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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Syntheses Of Neurotensin (Nt) Analogues And Their Comparative Anorectic Effect On Food Intake In Rats
- Source: Protein and Peptide Letters, Volume 8, Issue 6, Dec 2001, p. 461 - 468
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- 01 Dec 2001
Abstract
Five analogues of neurotensin(NT:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) were prepared by the solid-phase method and their comparative anorectic effects on food intake in rats were examined. Among them, [Phe(NO2)3,11]-NT and [Phe(4F)3,11]-NT showed stronger anorectic activity than that of the parent peptide but [Tyr(Me)3,11]-NT was less active than the parent peptide. On the contrary, the other two analogues, [Sar7,10]-NT and [beta Ala7,10]-NT had no anorectic activity.
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