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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Design and Synthesis of Substrates for Model Ribosomal Reactions
- Source: Protein and Peptide Letters, Volume 16, Issue 4, Apr 2009, p. 392 - 401
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- 01 Apr 2009
Abstract
2'/3'-O-[Bz(NO2)-Orn(Boc)]-5'-O-Piv-Ado (1) and its deoxy analog: 3'-O-[Bz(NO2)-Orn(Boc)]-5'-O-Piv-2'- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2'-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.
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