Skip to content
2000
image of Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma

Abstract

Background

miR-1468-5p, a type of microRNA, is acknowledged for its crucial involvement in a variety of cancerous processes. Nonetheless, the specific impact of this microRNA on lung adenocarcinoma (LUAD) has not yet been clearly defined.

Objective

Our aim was to investigate how miR-1468-5p influences LUAD.

Methods

The Cancer Genome Atlas (TCGA) offered specimens for our research. Employing statistical techniques, we assessed the diagnostic and prognostic significance of miR-1468-5p, as well as its association with clinical characteristics. Our analysis delved into the target genes and the regulatory mechanisms influenced by miR-1468-5p. The expression levels of miR-1468-5p in LUAD cell lines were validated through quantitative reverse transcription polymerase chain reaction (qRT-PCR).

Results

The expression of miR-1468-5p varied significantly across different cancer types. The presence of reduced miR-1468-5p levels was correlated with a lower likelihood of overall survival in LUAD patients, with a statistically significant result ( = 0.005). miR-1468-5p demonstrated independent prognostic significance in LUAD and potentially contributes to disease progression multiple pathways, including the HIF-1 signaling pathway and more. There was a significant reduction in miR-1468-5p expression in LUAD cell lines when compared to cells of the normal lung epithelium.

Conclusion

miR-1468-5p may serve as a useful patent as a therapeutic intervention target and a prognostic indicator for LUAD patients.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/pra/10.2174/0115748928344326240927071620
2025-02-03
2025-09-12

