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image of In Situ Gelling Systems for the Treatment of Ocular Pain and Inflammation: A Review

Abstract

Ocular drug delivery presents significant challenges due to the intricate anatomy and protective barriers of the eye, which limit drug penetration and retention. Addressing common issues like ocular pain and inflammation, conditions that substantially impact the quality of life, requires innovative approaches. This review focuses on gel systems as a promising solution for ocular drug delivery, specifically for managing pain and inflammation. gels, which transition from liquid to gel upon contact with the eye, offer distinct advantages over traditional formulations, such as prolonged residence time, sustained drug release, enhanced drug retention, and minimized systemic side effects. These benefits contribute to enhanced therapeutic efficacy and increased patient comfort. It also examines various polymers and gelling mechanisms used in gels, including temperature-sensitive, pH-sensitive, and ion-activated polymers. While there is significant promise in the development of gel systems, several challenges must be addressed, including the optimization of viscosity, the assurance of biocompatibility, and the precise adjustment of drug release profiles. Future research is geared toward integrating novel polymers, designing stimuli-responsive systems, and advancing targeted drug delivery strategies. These innovations aim to further improve the effectiveness and patient compliance of gel systems for ocular applications, offering a viable alternative for sustained and comfortable management of ocular pain and inflammation.

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2025-02-26
2025-03-25

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/content/journals/aia/10.2174/0122113525361929250127060448
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In Situ Gelling Systems for the Treatment of Ocular Pain and Inflammation: A Review
Bentham Science Publishers ; https://doi.org/10.2174/0122113525361929250127060448
/content/journals/aia/10.2174/0122113525361929250127060448
/content/journals/aia/10.2174/0122113525361929250127060448
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  • Article Type:     Review Article
Keywords: ocular pain ; hydrogels ; ocular inflammation ; biodegradable polymers ; drug delivery ; In situ gels

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