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image of Harzianolides H-J: Three New Butenolides Isolated from the Fungus Trichoderma harzianum

Abstract

Background

Marine fungi have been recognized as new sources for the discovery of valuable secondary metabolites, providing lead compounds for drug discovery and development.

Objective

The objective of this study was to isolate and identify the secondary metabolites from the marine-derived fungus ZN-4 and evaluate their antifungal activity.

Method

Fungus strain ZN-4 was initially fermentated using a PDB liquid medium. Subsequently, extensive chromatographic methods were applied to isolate the fermentation cultures of ZN-4, and the chemical structures of isolate compounds were elucidated by 1D and 2D NMR, ECD, and HRESIMS. The antifungal activity was evaluated using the broth microdilution method.

Result

Three new butenolides, harzianolides H–J (–), were isolated from T. harzianum ZN-4, and cultivated on a sterilized PDB medium. Activity evaluation showed that compounds − exhibited potent antifungal activity with MIC values of 12.5−100 g/mL against the phytopathogenic fungus .

Conclusion

This study not only enriched the structural diversity of the harzianolide family but also revealed their anti- activity, which may be potential antifungal agents.

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2024-12-16
2025-11-04

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Harzianolides H-J: Three New Butenolides Isolated from the Fungus Trichoderma harzianum
Bentham Science Publishers ; https://doi.org/10.2174/0122103155358814241211113647
/content/journals/npj/10.2174/0122103155358814241211113647
/content/journals/npj/10.2174/0122103155358814241211113647
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  • Article Type:     Research Article
Keywords: butenolides ; antifungal activity ; secondary metabolites ; Trichoderma harzianum

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