  • From This Site

    /content/journals/pra/10.2174/0115748928344326240927071620
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Avancini A. Sartori G. Gkountakos A. Casali M. Trestini I. Tregnago D. Bria E. Jones L.W. Milella M. Lanza M. Pilotto S. Physical activity and exercise in lung cancer care: Will promises be fulfilled? Oncologist 2020 25 3 e555 e569 10.1634/theoncologist.2019‑0463 32162811
    [Google Scholar]
  2. Liang R. Li X. Li W. Zhu X. Li C. DNA methylation in lung cancer patients: Opening a "window of life" under precision medicine. Biomed Pharmacother. 2021 144 112202
    [Google Scholar]
  3. Wang Z. Guan W. Ma Y. Zhou X. Song G. Wei J. Wang C. MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway. BMC Cancer 2023 23 1 668 10.1186/s12885‑023‑11113‑9 37460940
    [Google Scholar]
  4. Qiang H. Zhan X. Wang W. Cheng Z. Ma S. Jiang C. A study on the correlations of the miR-31 expression with the pathogenesis and prognosis of head and neck squamous cell carcinoma. Cancer Biother. Radiopharm. 2019 34 3 189 195 10.1089/cbr.2018.2621 30628842
    [Google Scholar]
  5. Lu S. Zhou C. Zou B. Zhang H. Feng M. MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1. Genes Immun. 2020 21 1 4 12 10.1038/s41435‑019‑0081‑0 31118494
    [Google Scholar]
  6. Zhang X.J. Jin Y. Song J.L. Deng F. MiR-373 promotes proliferation and metastasis of oral squamous cell carcinoma by targeting SPOP. Eur. Rev. Med. Pharmacol. Sci. 2019 23 12 5270 5276 31298378
    [Google Scholar]
  7. Tang L. Yuan Y. Zhai H. Wang J. Zhang D. Liang H. Shi Y. Duan L. Jiang X. MicroRNA-125b-5p correlates with prognosis and lung adenocarcinoma progression. Front. Mol. Biosci. 2022 8 788690 10.3389/fmolb.2021.788690 35187068
    [Google Scholar]
  8. Lin Z. Huang W. Xie Z. Yi Y. Li Z. Expression, clinical significance, immune infiltration, and regulation network of miR-3940-5p in lung adenocarcinoma based on bioinformatic analysis and experimental validation. Int. J. Gen. Med. 2022 15 6451 6464 10.2147/IJGM.S375761 35966511
    [Google Scholar]
  9. Jiang X. Yuan Y. Tang L. Wang J. Zhang D. Cho W.C. Duan L. Identification and validation prognostic impact of MiRNA-30a-5p in lung adenocarcinoma. Front. Oncol. 2022 12 831997 10.3389/fonc.2022.831997 35127546
    [Google Scholar]
  10. Jiang K. Zhi T. Xu W. Xu X. Wu W. Yu T. Nie E. Zhou X. Bao Z. Jin X. Zhang J. Wang Y. Liu N. MicroRNA-1468-5p inhibits glioma cell proliferation and induces cell cycle arrest by targeting RRM1. Am. J. Cancer Res. 2017 7 4 784 800 28469953
    [Google Scholar]
  11. Sanchez V. Golyardi F. Mayaki D. Echavarria R. Harel S. Xia J. Hussain S.N.A. Negative regulation of angiogenesis by novel micro RNAs. Pharmacol. Res. 2019 139 173 181 10.1016/j.phrs.2018.11.010 30414893
    [Google Scholar]
  12. Zhou C Wei W Ma J Yang Y Liang L Zhang Y Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels. Mol Ther. 2021 29 4 1512 1528 10.1016/j.ymthe.2020.12.034
    [Google Scholar]
  13. Yang D. Liu M. Jiang J. Luo Y. Wang Y. Chen H. Li D. Wang D. Yang Z. Chen H. Comprehensive Analysis of DMRT3 as a Potential Biomarker Associated with the Immune Infiltration in a Pan-Cancer Analysis and Validation in Lung Adenocarcinoma. Cancers (Basel) 2022 14 24 6220 10.3390/cancers14246220 36551704
    [Google Scholar]
