From Cells to Clinic - Direct Biomolecule Quantification of Clinically Relevant Biomolecules

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<div>Translation of investigative cellular analysis into reliable clinical settings is</div><div>a challenge and surface enhanced Raman spectroscopic (SERS) technique has the</div><div>potential to move beyond laboratorial examinations. Quantitative and qualitative</div><div>measurement of cellular components and their properties is essential indicative of</div><div>healthy or disease state. Pre-emptive analysis of diseased state offers synchronization</div><div>with early diagnosis of certain medical conditions and is requisite for initiation of</div><div>therapeutic interventions. High sensitivity and capacity for multiplexing renders SERS</div><div>suitable for biochemical analysis for disease diagnosis a critical step towards</div><div>formulation of therapeutic regime. SERS assists in a deeper understanding of cellular</div><div>processes and its micro environment without disturbing and damaging the cellular</div><div>milieu in 3 dimensional (3D) set up without invading the tissues. Fabrication of novel</div><div>nanostructures with enhanced plasmonic effects has also propelled the growth of SERS</div><div>based analysis of cellular structure in normal and abnormal circumstances. Thus, SERS</div><div>is operating as diagnostic tool for in-vitro, ex-vivo and in-vivo investigations for</div><div>assessing onset of disease as well as prognosis of the therapy in hospitals and clinics.</div>