Nanoformulations to Limit Challenges of Conventional Therapy Against Hepatocellular Carcinoma-An Overview

- Authors: Suresh Ajmeera1, V. Badireenath Konkimalla2
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View Affiliations Hide AffiliationsAffiliations: 1 School of Biological Sciences, National Institute of Science Education and Research, HBNI,Khordha, Jatni, Odisha 752050, India 2 School of Biological Sciences, National Institute of Science Education and Research, HBNI,Khordha, Jatni, Odisha 752050, India
- Source: Nanotherapeutics for the Treatment of Hepatocellular Carcinoma , pp 166-218
- Publication Date: March 2022
- Language: English
The chapter primarily deals with different nano-drug delivery approaches to overcome current HCC chemotherapy challenges. The objective of organizing the various sections in this chapter is to highlight the different nanoformulations that are currently being explored, benefits of nanoformulations over the free drug, different approaches and molecular blocks utilized for preparation on different nanoformulations and their applications in the context of the development of novel drug delivery approaches in HCC. Conventional chemotherapy and its limitations for HCC, different targeting approaches for HCC, need for nanoparticulate approach in HCC, different strategies for delivery of nanoformulations with different targeting approaches, different nanoformulations (liposomes, micelles, hydrogels, etc.) that are currently studied in HCC, different molecular blocks under preparation, the current status of clinical trials of different nanoformulations studied for HCC therapy and perspective for futuristic role of nanoformulations in HCC have been discussed in the present chapter.
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