  14. Han Q. Cui Z. Wang Q. Pang F. Li D. Wang D. Upregulation of OTX2-AS1 is Associated With Immune Infiltration and Predicts Prognosis of Gastric Cancer. Technol. Cancer Res. Treat. 2023 22 10.1177/15330338231154091 36740995
    [Google Scholar]
  15. Liang W. Lu Y. Pan X. Zeng Y. Zheng W. Li Y. Nie Y. Li D. Wang D. Decreased Expression of a Novel lncRNA FAM181A-AS1 is Associated with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma. Pharm. Genomics Pers. Med. 2022 15 985 998 10.2147/PGPM.S384901 36482943
    [Google Scholar]
  16. Lyu G. Bioinformatic Analysis and Experimental Validation of HMGA2-AS1 as a Prognostic Biomarker Associated with Immune Infiltration in Gastric Cancer. Recent Patents Anticancer Drug Discov. 2024 19 Epub ahead of print 10.2174/0115748928284459240318070914 38566377
    [Google Scholar]
  17. Miao L. Chen B. Jing L. Zeng T. Chen Y. TPD52 as a Potential Prognostic Biomarker and its Correlation with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma: Bioinformatic Analysis and Experimental Verification. Recent Patents Anticancer Drug Discov. 2024 19 Epub ahead of print 10.2174/0115748928267447231107101539 38305309
    [Google Scholar]
  18. Lu X. Jing L. Liu S. Wang H. Chen B. miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma. Int. J. Endocrinol. 2022 2022 1 15 10.1155/2022/5006123 35719192
    [Google Scholar]
  19. Liu J. Lichtenberg T. Hoadley K.A. Poisson L.M. Lazar A.J. Cherniack A.D. Kovatich A.J. Benz C.C. Levine D.A. Lee A.V. Omberg L. Wolf D.M. Shriver C.D. Thorsson V. Hu H. Caesar-Johnson S.J. Demchok J.A. Felau I. Kasapi M. Ferguson M.L. Hutter C.M. Sofia H.J. Tarnuzzer R. Wang Z. Yang L. Zenklusen J.C. Zhang J.J. Chudamani S. Liu J. Lolla L. Naresh R. Pihl T. Sun Q. Wan Y. Wu Y. Cho J. DeFreitas T. Frazer S. Gehlenborg N. Getz G. Heiman D.I. Kim J. Lawrence M.S. Lin P. Meier S. Noble M.S. Saksena G. Voet D. Zhang H. Bernard B. Chambwe N. Dhankani V. Knijnenburg T. Kramer R. Leinonen K. Liu Y. Miller M. Reynolds S. Shmulevich I. Thorsson V. Zhang W. Akbani R. Broom B.M. Hegde A.M. Ju Z. Kanchi R.S. Korkut A. Li J. Liang H. Ling S. Liu W. Lu Y. Mills G.B. Ng K-S. Rao A. Ryan M. Wang J. Weinstein J.N. Zhang J. Abeshouse A. Armenia J. Chakravarty D. Chatila W.K. de Bruijn I. Gao J. Gross B.E. Heins Z.J. Kundra R. La K. Ladanyi M. Luna A. Nissan M.G. Ochoa A. Phillips S.M. Reznik E. Sanchez-Vega F. Sander C. Schultz N. Sheridan R. Sumer S.O. Sun Y. Taylor B.S. Wang J. Zhang H. Anur P. Peto M. Spellman P. Benz C. Stuart J.M. Wong C.K. Yau C. Hayes D.N. Parker J.S. Wilkerson M.D. Ally A. Balasundaram M. Bowlby R. Brooks D. Carlsen R. Chuah E. Dhalla N. Holt R. Jones S.J.M. Kasaian K. Lee D. Ma Y. Marra M.A. Mayo M. Moore R.A. Mungall A.J. Mungall K. Robertson A.G. Sadeghi S. Schein J.E. Sipahimalani P. Tam A. Thiessen N. Tse K. Wong T. Berger A.C. Beroukhim R. Cherniack A.D. Cibulskis C. Gabriel S.B. Gao G.F. Ha G. Meyerson M. Schumacher S.E. Shih J. Kucherlapati M.H. Kucherlapati R.S. Baylin S. Cope L. Danilova L. Bootwalla M.S. Lai P.H. Maglinte D.T. Van Den Berg D.J. Weisenberger D.J. Auman J.T. Balu S. Bodenheimer T. Fan C. Hoadley K.A. Hoyle A.P. Jefferys S.R. Jones C.D. Meng S. Mieczkowski P.A. Mose L.E. Perou A.H. Perou C.M. Roach J. Shi Y. Simons J.V. Skelly T. Soloway M.G. Tan D. Veluvolu U. Fan H. Hinoue T. Laird P.W. Shen H. Zhou W. Bellair M. Chang K. Covington K. Creighton