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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139
- Source: Protein and Peptide Letters, Volume 19, Issue 8, Aug 2012, p. 832 - 838
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- 01 Aug 2012
Abstract
We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139. Structure quality measures indicate substantial improvement, with residues in the most favored regions of the Ramachandran plot increasing by 14 % and with WHAT IF statistics (Vriend, G. J. Mol. Graph., 1990, 8(1), 52-56) falling closer to expected values for well-refined structures.
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