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2000
Volume 12, Issue 5
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

The interaction of peptidic inhibitors with serine proteases is investigated using peptide spot synthesis on cellulose sheets. This method permits a highly parallel analysis of subsite specificities and an optimization of peptidic inhibitors towards higher affinity and specificity for a given target protease. Information from crystal structures of corresponding protease/inhibitor complexes may help to explain the observed binding pattern.

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/content/journals/ppl/10.2174/0929866054395374
2005-07-01
2025-10-21
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