C.J. Dinh H. Doddapaneni H.V. Donehower L.A. Drummond J. Gibbs R.A. Glenn R. Hale W. Han Y. Hu J. Korchina V. Lee S. Lewis L. Li W. Liu X. Morgan M. Morton D. Muzny D. Santibanez J. Sheth M. Shinbro E. Wang L. Wang M. Wheeler D.A. Xi L. Zhao F. Hess J. Appelbaum E.L. Bailey M. Cordes M.G. Ding L. Fronick C.C. Fulton L.A. Fulton R.S. Kandoth C. Mardis E.R. McLellan M.D. Miller C.A. Schmidt H.K. Wilson R.K. Crain D. Curley E. Gardner J. Lau K. Mallery D. Morris S. Paulauskis J. Penny R. Shelton C. Shelton T. Sherman M. Thompson E. Yena P. Bowen J. Gastier-Foster J.M. Gerken M. Leraas K.M. Lichtenberg T.M. Ramirez N.C. Wise L. Zmuda E. Corcoran N. Costello T. Hovens C. Carvalho A.L. de Carvalho A.C. Fregnani J.H. Longatto-Filho A. Reis R.M. Scapulatempo-Neto C. Silveira H.C.S. Vidal D.O. Burnette A. Eschbacher J. Hermes B. Noss A. Singh R. Anderson M.L. Castro P.D. Ittmann M. Huntsman D. Kohl B. Le X. Thorp R. Andry C. Duffy E.R. Lyadov V. Paklina O. Setdikova G. Shabunin A. Tavobilov M. McPherson C. Warnick R. Berkowitz R. Cramer D. Feltmate C. Horowitz N. Kibel A. Muto M. Raut C.P. Malykh A. Barnholtz-Sloan J.S. Barrett W. Devine K. Fulop J. Ostrom Q.T. Shimmel K. Wolinsky Y. Sloan A.E. De Rose A. Giuliante F. Goodman M. Karlan B.Y. Hagedorn C.H. Eckman J. Harr J. Myers J. Tucker K. Zach L.A. Deyarmin B. Hu H. Kvecher L. Larson C. Mural R.J. Somiari S. Vicha A. Zelinka T. Bennett J. Iacocca M. Rabeno B. Swanson P. Latour M. Lacombe L. Têtu B. Bergeron A. McGraw M. Staugaitis S.M. Chabot J. Hibshoosh H. Sepulveda A. Su T. Wang T. Potapova O. Voronina O. Desjardins L. Mariani O. Roman-Roman S. Sastre X. Stern M-H. Cheng F. Signoretti S. Berchuck A. Bigner D. Lipp E. Marks J. McCall S. McLendon R. Secord A. Sharp A. Behera M. Brat D.J. Chen A. Delman K. Force S. Khuri F. Magliocca K. Maithel S. Olson J.J. Owonikoko T. Pickens A. Ramalingam S. Shin D.M. Sica G. Van Meir E.G. Zhang H. Eijckenboom W. Gillis A. Korpershoek E. Looijenga L. Oosterhuis W. Stoop H. van Kessel K.E. Zwarthoff E.C. Calatozzolo C. Cuppini L. Cuzzubbo S. DiMeco F. Finocchiaro G. Mattei L. Perin A. Pollo B. Chen C. Houck J. Lohavanichbutr P. Hartmann A. Stoehr C. Stoehr R. Taubert H. Wach S. Wullich B. Kycler W. Murawa D. Wiznerowicz M. Chung K. Edenfield W.J. Martin J. Baudin E. Bubley G. Bueno R. De Rienzo A. Richards W.G. Kalkanis S. Mikkelsen T. Noushmehr H. Scarpace L. Girard N. Aymerich M. Campo E. Giné E. Guillermo A.L. Van Bang N. Hanh P.T. Phu B.D. Tang Y. Colman H. Evason K. Dottino P.R. Martignetti J.A. Gabra H. Juhl H. Akeredolu T. Stepa S. Hoon D. Ahn K. Kang K.J. Beuschlein F. Breggia A. Birrer M. Bell D. Borad M. Bryce A.H. Castle E. Chandan V. Cheville J. Copland J.A. Farnell M. Flotte T. Giama N. Ho T. Kendrick M. Kocher J-P. Kopp K. Moser C. Nagorney D. O’Brien D. O’Neill B.P. Patel T. Petersen G. Que F. Rivera M. Roberts L. Smallridge R. Smyrk T. Stanton M. Thompson R.H. Torbenson M. Yang J.D. Zhang L. Brimo F. Ajani J.A. Angulo Gonzalez A.M. Behrens C. Bondaruk J. Broaddus R. Czerniak B. Esmaeli B. Fujimoto J. Gershenwald J. Guo C. Lazar A.J. Logothetis C. Meric-Bernstam F. Moran C. Ramondetta L. Rice D. Sood A. Tamboli P. Thompson T. Troncoso P. Tsao A. Wistuba I. Carter C. Haydu L. Hersey P. Jakrot V. Kakavand H. Kefford R. Lee K. Long G. Mann G. Quinn M. Saw R. Scolyer R. Shannon K. Spillane A. Stretch J. Synott