Bentham Science Publishers

This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic, and immune disorders which are linked to oxidative stress-mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs that aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them.

5 chapters elucidate the free radical biology of the diseases.

1. Role of free radical biology in diabetes mellitus

2. Role of GSK3 in the regulation of insulin release and glucose metabolism

3. Regulatory role of NRF2 in rheumatoid arthritis

4. Role of free radical biology in Alzheimer's disease

5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis Key features:

- Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases

- Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis

- Covers the role of free radicals in Alzheimer's disease and new interventions that target mitochondrial mechanisms

- Systematically explains the molecular biology of free radicals with the help of schematic diagrams

- Includes references for further reading The accessible and structured text in this reference makes it a suitable resource for all biomedical scientists, faculty, and postgraduate students in academia and industry.

Most findings about molecular interactions and cellular regulatory events are published in peer-reviewed scientific literature in the form of scientific jargon. The computerized text-mining algorithms are used to convert free grammar of human language into a set of formalized relationships between biological concepts in order to use this wealth of information. The compendium of such interactions extracted from an entire set of biomedical literature is a called knowledge network. Knowledge networks are the first step in the process of digitizing molecular biological knowledge. The next step is building molecular models depicting principal molecular events that govern various biological processes. Data mining in knowledge networks is the essence of building new biological models. The purpose is to elucidate major pathways of information flow through a molecular physical interaction network that happens during a disease, a cell process or an experiment. Such models contain key proteins involved in the process and can be used for prioritizing disease targets, for understanding of drug action and prevention of drug-induced toxicities, for analysis of patient predispositions and design of personalized therapies, for design of diagnostic biomarkers and analysis of patient molecular data. This e-book contains detailed examples illustrating the path to the digital biology and computerized drug development for personalized medicine. It provides conceptual principals for building biological models and for applying the models to make predictions relevant for drug development and translational medicine.

The e-book will also be useful for researchers who use high-throughput technologies for molecular profiling of disease and drug action. It provides examples for analysis of gene expression microarrays to infer biological models, to find biomarkers for drug response and for applications of high-throughput molecular profiling technologies for personalized medicine. Scientists in academia, in pharmaceutical industry as well as graduate students will benefit from reading this book. The illustrations from the book can also be readily used in taught courses for molecular biology and pharmacology.

Genetic Diversity of Coronaviruses (Volume 1) provides a comprehensive analysis of the genetic mutations and host interactions across three major coronaviruses—SARS-CoV, MERS-CoV, and SARS-CoV-2. This volume explores the evolutionary history, mutations, and emerging variants of these viruses, with a focus on understanding how they adapt to different hosts. The book is organized into three parts: Part I covers SARS-CoV, detailing its genetic mutations, host genetic diversity, and new variants. Part II focuses on MERS-CoV, offering insights into mutations and host adaptations. Part III addresses SARS-CoV-2, discussing its evolving variants and the role of host proteins. The book also discusses the connections between coronaviruses and neurological, epigenetic, and AI-related issues.

Key Features:

- In-depth analysis of genetic mutations in coronaviruses.

- Exploration of host genetic diversity and virus adaptation.

- Insight into emerging variants of SARS-CoV, MERS-CoV, and SARS-CoV-2.

- Examination of host proteins' role in viral infections.

- Discussion on the impact of AI and epigenetics on coronavirus research.

Menopause is a significant milestone in a woman's life, marking the end of fertility and the start of a new phase. However, it can also bring many physical and emotional symptoms, such as hot flashes, mood changes, and a higher risk of osteoporosis and heart disease. Because of these issues, dealing with menopause can be a challenge.

From Taboo to Wellness: The Facts behind Menopause is an informative guide to menopause. It provides clarity and accessibility for anyone interested in understanding the topic, and wants to deconstruct any myths that surround it with facts. From symptoms to treatments, this book covers everything you need to know about menopause in an engaging and easy-to-understand way.

Written with the general reader in mind, this book explores the science behind menopause, as well as the male andropause and how it differs from the female experience. With insights into Hormone Replacement Therapy (HRT) and future treatments using stem cells, it gives a comprehensive understanding of the options for managing menopause. But that's not all - the book also delves into the fascinating world of menopause in the animal kingdom, offering a unique perspective on how different species experience hormonal changes caused by this life-changing event.

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry,in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The tenth volume of the series features chapters covering the following topics:

- Challenges in the Management of Hepatoblastoma

- The Emerging Role of Monocarboxylate Transporter-1 in Cancer

- In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery

- Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers

- Polyphenols and Cancer

- Glioblastoma Multiforme

- Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

This volume of the series focuses on reviews of treatments derived from natural sources (cannabinoid-based medicines and turmeric), immunotherapy, biomarkers for glioblastoma and some new drug targets for anti-cancer treatment.

The reviews included in this volume are:

- Cannabinoid-Based Anticancer Strategies:

- The Beneficial Effects of Turmeric and Its Active Constituent in Cancer Treatment

- Immunotherapy Approaches Focusing on Cancer Stem Cells

- Immunotherapy for the Treatment of Hepatocellular Carcinoma

- Role of Biomarkers in Developing Therapies for Glioblastoma Multiforme

- Poly (ADP-ribose) Polymerases as New Drug Targets in Cancer Treatment

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading for all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

"Frontiers in Anti-Cancer Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The fifth volume of the series features chapters on the following topics:

-Nutraceuticals and natural food products for cancer treatment

-Pharmacogenomics in Anti-cancer treatment

-Cancer stem cells

-Potassium channel targeting for brain tumor treatment

-Sorafenib in the management of hepatocellular carcinoma

…and more.

Frontiers in Anti-Cancer Drug Discovery is an eBook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

The seventh volume of the series features chapters covering the following topics:

- Malignant pleural mesothelioma

- Colorectal cancer therapy

- Drugs for treating pancreatic cancer

- Adjuvant endocrine therapy for early breast cancer

- Cyclin E and its potential use for liver cancer prognosis and therapy