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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors
- Source: Protein and Peptide Letters, Volume 16, Issue 3, Mar 2009, p. 285 - 288
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- 01 Mar 2009
Abstract
NPTX-594 is a neurotoxic acylpolyamine isolated from a Madagascar Joro spider and acts as a specific blocker of glutamate receptors (GluRs). The present study reports the creation of novel NPTX-594 analogs with thiol-containing fluorophores for use as visualization probes for the analysis of the binding mode between spider toxins and GluRs, together with the result of their cricket bioassay.
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