M. Thompson J. Wilmott J. Al-Ahmadie H. Chan T.A. Ghossein R. Gopalan A. Levine D.A. Reuter V. Singer S. Singh B. Tien N.V. Broudy T. Mirsaidi C. Nair P. Drwiega P. Miller J. Smith J. Zaren H. Park J-W. Hung N.P. Kebebew E. Linehan W.M. Metwalli A.R. Pacak K. Pinto P.A. Schiffman M. Schmidt L.S. Vocke C.D. Wentzensen N. Worrell R. Yang H. Moncrieff M. Goparaju C. Melamed J. Pass H. Botnariuc N. Caraman I. Cernat M. Chemencedji I. Clipca A. Doruc S. Gorincioi G. Mura S. Pirtac M. Stancul I. Tcaciuc D. Albert M. Alexopoulou I. Arnaout A. Bartlett J. Engel J. Gilbert S. Parfitt J. Sekhon H. Thomas G. Rassl D.M. Rintoul R.C. Bifulco C. Tamakawa R. Urba W. Hayward N. Timmers H. Antenucci A. Facciolo F. Grazi G. Marino M. Merola R. de Krijger R. Gimenez-Roqueplo A-P. Piché A. Chevalier S. McKercher G. Birsoy K. Barnett G. Brewer C. Farver C. Naska T. Pennell N.A. Raymond D. Schilero C. Smolenski K. Williams F. Morrison C. Borgia J.A. Liptay M.J. Pool M. Seder C.W. Junker K. Omberg L. Dinkin M. Manikhas G. Alvaro D. Bragazzi M.C. Cardinale V. Carpino G. Gaudio E. Chesla D. Cottingham S. Dubina M. Moiseenko F. Dhanasekaran R. Becker K-F. Janssen K-P. Slotta-Huspenina J. Abdel-Rahman M.H. Aziz D. Bell S. Cebulla C.M. Davis A. Duell R. Elder J.B. Hilty J. Kumar B. Lang J. Lehman N.L. Mandt R. Nguyen P. Pilarski R. Rai K. Schoenfield L. Senecal K. Wakely P. Hansen P. Lechan R. Powers J. Tischler A. Grizzle W.E. Sexton K.C. Kastl A. Henderson J. Porten S. Waldmann J. Fassnacht M. Asa S.L. Schadendorf D. Couce M. Graefen M. Huland H. Sauter G. Schlomm T. Simon R. Tennstedt P. Olabode O. Nelson M. Bathe O. Carroll P.R. Chan J.M. Disaia P. Glenn P. Kelley R.K. Landen C.N. Phillips J. Prados M. Simko J. Smith-McCune K. VandenBerg S. Roggin K. Fehrenbach A. Kendler A. Sifri S. Steele R. Jimeno A. Carey F. Forgie I. Mannelli M. Carney M. Hernandez B. Campos B. Herold-Mende C. Jungk C. Unterberg A. von Deimling A. Bossler A. Galbraith J. Jacobus L. Knudson M. Knutson T. Ma D. Milhem M. Sigmund R. Godwin A.K. Madan R. Rosenthal H.G. Adebamowo C. Adebamowo S.N. Boussioutas A. Beer D. Giordano T. Mes-Masson A-M. Saad F. Bocklage T. Landrum L. Mannel R. Moore K. Moxley K. Postier R. Walker J. Zuna R. Feldman M. Valdivieso F. Dhir R. Luketich J. Mora Pinero E.M. Quintero-Aguilo M. Carlotti C.G. Jr Dos Santos J.S. Kemp R. Sankarankuty A. Tirapelli D. Catto J. Agnew K. Swisher E. Creaney J. Robinson B. Shelley C.S. Godwin E.M. Kendall S. Shipman C. Bradford C. Carey T. Haddad A. Moyer J. Peterson L. Prince M. Rozek L. Wolf G. Bowman R. Fong K.M. Yang I. Korst R. Rathmell W.K. Fantacone-Campbell J.L. Hooke J.A. Kovatich A.J. Shriver C.D. DiPersio J. Drake B. Govindan R. Heath S. Ley T. Van Tine B. Westervelt P. Rubin M.A. Lee J.I. Aredes N.D. Mariamidze A. An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell 2018 173 2 400 416.e11 10.1016/j.cell.2018.02.052 29625055
    [Google Scholar]
  20. Agarwal V. Bell G.W. Nam J.W. Bartel D.P. Predicting effective microRNA target sites in mammalian mRNAs. eLife 2015 4 e05005 10.7554/eLife.05005 26267216
    [Google Scholar]
  21. Chiang H.R. Schoenfeld L.W. Ruby J.G. Auyeung V.C. Spies N. Baek D. Johnston W.K. Russ C. Luo S. Babiarz J.E. Blelloch R. Schroth G.P. Nusbaum C. Bartel D.P. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 2010 24 10 992 1009 10.1101/gad.1884710 20413612
