCl.
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Progress in the Development of Antifouling Electrochemical Biosensors
Authors: Liuxing Chen, Da Chen and Meiling LianAvailable online: 02 September 2024More LessElectrochemical biosensors a subclass of biosensors, consisting of a biosensing element and an electrochemical transducer, have been widely used in various fields due to their excellent performance and portable device. However, in complex actual samples, non-specific adsorption of proteins and solid particles, and adhesion of cells and bacteria will lead to problems such as reduced sensor sensitivity, prolonged response time, and expanded detection errors. Therefore, constructing antifouling sensing platforms to effectively resist the bioadhesion of non-targets is crucial for the performance of biosensors. This study first introduces the commonly used classifications of electrochemical biosensors and their main contaminants. It also provides a comprehensive overview of the construction methods and application research of electrochemical antifouling sensors using different strategies, including the construction of physical, chemical and biological modification interfaces. In addition, the research progress on antifouling and antibacterial dual-action coatings for electrochemical detection is also reviewed. Finally, the challenges and future development trends of various methods are summarized, providing clues for better practical applications of electrochemical biosensors.
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