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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU
- Source: Protein and Peptide Letters, Volume 19, Issue 4, Feb 2012, p. 406 - 410
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- 01 Feb 2012
Abstract
O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ‘ click peptide’ protocol employed for assembling ‘ difficult sequence’ peptides.
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