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2000
Volume 25, Issue 16
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

With the development of herbal medicine, more and more chemical extracts isolated from natural herbs are being used to treat cancer, and herbal monomers play an important role in treating tumors. There is no doubt that these substances have a powerful ability to address the growing incidence of cancer. Among them, Trigonelline, due to its anti-tumor, hypoglycemic, hypolipidemic, antioxidant, and aphrodisiac properties, has been comprehensively studied for its therapeutic potential. However, there is a lack of a complete and specific review of Trigonelline research. Regarding the information mentioned before, this paper summarizes and describes the literature related to the response mechanisms and therapeutic potential of Trigonelline. This review describes the effects of Trigonelline in inhibiting tumor growth and metastasis, reducing the toxicity of chemotherapeutic agents, decreasing oxidative stress, increasing the sensitivity type of chemotherapeutic agents, and reversing drug resistance. On account of the merits of low cost, safety and efficacy, and few toxic side effects, Trigonelline has the potential to become a new and valuable drug. Furthermore, the in-depth study of this natural substance is yet to be further developed. In addition, by exploiting it more extensively, it is expected to be an effective addition to cancer treatment. We can expect that in the future more and more herbal extracts can be used in clinical practice to prolong the survival and improve the quality of life of patients.

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2025-09-06

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/content/journals/acamc/10.2174/0118715206363456250226061713
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Unveiling the Therapeutic Potential of Trigonelline: A Promising Approach in Cancer Prevention and Treatment
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 25, 1175 (2025); https://doi.org/10.2174/0118715206363456250226061713
/content/journals/acamc/10.2174/0118715206363456250226061713
/content/journals/acamc/10.2174/0118715206363456250226061713
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  • Article Type:     Review Article
Keyword(s): cancer; chinese medicine; herbal medicine; inhibit; mechanism; Trigonelline

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