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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans
- Source: Protein and Peptide Letters, Volume 17, Issue 8, Aug 2010, p. 1053 - 1057
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- 01 Aug 2010
Abstract
D-Alanine:D-Alanine ligase (DDl) catalyzes the formation of D-Alanine:D-Alanine dipeptide and is an essential enzyme in bacterial cell wall biosynthesis. This enzyme does not have a human ortholog, making it an attractive target for developing new antibiotic drugs. We determined the crystal structure at 2.23 Å resolution of DDl from Streptococcus mutans (SmDDl), the principal aetiological agent of human dental caries. This structure reveals that SmDDl is a dimer and has a disordered ω-loop region.
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