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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Crystallization and Preliminary X-Ray Diffraction Analysis of FKBP12 Complexed with a Novel Neurotrophic Ligand
- Source: Protein and Peptide Letters, Volume 9, Issue 5, Oct 2002, p. 459 - 463
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- 01 Oct 2002
Abstract
A novel neurotrophic ligand, (3R)-4-(p-Toluenesulfonyl)-1,4-thiazane-3-carboxylic acid-L-Leucine ethyl ester, has been complexed with FKBP12 and crystallized using the hanging-drop vapor-diffusion method. Crystals belong to P2 1 space group, with unit cell parameters a=41.2, b=29.6, c=41.5Å, β=114.0 . The crystals diffract to 1.8 Å resolution limit.
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