Neuroscience and Biomedical Engineering (Discontinued) - Volume 2, Issue 3, 2014

Subjective cognitive decline (SCD) is common in older people. It is an upsetting symptom in which seemingly healthy individuals report self-perceived decline in cognition function, usually memory, without objective evidence on formal neuropsychological tests. There is rapidly growing evidence that SCD may be an early symptomatic sign of the first effects of Alzheimer's disease (AD) pathology on cognitive functioning b Read More

Deep brain stimulation (DBS) is an increasingly used surgical treatment for a range of neurological disorders, most commonly movement disorders. DBS provides durable electrical stimulation in different regions of the human brain according to a disorder specific manner. The mechanisms of action of DBS, particularly the interfaces between electrodes and brain are not well known and disputed. The interfaces have an impact Read More

In endovascular interventional surgery, the virtual-reality (VR) simulator is critical for robotic catheter operating system since it offers physicians visual information between catheter and vessel. In spite of most VR systems using mass-spring to formulate vascular physical model, the uniform deformation doesn’t satisfy the vascular characteristics. In order to simulate the vascular deformation more vividly, we introduce stand Read More

Working memory (WM) has been one of the central themes in the area of cognitive neuroscience research for the past decades. WM refers to the temporary storage of information and a memory system which can carry on the processing of information. Memory load plays an important role in WM, through varying numbers of stimulus to realize the change of memory load. Functional magnetic resonance imaging (fMRI) as a co Read More

Previous studies have reported that insomniacs tend to have a discrepancy between nocturnal sleep length reported in a self-checked sleep diary and actigraphically recorded sleep length. However, a predictive marker for the presence of this phenomenon remains unclear. In order to clarify this issue, we calculated subjective-objective difference (SOD), using diary estimates of sleep period time (SPT) minus actigraphically me Read More

Robot-aided rehabilitation training allows patients to receive a more effective and stable rehabilitation process. Exoskeleton devices are superior to the endpoint manipulators and cable suspension devices on the aspect that they can train and measure the angle and torque on each joint of impaired limbs. For robotic devices, physical safety should be guaranteed since the robot-assisted training relies on high human-robot in Read More

Transcranial direct current stimulation (tDCS) involves passing low currents through the brain and is a promising tool for inducing alteration of cortical excitability. However, tDCS presents challenges in terms of optimization of the electrode placement and stimulation parameters especially in cases of heterogeneously damaged cortical structures. The analysis of a simplified multi-shell computational head-model indicated th Read More

Effective diagnosis of Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI), a transitional state between normal and AD, is of great importance in dementia research. Different neuroimaging biomarkers for AD may be potentially different and complementary in the diagnosis of AD. It is necessary to combine multimodal neuroimaging biomarkers simultaneously for the higher classification accuracy and more effe Read More