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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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The use of Dodt as a Non-Malodorous Scavenger in Fmoc-Based Peptide Synthesis
- Source: Protein and Peptide Letters, Volume 9, Issue 5, Oct 2002, p. 379 - 385
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- 01 Oct 2002
Abstract
We have synthesized a random group of peptides and performed cleavages using various cleavage cocktails including 3,6-dioxa-1,8-octanedithiol (DODT). Purity of the peptides was compared to that obtained with standard protocols for cleavage using RP-HPLC and Maldi-Tof mass spectrometry. We show that stinking thiols can be replaced by the almost odourless (DODT) without negatively affecting the purity of the end product.
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