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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Design, Synthesis and Preliminary Activity Evaluation of Novel L-Lysine Derivatives as Aminopeptidase N/CD13 Inhibitors
- Source: Protein and Peptide Letters, Volume 17, Issue 7, Jul 2010, p. 847 - 853
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- 01 Jul 2010
Abstract
A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC50 = 9.6 ± 1.3 μM) and C20 (IC50 = 13.6 ± 1.9 μM) were equivalent to the positive control Bestatin (IC50 = 11.3 ± 1.6 μM).
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