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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Calcium-Independent Membrane Damage by Venom Phospholipases A2
- Source: Protein and Peptide Letters, Volume 16, Issue 8, Aug 2009, p. 877 - 886
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- 01 Aug 2009
Abstract
Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
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