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Abstract

(Manjishtha), a perennial herb of the Rubiaceae family, has been valued in traditional medicine for its diverse pharmacological properties. Predominantly cultivated in hilly regions, its roots have been historically used for their red pigment and therapeutic applications in Ayurveda. has been traditionally employed for skin diseases, menstrual disorders, snake bites, herpes, eye ailments, haemorrhoids, and fractures. Modern research highlights its potent antioxidant, antimicrobial, and hepatoprotective properties, with evidence supporting its role in managing acne, inflammation, cancer, diabetes, Alzheimer’s disease, and infectious diseases. Furthermore, its integration into various Ayurvedic formulations emphasizes its clinical significance. A comprehensive literature review highlights its bioactive compounds and their therapeutic relevance in modern medicine. The review aims to provide a comprehensive knowledge of the pharmacological impacts, the active components, and the medicinal applications of It uncovers new bioactive compounds, mechanisms of action, or novel formulations, patent protection becomes essential.

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2025-06-20
2025-09-27

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References

  1. Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front. Pharmacol. 2014 4 177 10.3389/fphar.2013.00177 24454289
    [Google Scholar]
  2. Wen M. Chen Q. Chen W. A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications. Front. Pharmacol. 2022 13 965390 10.3389/fphar.2022.965390 36160419
    [Google Scholar]
  3. Li H. Xiao L. Zhang J. Wang H. Han W. Huang Z. Research progress on chemical constituents and pharmacological effects of Rubia cordifolia L. Chin. Tradit. Herbal Drugs 2016 39 06 1433 1436
    [Google Scholar]
  4. Verma A. Kumar B. Alam P. Singh V. Gupta S. Rubia cordifolia – A review on pharmaconosy and phytochemistry. Int. J. Pharm. Sci. Res. 2016 7 2720 2731
    [Google Scholar]
  5. Bhatt P. Kushwah A. Rubia cordifolia overview: A new approach to treat cardiac disorders. J Drug Dev Res 2013 5 47 54
    [Google Scholar]
  6. Sharma P.V. Vijnana DG Chaukhambha Bharati Academy 2011 VOL. II, 341 758 760
    [Google Scholar]
  7. Pathania S. Comparative studies of Rubia cordifolia L. and its commercial samples. Ethnobot. Leafl 2006 1 179 188
    [Google Scholar]
  8. Ali A. Aslam M. Chaudhary S.S. A review on pharmacognostic and therapeutic uses of Rubia cordifolia. J. Drug Deliv. Ther. 2020 10 6 195 202 10.22270/jddt.v10i6.4514
    [Google Scholar]
  9. Joshi V.K. Joshi A. Dhiman K.S. The ayurvedic pharmacopoeia of india, development and perspectives. J. Ethnopharmacol. 2017 197 32 38 10.1016/j.jep.2016.07.030 27404231
    [Google Scholar]
  10. Ojha J.K. Dwivedi K.N. Chaurasiya A.K. Effect of Rubia cordifolia on non healing diabetic foot ulcer Nat Sem Trad Med Plants Skin Care 17 1994
    [Google Scholar]
  11. Gogte V.V.M. Ayurvedic pharmacology and therapeutic uses of medicinal plants. Uttar Pradesh, India Chaukhambha Publications 2009
    [Google Scholar]
  12. Antarkar S.S. Chinwalla T. Bhatt N. Anti-inflammatory activity of Rubia cordifolia Linn. in rats. Int. J. Pharmacol. 1983 15 185 188
