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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands
- Source: Protein and Peptide Letters, Volume 16, Issue 7, Jul 2009, p. 805 - 809
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- 01 Jul 2009
Abstract
A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.
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