Crystallization and Preliminary X-Ray Crystallographic Study of the Viral Zα Domain Bound to Left-Handed Z-DNA

The Zα domain (yabaZαE3L) of the E3L protein homologue from Yaba-like disease virus, a yatavirus, was cocrystallized with d(TCGCGCG)2 in the Z-conformation. The crystals belong to the P21212 space group, with unit-cell parameters a=51.20 Å, b=92.45 Å, c=48.02 Å, α=β= γ=90 . The diffraction data were collected up to a resolution of 2.2 Å. The structure of viral Za motif will provide an insight into how diverse Zα motifs recognize Z-DNA.