    [Google Scholar]
  13. Lodia S. Kansala L. Antioxidant activity of Rubia cordifolia against lead toxicity. Int. J. Pharm. Sci. Res. 2012 3 7 2224 2232
    [Google Scholar]
  14. Tripathi Y.B. Singh A.V. Role of Rubia cordifolia Linn. in radiation protection. Indian J. Exp. Biol. 2007 45 7 620 625 17821858
    [Google Scholar]
  15. Karodi R. Jadhav M. Rub R. Bafna A. Evaluation of the wound healing activity of a crude extract of Rubia cordifolia L. (Indian madder) in mice. Int. J. Appl. Res. Nat. Prod. 2009 2 2 12 18
    [Google Scholar]
  16. Prajapati S.N. Parmar K.A. Anti-viral and in-vitro free radical scavenging activity of leaves of Rubia cordifolia. Int. J. Phytomed. 2011 3 98 107
    [Google Scholar]
  17. Dengre R.G. Patel K.N. Chauhan M.B. Comparative studies of Rubia cordifolia Linn. And Rubia tinctorum Linn (rubiaceae). Anc. Sci. Life 1993 13 1-2 165 179 22556644
    [Google Scholar]
  18. Tripathi Y.B. Shukla S. Sharma M. Shukla V.K. Antioxidant property of Rubia cordifolia extract and its comparison with vitamin E and parabenzoquinone. Phytother. Res. 1995 9 6 440 443 10.1002/ptr.2650090611
    [Google Scholar]
  19. Yusuf M. Shahid M. Khan M.I. Khan S.A. Khan M.A. Mohammad F. Dyeing studies with henna and madder: A research on effect of tin (II) chloride mordant. J. Saudi Chem. Soc. 2012 19 1 64 72 10.1016/j.jscs.2011.12.020
    [Google Scholar]
  20. Dev S. A selection of prime Ayurvedic plant drugs ancient-modern concordance. New Delhi Anamaya Publishers 2006
    [Google Scholar]
  21. Sivarajan V.V. Balachandran I. Ayurvedic drugs and their plant sources. New Delhi Oxford and IBH Publishing 1994
    [Google Scholar]
  22. Adams M. Berset C. Kessler M. Hamburger M. Medicinal herbs for the treatment of rheumatic disorders—A survey of European herbals from the 16th and 17th century. J. Ethnopharmacol. 2009 121 3 343 359 10.1016/j.jep.2008.11.010 19063957
    [Google Scholar]
  23. Patil R. Mohan M. Kasture V. Kasture S. Rubia cordifolia: A review. Orient. Pharm. Exp. Med. 2009 9 1 1 13 10.3742/OPEM.2009.9.1.001
    [Google Scholar]
  24. Zhou C. Jeon T.H. Jun S.H. Kwon J.J. Treatment of 93 cases of damp-heat syndrome (chronic prostatitis) with Tibetan medicine shisanwei ximingwan. Maxillofac. Plast. Reconstr. Surg. 2017 23 08 30 53 10.1186/s40902‑017‑0128‑y 29109943
    [Google Scholar]
  25. Devi P.M. Siril E.A. Traditional and modern use of indian madder (Rubia cordifolia L.): An overview. Int. J. Pharm. Sci. Rev. Res. 2014 25 1 154 164
    [Google Scholar]
  26. Tripathi Y.B. Pandey S. Shukla S.D. Anti-platelet activating factor property of Rubia cordifolia Linn. Indian J. Exp. Biol. 1993 31 6 533 535 8406601
    [Google Scholar]
  27. Padal S.B. Sandhyasri B. Ethnomedicinal investigation of medicinal plants of Sovva panchayat, Dumbriguda Mandalam, Visakhapatnam District, Andhra Pradesh. Int. J. Eng. Sci. 2013 2 55 61
    [Google Scholar]
  28. Gireesha J. Raju N.S. Ethnobotanical study of medicinal plants in BR Hills region of Western Ghats, Karnataka. Asian JPlant Sci Res 2013 3 36 40
    [Google Scholar]
  29. Shilja V.P. Varma K.S. Mohanan K.V. Ethnomedicinal plant knowledge of the Mullu Kuruma tribe of Wayanad district, Kerala. Indian J. Tradit. Knowl. 2008 7 604 612
