Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity

Maria Sakarellos-Daitsiotis; Manh-Thong Cung; Constantinos Sakarellos; Zouhair E. Hilali; Aggeliki Kosmopoulou; Chryssa Voitharou

doi:10.2174/0929866043407020

ISSN: 0929-8665
E-ISSN: 1875-5305

Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity
Authors: Maria Sakarellos-Daitsiotis¹, Manh-Thong Cung², Constantinos Sakarellos³, Zouhair E. Hilali⁴, Aggeliki Kosmopoulou⁵ and Chryssa Voitharou⁶
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¹ Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece ² Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece ³ Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece ⁴ Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece ⁵ Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece ⁶ Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
Source: Protein and Peptide Letters, Volume 11, Issue 4, Aug 2004, p. 367 - 375
DOI: https://doi.org/10.2174/0929866043407020
- Available online: 01 Aug 2004

Abstract

Application of complementary B and T cell epitopes in inducing anti-idiotypic and anticlonotypic antibodies capable of regulating or suppressing the autoimmune responses in experimental autoimmune myasthenia gravis (EAMG), allergic neuritis (EAN) and allergic encephalomyelitis (EAE) has been the stimulus of many research efforts. Studies on the idiotypic / anti-idiotypic network of anti-La / SSB positive sera from patients with Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) and on animals immunized with the complementary epitopes are presented.

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2004-08-01

2025-10-08

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Article Type: Review Article

Keyword(s): anti-idiotypic antibodies; autoimmune diseases; complementary epitopes

Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity

Abstract

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