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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Confocal Microscopy Evidence of Prion Protein Fragment hPrP[173-195] Internalization in Rat B104 Neuroblastoma Cell Line
- Source: Protein and Peptide Letters, Volume 16, Issue 11, Nov 2009, p. 1281 - 1290
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- 01 Nov 2009
Abstract
The cytotoxicity of hPrP[173-195] prion peptide against a neuroblastoma cell model was found independent of its tendency to aggregate over time. Cytosolic and nuclear inclusions of peptide were highlighted by confocal microscopy, suggesting a role as a transcription factor in activating signal transduction pathways involved in cell toxicity.
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