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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of “Difficult Sequences”
- Source: Protein and Peptide Letters, Volume 19, Issue 11, Nov 2012, p. 1231 - 1236
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- 01 Nov 2012
Abstract
A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.
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