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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Unraveling Sub-Site Specificities of Peptidic Serine Protease Inhibitors by Substitutional and Structural Analysis
- Source: Protein and Peptide Letters, Volume 12, Issue 5, Jul 2005, p. 449 - 456
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- 01 Jul 2005
Abstract
The interaction of peptidic inhibitors with serine proteases is investigated using peptide spot synthesis on cellulose sheets. This method permits a highly parallel analysis of subsite specificities and an optimization of peptidic inhibitors towards higher affinity and specificity for a given target protease. Information from crystal structures of corresponding protease/inhibitor complexes may help to explain the observed binding pattern.
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