    [Google Scholar]
  22. Liu W. Wang X. Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data. Genome Biol. 2019 20 1 18 10.1186/s13059‑019‑1629‑z 30670076
    [Google Scholar]
  23. Krek A. Grün D. Poy M.N. Wolf R. Rosenberg L. Epstein E.J. MacMenamin P. da Piedade I. Gunsalus K.C. Stoffel M. Rajewsky N. Combinatorial microRNA target predictions. Nat. Genet. 2005 37 5 495 500 10.1038/ng1536 15806104
    [Google Scholar]
  24. Yu G. Wang L.G. Han Y. He Q.Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 2012 16 5 284 287 10.1089/omi.2011.0118 22455463
    [Google Scholar]
  25. Li M. Wang X. Liu J. Mao X. Li D. Wang Z. Tang Y. Wu S. Identification of Core Prognosis-Related Candidate Genes in Chinese Gastric Cancer Population Based on Integrated Bioinformatics. BioMed Res. Int. 2020 2020 1 14 10.1155/2020/8859826 33381592
    [Google Scholar]
  26. Lyu G. Li D. Xiong H. Xiao L. Tong J. Ning C. Wang P. Li S. Quantitative Proteomic Analyses Identify STO/BBX24 -Related Proteins Induced by UV-B. Int. J. Mol. Sci. 2020 21 7 2496 10.3390/ijms21072496 32260266
    [Google Scholar]
  27. Yang Y. Gu X. Li Z. Zheng C. Wang Z. Zhou M. Chen Z. Li M. Li D. Xiang J. Whole-exome sequencing of rectal cancer identifies locally recurrent mutations in the Wnt pathway. Aging (Albany NY) 2021 13 19 23262 23283 10.18632/aging.203618 34642262
    [Google Scholar]
  28. Lyu G. Li D. Li S. Hu H. STO and GA negatively regulate UV-B-induced Arabidopsis root growth inhibition. Plant Signal. Behav. 2019 14 12 1675471 10.1080/15592324.2019.1675471 31595819
    [Google Scholar]
  29. Li D.B. Lyu G. Jiang Y. Niu H. Wang X. Yin J. A RADISH (RAPHANUS SATIVUS L.) E3 UBIQUITIN LIGASE GENE RHA2b ENHANCES SEED DORMANCY AND TOLERANCE TO PREHARVEST SPROUTING IN TRANSGENIC WHEAT (TRITICUM AESTIVUM L.). Appl. Ecol. Environ. Res. 2019 17 6 13273 13288 10.15666/aeer/1706_1327313288
    [Google Scholar]
  30. Li D.B. Lyu G. Jiang Y. Niu H. Wang X. Yin J. Effects of exogenous RsRHA2b gene on key enzyme activities and expression of related genes in grain the filling stage of wheat (Triticum aestivum L.). Appl. Ecol. Environ. Res. 2019 17 6 15073 15086 10.15666/aeer/1706_1507315086
    [Google Scholar]
  31. Lu X. Li G. Liu S. Wang H. Chen B. MiR-585-3p suppresses tumor proliferation and migration by directly targeting CAPN9 in high grade serous ovarian cancer. J. Ovarian Res. 2021 14 1 90 10.1186/s13048‑021‑00841‑w 34238324
    [Google Scholar]
  32. Huang H. Xu Q. Zhang Y. Zhou Y. Ma K. Luo Y. miR-628-5p is a Potential Novel Prognosis Biomarker, Associated with Immune Infiltration in Bladder Urothelial Carcinoma. Curr. Pharm. Des. 2023 29 31 2477 2488 10.2174/0113816128254621231017062923 37916623
    [Google Scholar]
  33. Wei H. Wang J. Xu Z. Lu Y. Wu X. Zhuo C. Tan C. Tang Q. Pu J. miR‐584‐5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2. Mol. Genet. Genomic Med. 2019 7 6 e702 10.1002/mgg3.702 31044566
    [Google Scholar]
  34. Kida Y Kozono S Sudo H Kondou S Kawauchi J Ochiya T Kit, device, and method for detecting lung cancer. U.S. Patent 20230193402 2023
  35. Bédard ELR Roa W Method for detecting lung cancer using microrna expression and metabolomics. U.S. Patent 20230287514 2023
  36. Pavel A.B. Campbell J.D. Lenburg M.E. Spira A.E. Methods relating to lung cancer. U.S. Patent 20230255998 2023