    [Google Scholar]
  30. Sivaranjani R. Ramakrishnan K.R. Traditional uses of medicinal plants in treating skin diseases in Nagapattina district of Tamil Nadu, India. Int Res J Pharm 2012 3 201 204
    [Google Scholar]
  31. Kapale R. Ethnomedicinal plants used by Baiga tribals in Amarkantak Meikal forest of Madhya Pradesh (India). Bull Environ Pharmacol Life Sci 2012 1 14 15
    [Google Scholar]
  32. Bhosle S.V. Ghule V.P. Aundhe D.J. Jagtap S.D. Ethnomedical knowledge of plants used by the tribal people of Purandhar in Maharashtra. Leafl 2009 13 1353 1361
    [Google Scholar]
  33. BhanuPratap S Dadhich OP. A review study of medicinal uses of manjishtha (Rubia cordifolia). Int. J. Adv. Res. 2017 5 Aug 1394 1401 10.21474/IJAR01/5196
    [Google Scholar]
  34. Singh R. Geetanjali, Chauhan SM. 9,10-Anthraquinones and other biologically active compounds from the genus Rubia. Chem. Biodivers. 2004 1 9 1241 1264 10.1002/cbdv.200490088 17191903
    [Google Scholar]
  35. Kawasaki Y. Goda Y. Yoshihira K. The mutagenic constituents of Rubia tinctorum. Chem. Pharm. Bull. 1992 40 6 1504 1509 10.1248/cpb.40.1504 1394669
    [Google Scholar]
  36. Abdullah S.T. Ali A. Hamid H. Ali M. Ansari S.H. Alam M.S. Two new anthraquinones from the roots of Rubia cordifolia Linn. Pharmazie 2003 58 3 216 217 12685818
    [Google Scholar]
  37. Dosseh C. Tessier A.M. Delaveau P. Rubia cordifolia roots. II: New quinones Planta Med 1981 43 2 141 147 10.1055/s‑2007‑971490 17402026
    [Google Scholar]
  38. Itokawa H. Ibraheim Z.Z. Qiao Y.F. Takeya K. Anthraquinones, naphthohydroquinones and naphthohydroquinone dimers from Rubia cordifolia and their cytotoxic activity. Chem. Pharm. Bull. 1993 41 10 1869 1872 10.1248/cpb.41.1869 8281583
    [Google Scholar]
  39. Son J.K. Jung S.J. Jung J.H. Anticancer constituents from the roots of Rubia cordifolia L. Chem. Pharm. Bull. 2008 56 2 213 216 10.1248/cpb.56.213 18239313
    [Google Scholar]
  40. Cai Y. Sun M. Xing J. Corke H. Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: Structure-radical scavenging activity relationships. J. Agric. Food Chem. 2004 52 26 7884 7890 10.1021/jf0489116 15612771
    [Google Scholar]
  41. Lee J.E. Hitotsuyanagi Y. Kim I.H. Hasuda T. Takeya K. A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: Structure, semi-synthesis, and cytotoxicity. Bioorg. Med. Chem. Lett. 2008 18 2 808 811 10.1016/j.bmcl.2007.11.030 18078747
    [Google Scholar]
  42. Deoda R.S. Kumar D. Bhujbal S.S. Gastroprotective effect of Rubia cordifolia Linn. on aspirin plus pylorus-ligated ulcer. Evid. Based Complement. Alternat. Med. 2011 2011 541624 10.1155/2011/541624
    [Google Scholar]
  43. Deshkar N. Tilloo S. Pande V. A comprehensive review of Rubia cordifolia Linn. Pharm. Rev. 2008 2 3 124
    [Google Scholar]
  44. Gupta R. Gupta B. Phytochemical analysis of Manjishtha (Rubia cordifolia Linn.) and its therapeutic relevance. Pharma Innov. 2017 6 7 164
    [Google Scholar]
  45. Talapatra S.K. Sarkar A.C. Talapatra B. Two pentacyclic triterpenes from Rubia cordifolia. Phytochemistry 1981 20 8 1923 1927 10.1016/0031‑9422(81)84036‑8
    [Google Scholar]
  46. Rao G.M.M. Rao C.V. Pushpangadan P. Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J. Ethnopharmacol. 2006 103 3 484 490 10.1016/j.jep.2005.08.073 16213120
