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2000
Volume 20, Issue 1
  • ISSN: 1872-2083
  • E-ISSN: 2212-4012

Abstract

Background

Among the bioactive isoflavones identified from different plants is formononetin. Formononetin's antioxidant, anti-inflammatory, and anti-cancer qualities have all received a lot of attention lately. The goal of the current investigation was to examine formononetin's antifungal and antibacterial activity against and , respectively.

Methods

The present study determined the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and Minimum Fungicidal Concentration (MFC) of formononetin, chlorhexidine, formononetin + chlorhexidine, Formononetin + nystatin, and nystatin against and isolates. Next, SPSS version 25 was used to analyze the data. A significance cutoff of 0.05 was taken into account.

Results

Chlorhexidine + formononetin and formononetin alone had the greatest and lowest minimum inhibitory concentrations (MIC) against , at 6.6 and 18.3 μg/ml, respectively. With MIC values of 0.66 and 8.3 μg/ml against a isolate sensitive to nystatin, the combination of formononetin + nystatin and formononetin alone was shown to have the greatest and lowest anti-candida effects.

Conclusion

The findings demonstrated a considerably greater antibacterial effect (0.05) for the combinations of formononetin + nystatin and chlorhexidine as compared to nystatin and chlorhexidine alone.

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Antimicrobial Effect of Formononetin Against the Periodontal Pathogens Enterococcus faecalis and Candida albicans
Recent Pat. Biotechnol. 20, 149 (2026); https://doi.org/10.2174/0118722083342082241129060918
/content/journals/biot/10.2174/0118722083342082241129060918
/content/journals/biot/10.2174/0118722083342082241129060918
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  • Article Type:     Research Article
Keyword(s): Antimicrobial effects; formononetin; minimum bactericidal concentration; minimum fungicidal concentration; minimum inhibitory concentration; nystatin

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