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2000
Volume 20, Issue 3
  • ISSN: 1574-8928
  • E-ISSN: 2212-3970

Abstract

Background

miR-1468-5p, a type of microRNA, is acknowledged for its crucial involvement in a variety of cancerous processes. Nonetheless, the specific impact of this microRNA on lung adenocarcinoma (LUAD) has not yet been clearly defined.

Objective

Our aim was to investigate how miR-1468-5p influences LUAD.

Methods

The Cancer Genome Atlas (TCGA) offered specimens for our research. Employing statistical techniques, we assessed the diagnostic and prognostic significance of miR-1468-5p, as well as its association with clinical characteristics. Our analysis delved into the target genes and the regulatory mechanisms influenced by miR-1468-5p. The expression levels of miR-1468-5p in LUAD cell lines were validated through quantitative reverse transcription polymerase chain reaction (qRT-PCR).

Results

The expression of miR-1468-5p varied significantly across different cancer types. The presence of reduced miR-1468-5p levels was correlated with a lower likelihood of overall survival in LUAD patients, with a statistically significant result ( = 0.005). miR-1468-5p demonstrated independent prognostic significance in LUAD and potentially contributes to disease progression multiple pathways, including the HIF-1 signaling pathway and more. There was a significant reduction in miR-1468-5p expression in LUAD cell lines when compared to cells of the normal lung epithelium.

Conclusion

miR-1468-5p may serve as a useful patent as a therapeutic intervention target and a prognostic indicator for LUAD patients.

© 2025 Bentham Science Publishers
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Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma
Recent Patents on Anti-Cancer Drug Discovery 20, 354 (2025); https://doi.org/10.2174/0115748928344326240927071620
/content/journals/pra/10.2174/0115748928344326240927071620
/content/journals/pra/10.2174/0115748928344326240927071620
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  • Article Type:     Research Article
Keyword(s): biomarker; HIF-1 signaling pathway; lung adenocarcinoma; microRNA-1468-5p; prognosis; therapeutic target

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