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image of Exploring the Two-Way Role: Biological and Anti-Epileptic 
Properties of Imidazole and 2-Mercaptobenzimidazole Derivatives

Abstract

Imidazole and 2-mercapto benzimidazole analogues are a group of molecules that have various biological activities and good therapeutic potential in the treatment of epilepsy. This review explores their dual role, focusing on their biological properties and anti-epileptic effects. A spectrum of biological activities is displayed by imidazole derivatives and 2- mercaptobenzimidazole, such as antifungal, antioxidant, anti-inflammatory, and antimicrobial actions, leading to their therapeutic flexibility apart from epilepsy treatment. Imidazole derivatives mechanistically modulate Gamma-Aminobutyric Acid (GABA) receptors, inhibit ion channels, and exert neuroprotective effects, enabling them to be used for seizure control. Their mechanisms of action involve modulation of oxidative stress pathways as well as providing neuroprotective effects against epilepsy. In terms of structure, both imidazole and 2-mercaptobenzimidazole derivatives have gone through extensive structure-activity relationship studies to enhance their biological and pharmacological aspects. However, numerous concerns, such as bioavailability, selectivity, and side effects, hinder their effective application in the treatment of various diseases. Looking forward, further research into novel derivatives and patented formulation strategies holds promise for enhancing efficacy and reducing adverse effects. This review consolidates current knowledge, emphasizing the multifaceted roles of imidazole and 2-mercapto benzimidazole derivatives in biological systems and their potential as anti-epileptic agents, thus providing insights for future research and clinical applications.

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2025-04-25
2025-09-27

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/content/journals/biot/10.2174/0118722083345879250403115017
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Exploring the Two-Way Role: Biological and Anti-Epileptic 
Properties of Imidazole and 2-Mercaptobenzimidazole Derivatives
Bentham Science Publishers ; https://doi.org/10.2174/0118722083345879250403115017
/content/journals/biot/10.2174/0118722083345879250403115017
/content/journals/biot/10.2174/0118722083345879250403115017
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  • Article Type:     Review Article
Keywords: seizure ; Imidazole ; epilepsy ; 2-mercapto benzimidazole ; anti-epileptic agent ; biological activities ; anti-inflammatory ; antioxidant ; antifungal ; neuroprotection ; antimicrobial ; GABA receptors

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