    [Google Scholar]
  47. Gilani A.U.H. Janbaz K.H. Effect of Rubia cordifolia extract on acetaminophen and CCl4‐induced hepatotoxicity. Phytother. Res. 1995 9 5 372 375 10.1002/ptr.2650090513
    [Google Scholar]
  48. Babita M.H. Chhaya G. Goldee P. Hepatoprotective activity of Rubia cordifolia. Pharmacology 2007 3 73 79
    [Google Scholar]
  49. Shilpa P.N. Venkatabalasubramanian S. Devaraj S.N. Ameliorative effect of methanol extract of Rubia cordifolia in N -nitrosodiethylamine-induced hepatocellular carcinoma. Pharm. Biol. 2012 50 3 376 383 10.3109/13880209.2011.608073 22133091
    [Google Scholar]
  50. Siddique A. Gaur A. Bajpai A. John A. Evaluation of hepatoprotective potential of rubia cordifolia in experimentally (carbon tetrachloride) induced hepatotoxicity in albino rats. Int. J. Health Sci. 2022 6 S4 804 814 10.53730/ijhs.v6nS4.5708
    [Google Scholar]
  51. Chitra V. Raju D.S. Kumar K.P. Neuroprotective studies of Rubia cordifolia Linn. on β-amyloid induced cognitive dysfunction in mice. Int. J. Pharm. Tech. Res. 2009 1 1000 1009
    [Google Scholar]
  52. Prabhakara S. Anbazhagan K. Chandrashekar B.S. Characterization of Rubia cordifolia L. root extract and its evaluation of cardioprotective effect in Wistar rat model. Indian J. Pharmacol. 2018 50 1 12 21 10.4103/ijp.IJP_418_17 29861523
    [Google Scholar]
  53. Kumari P. Sharma S.K. Tiwari S. Evaluation of antihyperlipidemic and antioxidant activity of Rubia cordifolia Linn. J. Drug Deliv. Ther. 2019 9 1 211 215 10.22270/jddt.v9i1.2216
    [Google Scholar]
  54. Chen Y. Chen P.D. Bao B.H. Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish. J. Ethnopharmacol. 2018 219 152 160 10.1016/j.jep.2017.11.005 29126989
    [Google Scholar]
  55. Khan M.S. Aziz S. Khan M.Z. Antihyperglycemic effect and phytochemical investigation of Rubia cordifolia (Indian Madder) leaves extract. Open Chem. 2021 19 1 586 599 10.1515/chem‑2021‑0053
    [Google Scholar]
  56. Somani S.R. Jain S.K. Singhai A.K. Hypoglycaemic activity of roots of Rubia cordifolia in normal and diabetic rats. Pharmacol 2007 1 162 169
    [Google Scholar]
  57. Kalra P. Sharma S. Datusalia A.K. Antiulcer potential of Rubia cordifolia Linn. in experimental animals. Int J Green Pharm 2011 5 2 149 154 10.4103/0973‑8258.85182
    [Google Scholar]
  58. Pawar A.T. Ghodasara J.V. Anap R.M. Kuchekar B.S. Protective effect of hydroalcoholic root extract of Rubia cordifolia in indomethacin-induced enterocolitis in rats. Indian J. Pharm. Sci. 2011 73 2 250 253 10.4103/0250‑474X.91577 22303076
    [Google Scholar]
  59. Nair C.K.K. Joy J. Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract. J. Cancer Res. Ther. 2008 4 3 111 115 10.4103/0973‑1482.43139 18923202
    [Google Scholar]
  60. lodi S, Sharma V, Kansal L. The protective effect of Rubia cordifolia against lead nitrate-induced immune response impairment and kidney oxidative damage. Indian J. Pharmacol. 2011 43 4 441 444 10.4103/0253‑7613.83118 21845002
    [Google Scholar]
  61. Kasture S. Kasture V. Chopde C. Anti-inflammatory activity of Rubia cordifolia roots. J. Nat. Rem. 2001 1 111 115 10.18311/jnr/2001/17
    [Google Scholar]