  37. Zou R. Su D. Cheng H. Ying L. Zhou L. A peripheral blood mirna marker for diagnosis of non-small cell lung cancer. U.S. Patent 20230287504 2023
    [Google Scholar]
  38. Sudo H. Nobumasa H. Kozono S. Kondou S. Kawauchi J. Ochiai A. Lung cancer detection kit or device, and detection method. U.S. Patent 20240183875 2024
    [Google Scholar]
  39. Liu C. Qin Q. Cong H. Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight 2022 1 1 8 10.58567/ci01010004
    [Google Scholar]
  40. Smolle E. Leko P. Stacher-Priehse E. Brcic L. El-Heliebi A. Hofmann L. Quehenberger F. Hrzenjak A. Popper H.H. Olschewski H. Leithner K. Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer. Mol. Oncol. 2020 14 11 2853 2867 10.1002/1878‑0261.12780 32777161
    [Google Scholar]
  41. Li C.H. Chan M.H. Chang Y.C. The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis. Aging 2022 14 7 3233 3258 10.18632/aging.204010 35404841
    [Google Scholar]
  42. Chang W. Li H. Wu C. Zhong L. Zhu T. Chang Z. Ou W. Wang S. Identification of an amino acid metabolism-related gene signature for predicting prognosis in lung adenocarcinoma. Genes 2022 13 12 2295 10.3390/genes13122295 36553562
    [Google Scholar]
  43. Xiao W. Geng W. Zhou M. Xu J. Wang S. Huang Q. Sun Y. Li Y. Yang G. Jin Y. POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulating HIF1A signaling pathway. Cell Death Dis. 2022 13 5 427 10.1038/s41419‑022‑04857‑y 35504868
    [Google Scholar]
  44. He L. Endress J. Cho S. Li Z. Zheng Y. Asara J.M. Blenis J. Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. Sci. Adv. 2022 8 20 eabm8786 10.1126/sciadv.abm8786 35594343
    [Google Scholar]
  45. Li H.J. Ke F.Y. Lin C.C. Lu M.Y. Kuo Y.H. Wang Y.P. Liang K.H. Lin S.C. Chang Y.H. Chen H.Y. Yang P.C. Wu H.C. ENO1 promotes lung cancer metastasis via HGFR and WNT signaling–driven epithelial-to-mesenchymal transition. Cancer Res. 2021 81 15 4094 4109 10.1158/0008‑5472.CAN‑20‑3543 34145039
    [Google Scholar]
  46. Sun L. Suo C. Zhang T. Shen S. Gu X. Qiu S. Zhang P. Wei H. Ma W. Yan R. Chen R. Jia W. Cao J. Zhang H. Gao P. ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism. Nat. Chem. Biol. 2023 19 12 1492 1503 10.1038/s41589‑023‑01391‑6 37500770
    [Google Scholar]
  47. Chen F.T. Zhong F.K. Kinesin Family Member 18A (KIF18A) contributes to the proliferation, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Dis. Markers 2019 2019 1 9 10.1155/2019/6383685 31772692
    [Google Scholar]
  48. Yong J. Huang L. Chen G. Luo X. Chen H. Wang L. High expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer. Bioengineered 2021 12 1 3426 3433 10.1080/21655979.2021.1943109 34227915
    [Google Scholar]
/content/journals/pra/10.2174/0115748928344326240927071620
Loading
Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma
Bentham Science Publishers ; https://doi.org/10.2174/0115748928344326240927071620
/content/journals/pra/10.2174/0115748928344326240927071620
/content/journals/pra/10.2174/0115748928344326240927071620
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher's website along with the published article.

file format download Download

  • Article Type:     Research Article
Keywords: therapeutic target ; prognosis ; microRNA-1468-5p ; lung adenocarcinoma ; biomarker ; HIF-1 signaling pathway

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test