Nanoformulations to Limit Challenges of Conventional Therapy Against Hepatocellular Carcinoma – An Overview

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The chapter primarily deals with different nano-drug delivery approaches toovercome current HCC chemotherapy challenges. The objective of organizing thevarious sections in this chapter is to highlight the different nanoformulations that arecurrently being explored, benefits of nanoformulations over the free drug, differentapproaches and molecular blocks utilized for preparation on different nanoformulationsand their applications in the context of the development of novel drug deliveryapproaches in HCC. Conventional chemotherapy and its limitations for HCC, differenttargeting approaches for HCC, need for nanoparticulate approach in HCC, differentstrategies for delivery of nanoformulations with different targeting approaches,different nanoformulations (liposomes, micelles, hydrogels, etc.) that are currentlystudied in HCC, different molecular blocks under preparation, the current status ofclinical trials of different nanoformulations studied for HCC therapy and perspectivefor futuristic role of nanoformulations in HCC have been discussed in the presentchapter.