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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Human Prion Protein Helices: Studying Their Stability by Molecular Dynamics Simulations (SUPPLEMENTARY MATERIAL)
- Source: Protein and Peptide Letters, Volume 16, Issue 9, Sep 2009, p. 1057 - 1062
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- 01 Sep 2009
Abstract
To study the intrinsic structural properties of three human prion helices and analyse their stability, we conducted molecular dynamics simulations, applied helix propensity predictions and evaluated the energetic contribution of the helical regions to the PrP protein stability. Our results suggest that three helices present different stability and the helix 2 results the least stable.
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