  62. Patel A. Patel T. Macwan C. Patel M. Chauhan K. Patel J. Evaluation of anti inflammatory and analgesic activity of roots of Rubia cordifolia in rats. J Pharm Sci Res 2010 2 12 809 813
    [Google Scholar]
  63. Basu S. Ghosh A. Hazra B. Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: Isolation of emodin and physcion as active antibacterial agents. Phytother. Res. 2005 19 10 888 894 10.1002/ptr.1752 16261521
    [Google Scholar]
  64. Adwankar M.K. Chitnis M.P. In vivo anti-cancer activity of RC-18: A plant isolate from Rubia cordifolia, Linn. against a spectrum of experimental tumour models. Chemotherapy 1982 28 4 291 293 10.1159/000238092 7116981
    [Google Scholar]
  65. Jun D.Y. Han C.R. Lee J.Y. Anti-adipogenic activity of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone from Rubia cordifolia L. J. Med. Food 2011 14 5 454 461 10.1089/jmf.2010.1385 21434777
    [Google Scholar]
  66. Nam W. Nam S.H. Kim S.P. Levin C. Friedman M. Anti-adipogenic and anti-obesity activities of purpurin in 3T3-L1 preadipocyte cells and in mice fed a high-fat diet. BMC Complement. Altern. Med. 2019 19 1 364 10.1186/s12906‑019‑2756‑5 31829180
    [Google Scholar]
  67. Pawar A.T. Kalyani D. Chandrasekar S.B. Divakar G. Diuretic activity of root extract of Rubia cordifolia. Pharmacol 2009 1 597 603
    [Google Scholar]
  68. Shilpa P.N. Sivaramakrishnan V. Devaraj S.N. Induction of apoptosis by methanolic extract of Rubia cordifolia Linn in HEp-2 cell line is mediated by reactive oxygen species. Asian Pac. J. Cancer Prev. 2012 13 6 2753 2758 10.7314/APJCP.2012.13.6.2753 22938454
    [Google Scholar]
  69. Lee J.H. Kim N.W. Her E. Rubiae Radix suppresses the activation of mast cells through the inhibition of Syk kinase for anti-allergic activity. J. Pharm. Pharmacol. 2006 58 4 503 512 10.1211/jpp.58.4.0010 16597368
    [Google Scholar]
  70. Zhu Z.G. Jin H. Yu P.J. Tian Y.X. Zhang J.J. Wu S.G. Mollugin inhibits the inflammatory response in lipopolysaccharide-stimulated RAW264.7 macrophages by blocking the Janus kinase-signal transducers and activators of transcription signaling pathway. Biol. Pharm. Bull. 2013 36 3 399 406 10.1248/bpb.b12‑00804 23318249
    [Google Scholar]
  71. Ghosh S. Das Sarma M. Patra A. Hazra B. Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. J. Pharm. Pharmacol. 2010 62 9 1158 1166 10.1111/j.2042‑7158.2010.01151.x 20796195
    [Google Scholar]
  72. Nautiyal C.S. Rawat A.K.S. Ojha S.K. Rao C.V. Mani D. Pal A. Kumar D. A synergistic herbal composition useful for the management of diabetes Patent WO2015189858A1 2023
    [Google Scholar]
/content/journals/biot/10.2174/0118722083359338250611055647
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Unveiling the Modern Therapeutic Properties and Folk Medicinal Riches of Rubia cordifolia
Bentham Science Publishers ; https://doi.org/10.2174/0118722083359338250611055647
/content/journals/biot/10.2174/0118722083359338250611055647
/content/journals/biot/10.2174/0118722083359338250611055647
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  • Article Type:     Review Article
Keywords: Rubia cordifolia ; modern medicine ; pharmacological properties ; therapeutic applications ; bioactive compounds ; hepatoprotective properties

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