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- ISSN: 1389-5575
- E-ISSN: 1875-5607
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α-Halogenoacrylic Derivatives of Antitumor Agents
- Source: Mini Reviews in Medicinal Chemistry, Volume 9, Issue 1, Jan 2009, p. 81 - 94
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- 01 Jan 2009
Abstract
In this review article we have reported a series of hybrid compounds characterized by the presence of a α- halogenocryloyl alkylating moiety of low chemical reactivity, linked to known antitumor agents or their active moieties. Among them, brostallicin (PNU-166196), was selected for clinical development and is now undergoing Phase II studies in patients with advanced or metastatic soft tissue sarcoma.
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