Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules

Damiano Banfi; Manfred Mutter; Luc Patiny

doi:10.2174/0929866043406274

ISSN: 0929-8665
E-ISSN: 1875-5305

Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules
Authors: Damiano Banfi¹, Manfred Mutter² and Luc Patiny³
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¹ Institute of Chemical Sciences and Engineering (ISIC) Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland. ² Institute of Chemical Sciences and Engineering (ISIC) Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland. ³ Institute of Chemical Sciences and Engineering (ISIC) Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Source: Protein and Peptide Letters, Volume 11, Issue 6, Dec 2004, p. 539 - 542
DOI: https://doi.org/10.2174/0929866043406274
- Available online: 01 Dec 2004

Abstract

This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Bochydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis.

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2004-12-01

2025-09-03

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Article Type: Review Article

Keyword(s): amino acids; chemoselective ligation; electrophilic amino group; n-boc-3-(4-cyanophenyl)oxaziridine (bpco); synthesis; template assembled synthetic proteins (tasp)

Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules

Abstract

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