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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Effect of Phospholipid Membrane on Conformation of Retro-Sequence Amyloid- beeta-Peptide 35-25 and Normal Amyloid-beeta-Peptide 25-35
- Source: Protein and Peptide Letters, Volume 8, Issue 5, Oct 2001, p. 395 - 398
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- 01 Oct 2001
Abstract
Negatively-charged phospholipid membrane does not affect the random coil conformation of a non-neurotoxic amyloid-beeta-peptide having a retro-sequence 35-25 (Abeta 35-25), whereas it changes the conformation of a neurotoxic normal-sequence peptide A beeta 25-35 from a random coil to a beeta-sheet-like structure under the same condition. The formation of the ordered structure seems to be closely related to the expression of neurotoxicity.
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