Cardiac Intracellular Renin-Angiotensin System
- Authors: Rajesh Kumar1, Kenneth M. Baker2, Wen Chen3, Larissa Miranda Pereira4, Candice M. Thomas5, Qian Chen Yong6
-
View Affiliations Hide Affiliations1 1901 South First Street, Building 205 Temple , Texas 76504 2 1901 South First Street, Building 205 Temple , Texas 76504 3 1901 South First Street, Building 205 Temple , Texas 76504 4 1901 South First Street, Building 205 Temple , Texas 76504 5 1901 South First Street, Building 205 Temple , Texas 76504 6 1901 South First Street, Building 205 Temple , Texas 76504
- Source: New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases , pp 79-91
- Publication Date: November 2016
- Language: English
Cardiac Intracellular Renin-Angiotensin System, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9781681083131/chapter-4-1.gif
As a hormonal system, the renin-angiotensin system (RAS) is known for endocrine and autocrine/paracrine physiological functions. An intracrine role of the RAS has been proposed long ago; however, evidence for this function has started accumulating only recently. Angiotensin (Ang) II is the major hormone of the RAS and is the focus of research for the intracrine nature of this system. The intracrine functionality is characterized by intracellular actions of the hormone within the cell of synthesis or following internalization. Intracellular synthesis and actions of Ang II have been demonstrated in several cell types and tissues, with a significant amount of work in the heart. This review focuses on the cardiac intracellular RAS, delineating differences from the extracellular RAS that further consists of the circulatory and local RASs. The pathophysiological significance of the intracellular cardiac RAS has been discussed.
-
From This Site
/content/books/9781681083131.chapter-4dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
