Conservation of Average Hydrophobicity of Apolar Aminoacids in Polypeptides Constituting Same Glycosyl Hydrolase Sub-Family Enzymes

Polypeptides constituting the same functional enzyme in cells of different origins have small sequence similarities among themselves. Amino acid analysis reveals that each glycosyl hydrolase sub-family polypeptides conserves an average hydrophobicity value for total constituent apolar amino acids. The value may be a measure of the driving force present in the polypeptide for designed primary collapse for three-dimensional active site formation.