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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Production of Recombinant Human Calcitonin from Silkworm (B. Mori) Larvae infected by Baculovirus
- Source: Protein and Peptide Letters, Volume 9, Issue 4, Aug 2002, p. 323 - 329
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- 01 Aug 2002
Abstract
A synthetic modified gene encoding the human calcitonin analog (hmCT) was expressed by use of the baculovirus expression system. After injection with recombinant baculoviruses, the hmCT-GST fusion protein was produced within the silkworm larvae. The fusion protein was purified by affinity chromatography. Biological activity of hmCT for hypercalcemic effect was determined in normal rats.
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