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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein
- Source: Protein and Peptide Letters, Volume 16, Issue 12, Dec 2009, p. 1442 - 1446
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- 01 Dec 2009
Abstract
Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities.
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