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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Protein Engineering of a Fibroblast Growth Factor 2 Protein for Targeting to Bone Mineral Hydroxyapatite
- Source: Protein and Peptide Letters, Volume 16, Issue 6, Jun 2009, p. 664 - 667
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- 01 Jun 2009
Abstract
The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.
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