[TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings

Qian-Yu Zhao; Qiang Chen; Yun Feng; Xin Lin; Rui Wang

doi:10.2174/0929866053765743

ISSN: 0929-8665
E-ISSN: 1875-5305

[TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings
Authors: Qian-Yu Zhao¹, Qiang Chen², Yun Feng³, Xin Lin⁴ and Rui Wang⁵
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¹ Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, Peoples Republic of China. ² Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, Peoples Republic of China. ³ Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, Peoples Republic of China. ⁴ Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, Peoples Republic of China. ⁵ Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, Peoples Republic of China.
Source: Protein and Peptide Letters, Volume 12, Issue 4, May 2005, p. 323 - 326
DOI: https://doi.org/10.2174/0929866053765743
- Available online: 01 May 2005

Abstract

[Tic4]EM1 and [Tic4]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic4]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor.

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2005-05-01

2025-10-15

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Article Type: Review Article

Keyword(s): endomorphins; opioid; rat aorta rings; tic; vasorelaxant response

[TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings

Abstract

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