Protocol for Silicone Oil-Induced Ocular Hypertension
- Authors: Alyssa Hostert1, Sunny E. Ohia2, Ya Fatou Njie Mbye3, Catherine A. Opere4
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View Affiliations Hide Affiliations1 Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA 2 Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA 3 Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA 4 Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA
- Source: Research Protocols for Ophthalmic Disease Mechanisms and Therapeutics: Glaucoma - Ocular Hypertension , pp 315-319
- Publication Date: August 2025
- Language: English
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This chapter describes the protocols to induce ocular hypertension in rabbits using silicone oil. This process consists of many steps and sub-steps, including preparation of the animal for anesthesia, preparation of materials, administration of anesthesia, preparation for silicone oil (SO) injection, intracameral injection of SO, and finally, postoperative care. Healthy animals free of ocular morphological abnormalities or disease states should be chosen for inclusion before beginning the protocol. Following these steps will allow for the simulation of ocular hypertension while also ensuring an aseptic environment.
Hardbound ISBN:
9789815324341
Ebook ISBN:
9789815324334
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