Mini Reviews in Medicinal Chemistry - Volume 23, Issue 8, 2023
Volume 23, Issue 8, 2023
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A Glimpse at the Quinoline-Hybridization Approach for the Development of New Antimalarials
Authors: Sukhbir Kaur, Amanjot Kaur, Amandeep Arora and Vipan KumarOne of the most fatal infectious diseases, malaria, still poses a threat to about half of the world's population and is the leading cause of death worldwide. The use of artemisinin-based combination therapy has helped to significantly reduce the number of deaths caused by malaria, but the emergence of drug resistance threatens to undo this gain. In a bid to boost adherence, several new combination therapies with effectiv Read More
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Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships
Authors: Shaochen Li, Min Lv and Hui XuNatural products are an invaluable source for the discovery of drug and pesticide candidates. Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae. Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity, anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity, etc. In recent years, lots of works focused on the Read More
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Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application
Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in primates, which is predominantly synthesized in the adrenal cortex. A characteristic curve of growth and decline of its synthesis during life was observed, together with the corresponding formation of its sulphate ester (DHEAS). High levels of plasma circulating DHEA are suggested as a marker of human longevity, and various pathophysiological conditio Read More
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KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer
Authors: Abdullah Althaiban, Anita Thyagarajan and Ravi Prakash SahuPancreatic ductal adenocarcinoma (PDAC) is one of the highly aggressive malignancies and the leading cause of cancer-related deaths. Despite recent advancements, the overall therapeutic responses in PDAC patients remained relatively low or short-lived. While KRAS is the most frequently mutated proto-oncogene and represents a critical driver, it remains challenging to target all mutant variants. Thus, strategies to target t Read More
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A Recent Appraisal of Small-Organic Molecules as Anti-Alzheimer’s Agents
Authors: Mohan Gupta, Avinash Kumar, Madhwi Ojha, Shabana Kausar Khan and Sumitra NainBackground: Alzheimer’s disease (AD) is an irreversible, progressive and very complex brain disorder. There is still uncertainty about the etiology of AD; however, a few hallmarks like an aggregation of tau proteins, amyloid-β plaques, oxidative stress, low level of choline in the brain etc., play significant roles. Objective: In the present work, we aim to evaluate the recent progress in the development of small organic molecules Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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